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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study
- Source: Letters in Drug Design & Discovery, Volume 3, Issue 3, Apr 2006, p. 149 - 151
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- 01 Apr 2006
Abstract
Two homologous trinuclear polyamine chelates with either Pt(II) (Ia) or Pd(II) (Ib) were screened for their anticancer properties. Their growth-inhibition activity towards a human tongue epithelioma (HSC-3) was assessed in vitro, and the effect of the cation alteration was determined (IC50 =32 μM for Ib vs 66 μM for Ia).
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