Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin

Ahmed Kamal; B. A. Kumar; M. Arifuddin; Sunanda G. Dastidar

doi:10.2174/157018006776286907

ISSN: 1570-1808
E-ISSN: 1875-628X

Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin
Authors: Ahmed Kamal¹, B. A. Kumar², M. Arifuddin³ and Sunanda G. Dastidar⁴
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¹ Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad - 500007, India. ² Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad - 500007, India. ³ Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad - 500007, India. ⁴ Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad - 500007, India.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 3, Apr 2006, p. 205 - 209
DOI: https://doi.org/10.2174/157018006776286907
- Available online: 01 Apr 2006

Abstract

Some new 4β-N-heteroaryl analogues of podophyllotoxin have been prepared by employing Red Phosphorous/I2 reagent system. These 4β-N-heteroaryl analogues have been evaluated for their cytotoxicity against six human cancer cell lines and some representative ones have shown promising anticancer activity.

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2006-04-01

2025-10-16

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Article Type: Research Article

Keyword(s): anticancer activity; benzothiazoles; Epipodophyllotoxin; pyrimidines

Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin

Abstract

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