Synthesis and Evaluation of Aminoglycosides as Inhibitors for Rev binding to Rev Responsive Element

Hayamitsu Adachi; Yoshinori Takahashi; Motoki Kyo; Tsuyoshi Sato; Yoshio Nishimura

doi:10.2174/157018006775789694

ISSN: 1570-1808
E-ISSN: 1875-628X

Synthesis and Evaluation of Aminoglycosides as Inhibitors for Rev binding to Rev Responsive Element
Authors: Hayamitsu Adachi¹, Yoshinori Takahashi², Motoki Kyo³, Tsuyoshi Sato⁴ and Yoshio Nishimura⁵
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¹ Microbial Chemistry Research Center, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan. ² Microbial Chemistry Research Center, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan. ³ Microbial Chemistry Research Center, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan. ⁴ Microbial Chemistry Research Center, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan. ⁵ Microbial Chemistry Research Center, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 2, Mar 2006, p. 71 - 75
DOI: https://doi.org/10.2174/157018006775789694
- Available online: 01 Mar 2006

Abstract

Interactions of α-amino or guanidino-α-hydroxybutyryl-aminoglycosides with an essential sequence of Rev responsive element (RRE) in HIV-1 mRNA were evaluated using surface plasmon resonance imaging. Aminoglycosides were proved to bind nonspecifically to RRE.

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2006-03-01

2025-09-22

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Article Type: Research Article

Keyword(s): Aminoglycoside; RNA recognition; surface plasmon resonance imaging

Synthesis and Evaluation of Aminoglycosides as Inhibitors for Rev binding to Rev Responsive Element

Abstract

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