Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors

E. M.F. Muri; H. Mishra; S. M. Stein; J. S. Williamson

doi:10.2174/1570180043485680

ISSN: 1570-1808
E-ISSN: 1875-628X

Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors
Authors: E. M.F. Muri¹, H. Mishra², S. M. Stein³ and J. S. Williamson⁴
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¹ Department of Medicinal Chemistry, University of Mississippi, University MS 38677, USA. ² Department of Medicinal Chemistry, University of Mississippi, University MS 38677, USA. ³ Department of Medicinal Chemistry, University of Mississippi, University MS 38677, USA. ⁴ Department of Medicinal Chemistry, University of Mississippi, University MS 38677, USA.
Source: Letters in Drug Design & Discovery, Volume 1, Issue 1, Jan 2004, p. 30 - 34
DOI: https://doi.org/10.2174/1570180043485680
- Available online: 01 Jan 2004

Abstract

A computer-generated homology model of the antimicrobial target Helicobacter pylori urease was derived, using the x-ray crystal structure of Klebsiella aerogenes as a template, in order to design novel urease inhibitors. Based on these computational studies, several heterocyclic hydroxamic acid derivatives have been designed, synthesized, and examined for their ability to inhibit urease activity.

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2004-01-01

2025-09-30

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Article Type: Review Article

Keyword(s): antimicrobial; helicobacter pylori; hydroxamic acids; urease

Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors

Abstract

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