Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity

M. Brinkman; J. Walter; I. Jennes; M. Neugebauer; W. Bertling; S. Grein; M. Thies; M. Weigand; T. Beyer; M. Herrmann

doi:10.2174/1570180043485545

ISSN: 1570-1808
E-ISSN: 1875-628X

Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity
Authors: M. Brinkman¹, J. Walter², I. Jennes³, M. Neugebauer⁴, W. Bertling⁵, S. Grein⁶, M. Thies⁷, M. Weigand⁸, T. Beyer⁹ and M. Herrmann¹⁰
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¹ responsif GmbH, Schallershofer Str. 84, D-91056 Erlangen, Germany. ² responsif GmbH, Schallershofer Str. 84, D-91056 Erlangen, Germany. ³ responsif GmbH, Schallershofer Str. 84, D-91056 Erlangen, Germany. ⁴ responsif GmbH, Schallershofer Str. 84, D-91056 Erlangen, Germany. ⁵ responsif GmbH, Schallershofer Str. 84, D-91056 Erlangen, Germany. ⁶ responsif GmbH, Schallershofer Str. 84, D-91056 Erlangen, Germany. ⁷ responsif GmbH, Schallershofer Str. 84, D-91056 Erlangen, Germany. ⁸ responsif GmbH, Schallershofer Str. 84, D-91056 Erlangen, Germany. ⁹ responsif GmbH, Schallershofer Str. 84, D-91056 Erlangen, Germany. ¹⁰ responsif GmbH, Schallershofer Str. 84, D-91056 Erlangen, Germany.
Source: Letters in Drug Design & Discovery, Volume 1, Issue 2, Apr 2004, p. 137 - 147
DOI: https://doi.org/10.2174/1570180043485545
- Available online: 01 Apr 2004

Abstract

Subcutaneous vaccination of mice with chimerical polyomavirus-likeparticles consisting of a VP1-ovalbumin (OVA252-270) fusion protein induced immunodominant H-2Kb-restricted and OVA257-264-specific CD8 T cells in mice. Single immunisations with VP1-OVA252-270 capsoids failed to have beneficial effects on tumour protection, only double vaccinations in weekly intervals protected mice from lethal MO5 melanoma challenge.

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2004-04-01

2025-09-27

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Article Type: Review Article

Keyword(s): cell-mediated immunity; peptide delivery; tumour vaccination; virus-like-particles

Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity

Abstract

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