Quaternary Heteroarenium Salts as the Competitive Inhibitors of the Brain Acetylcholinesterase

Kamil Kuca; Jiri Cabal; Jiri Patocka; Vlastimil Dohnal

doi:10.2174/1570180043485509

ISSN: 1570-1808
E-ISSN: 1875-628X

Quaternary Heteroarenium Salts as the Competitive Inhibitors of the Brain Acetylcholinesterase
Authors: Kamil Kuca¹, Jiri Cabal², Jiri Patocka³ and Vlastimil Dohnal⁴
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¹ Purkyne Medical Military Academy, Department of Toxicology, Trebesska 1575, Hradec Kralove, 500 01, Czech Republic. ² Purkyne Medical Military Academy, Department of Toxicology, Trebesska 1575, Hradec Kralove, 500 01, Czech Republic. ³ Purkyne Medical Military Academy, Department of Toxicology, Trebesska 1575, Hradec Kralove, 500 01, Czech Republic. ⁴ Purkyne Medical Military Academy, Department of Toxicology, Trebesska 1575, Hradec Kralove, 500 01, Czech Republic.
Source: Letters in Drug Design & Discovery, Volume 1, Issue 2, Apr 2004, p. 97 - 100
DOI: https://doi.org/10.2174/1570180043485509
- Available online: 01 Apr 2004

Abstract

The interaction of seventeen heteroarenium salts with the enzyme acetylcholinesterase was investigated using in vitro experiments. Rat brains were used as a source of the enzyme. All compounds involved in this study were found to be competitive acetylcholinesterase inhibitors. 10-methyl-acridinium iodide seems to be the most potent acetylcholinesterase inhibitor.

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2004-04-01

2025-09-27

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Article Type: Review Article

Keyword(s): acetylcholinesterase; heteroarenium salts; inhibition; reactivation

Quaternary Heteroarenium Salts as the Competitive Inhibitors of the Brain Acetylcholinesterase

Abstract

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