Apoptosis Signaling Pathways as Therapeutic Targets in Lung Injury

Kazuyoshi Kuwano; Naoki Hagimoto; Michihiro Yoshimi; Takashige Maeyama; Yoichi Nakanishi

doi:10.2174/1570180043398849

ISSN: 1570-1808
E-ISSN: 1875-628X

Apoptosis Signaling Pathways as Therapeutic Targets in Lung Injury
Authors: Kazuyoshi Kuwano¹, Naoki Hagimoto², Michihiro Yoshimi³, Takashige Maeyama⁴ and Yoichi Nakanishi⁵
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¹ Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan ² Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan ³ Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan ⁴ Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan ⁵ Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Source: Letters in Drug Design & Discovery, Volume 1, Issue 3, Jul 2004, p. 263 - 268
DOI: https://doi.org/10.2174/1570180043398849
- Available online: 01 Jul 2004

Abstract

Apoptosis plays a major role in homeostasis as well as proliferation and differentiation. The important role of epithelial and endothelial cell apoptosis in lung injury and repair has been demonstrated. Modulating signaling molecules of apoptosis may be effective treatment against lung injury.

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2004-07-01

2025-09-29

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Article Type: Review Article

Keyword(s): apoptosis; death receptor; fibrosis; lung injury; mitochondria; necrosis

Apoptosis Signaling Pathways as Therapeutic Targets in Lung Injury

Abstract

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