Design and Cytotoxicity Analysis of a Conjugate Containing the New DGalactose- Binding Lectin SELld and the Non-Toxic Type 2 Ribosome- Inactivating Protein Nigrin b

Jorge Benitez; M. A. Rojo; Raquel Munoz; J. Miguel Ferreras; Pilar Jimenez; Tomas Girbes

doi:10.2174/1570180043398687

ISSN: 1570-1808
E-ISSN: 1875-628X

Design and Cytotoxicity Analysis of a Conjugate Containing the New DGalactose- Binding Lectin SELld and the Non-Toxic Type 2 Ribosome- Inactivating Protein Nigrin b
Authors: Jorge Benitez¹, M. A. Rojo², Raquel Munoz³, J. Miguel Ferreras⁴, Pilar Jimenez⁵ and Tomas Girbes⁶
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¹ Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Valladolid, 47005, Valladolid, Spain. ² Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Valladolid, 47005, Valladolid, Spain. ³ Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Valladolid, 47005, Valladolid, Spain. ⁴ Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Valladolid, 47005, Valladolid, Spain. ⁵ Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Valladolid, 47005, Valladolid, Spain. ⁶ Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Valladolid, 47005, Valladolid, Spain.
Source: Letters in Drug Design & Discovery, Volume 1, Issue 4, Oct 2004, p. 361 - 367
DOI: https://doi.org/10.2174/1570180043398687
- Available online: 01 Oct 2004

Abstract

Conjugates containing nigrin b (two-chain RIP) linked to a new lectin (SELld) from Sambucus ebulus L. have been designed. They retain the anti-ribosomal inhibitory activity of nigrin b but, in contrast to nigrin b, they exerted strong cytotoxicity on COLO 320 and HeLa cells, which ran in parallel with DNA fragmentation.

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2004-10-01

2025-09-05

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Article Type: Review Article

Keyword(s): apoptosis; cancer therapy; colo 320 cells; nigrin b; ribosome-inactivating proteins; selld

Design and Cytotoxicity Analysis of a Conjugate Containing the New DGalactose- Binding Lectin SELld and the Non-Toxic Type 2 Ribosome- Inactivating Protein Nigrin b

Abstract

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