Cyclosporin A: A Therapeutic Strategy in Allergic Diseases

Nettis Eustachio; Colanardi M. Cristina; Ferrannini Antonio

doi:10.2174/1570180043398650

ISSN: 1570-1808
E-ISSN: 1875-628X

Cyclosporin A: A Therapeutic Strategy in Allergic Diseases
Authors: Nettis Eustachio¹, Colanardi M. Cristina² and Ferrannini Antonio³
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¹ Cattedra di Allergologia e Immunologia Clinica, Padiglione Chini - Policlinico, Piazza Giulio Cesare,70124 BARI, Italy. ² Cattedra di Allergologia e Immunologia Clinica, Padiglione Chini - Policlinico, Piazza Giulio Cesare,70124 BARI, Italy. ³ Cattedra di Allergologia e Immunologia Clinica, Padiglione Chini - Policlinico, Piazza Giulio Cesare,70124 BARI, Italy.
Source: Letters in Drug Design & Discovery, Volume 1, Issue 4, Oct 2004, p. 300 - 307
DOI: https://doi.org/10.2174/1570180043398650
- Available online: 01 Oct 2004

Abstract

Cyclosporin A (CsA) is a fungal metabolite that has immunomodulatory and anti-inflammatory effects. Cyclosporin binds to cyclophilin, inhibiting CD4-T-cell activation. In this paper we discuss the mechanism of action of CsA and its role as a novel approach for the treatment of allergic disease.

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2004-10-01

2025-09-04

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Article Type: Review Article

Keyword(s): allergic contact dermatitis; asthma; atopic dermatitis; cyclosporin; ocular allergic diseases; urticaria

Cyclosporin A: A Therapeutic Strategy in Allergic Diseases

Abstract

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