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2000
Volume 21, Issue 18
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background

Non-ionic surfactant-based vesicles (niosomes) as coherent and self-organization capability structures form organized core/shell nanostructures.

Objective

In this academic research, Ni/NiAlO core/shell nanostructures were successfully synthesized with the ultrasound-assisted direct micelle (UADM) method and these structures were used as a delivery system for minoxidil drugs.

Methods

The synthesis conditions for producing Ni/NiAlO core/shell structures were optimized using a design of experiments (DOE) approach. Process control was systematically examined through analysis of variance (ANOVA) and response surface methodology (RSM). The Ni/NiAlO, core/shell nanostructures, underwent characterization using various techniques such as SEM (scanning electron microscopy), TEM (transmission electron microscopy), AFM (atomic force microscopy), FT-IR (Fourier-transform infrared spectroscopy), TGA (thermogravimetric analysis), BET analysis, differential thermal analysis (DTA), and nitrogen adsorption isotherms. The release of minoxidil from the Ni/NiAlO core/shell nanostructures was studied using UV-vis spectroscopy at a wavelength of 486 nm.

Results

Results indicated an encapsulation efficiency (EE%) of around 74% after 150 minutes. Furthermore, the loading efficiency of minoxidil in niosomes modified with Ni/NiAlO core/shell nanostructures was calculated to be approximately 99.83% at 486 nm.

Conclusion

Overall, this research lays a foundational framework for developing innovative nanomaterials with tailored properties for advanced delivery systems and other novel applications.

© 2024 Bentham Science Publishers
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2024-12-16
2025-10-16

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Preparation and Evaluation of Ni/NiAl2O4 Core/Shell Nanostructures in Non-ionic Surfactant-based Vesicle
Letters in Drug Design & Discovery 21, 4500 (2024); https://doi.org/10.2174/0115701808346130241213093236
/content/journals/lddd/10.2174/0115701808346130241213093236
/content/journals/lddd/10.2174/0115701808346130241213093236
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  • Article Type:     Research Article
Keyword(s): design of experiments; efficient drug delivery; minoxidil; Ni/NiAl2O4 core/shell nanostructures; niosomes; transmission electron microscopy

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