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2000
Volume 25, Issue 4
  • ISSN: 1871-5265
  • E-ISSN: 2212-3989

Abstract

Introduction

Cervical cancer is among the most common types of cancer in women and is associated with human papillomavirus (HPV) infection. The association between cervical cancer and high-risk HPV infection has been well documented. However, the effect of simultaneous infection with high- and low-risk HPV or low-risk HPV alone on the risk of developing cervical malignancy remains unanswered in guidelines.

Methods

We investigated the association of high and low-risk HPVs (HR or LR) genotypes with cervical carcinoma risk and pathological and cytological information in cases recruited from a population-based cohort study of 790 patients. Correlation matrix and t-test were used for analysis.

Results

The percentage of HR+LR and HR-HPV16/18 were 9.30% and 11.20% in class II, 7.15% and 7.10% in class IV, and 7.15% and 5.80% in As-CUS smears.

Interestingly, concurrent infection with HR-HPV and LR-HPV types led to a significant reduction in the risk of developing malignancy compared to the high-risk group (OR=0.3 (0.098-0.925), -value=0.04). The percentage of individuals with cervical malignancy was 10.2% and 28.2% within the co-infected and the HR-HPV participants.

Conclusion

Our findings suggest that simultaneous infection with high- and low-risk HPV may reduce the risk of cervical malignancy.

© 2025 Bentham Science Publishers
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2025-10-28

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Interaction of High- and Low-Risk Human Papillomavirus Genotypes is Associated with a Reduced Risk of Developing Cervical Cancer
Infect. Disord. Drug Targets 25, E18715265307980 (2025); https://doi.org/10.2174/0118715265307980240826060516
/content/journals/iddt/10.2174/0118715265307980240826060516
/content/journals/iddt/10.2174/0118715265307980240826060516
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  • Article Type:     Research Article
Keyword(s): Cervical cancer; correlation matrix; high-risk HPV; human papillomavirus; low-risk HP; t-test analysis

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