Skip to content
2000
Volume 25, Issue 11
  • ISSN: 1871-5303
  • E-ISSN: 2212-3873

Abstract

Background

The involvement of the larynx in many situations can have a substantial impact on a person's voice, breathing, and general health. Individuals with autoimmune thyroid disorders can experience a variety of conditions affecting the larynx. Autoimmune thyroid disorders, such as Hashimoto's thyroiditis (HT) and Graves' disease (GD), are prevalent conditions affecting the thyroid gland. Beyond their established impact on thyroid function, these disorders have been associated with laryngeal involvement. The current study aims to explore the likelihood of laryngeal involvement in patients with Autoimmune Thyroid Disorders (AITD).

Methods

This study involved a retrospective analysis of medical records from patients diagnosed with autoimmune thyroid disorders. Inclusion criteria were a confirmed diagnosis through laboratory investigations and clinical assessment. Patients with pre-existing laryngeal pathologies or other conditions affecting the larynx were not considered. We collected data from 4 research articles and 3 clinical trials from Embase, PubMed, and NCBI-Trials portals, focusing on reported laryngeal symptoms. The severity of laryngeal involvement was assessed and categorized based on its extent and impact on vocal function.

Results

Preliminary analysis of the collected data indicated a significant proportion of patients with autoimmune thyroid disorders reporting laryngeal symptoms. Among these patients, various manifestations of laryngeal involvement were observed, including vocal changes, hoarseness, and throat discomfort.

Conclusion

The findings show that laryngeal symptoms may be an underappreciated feature of these diseases, potentially impacting vocal function and quality of life in affected people. Further research is also needed for more precise projections in this direction.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/emiddt/10.2174/0118715303304858240904042316
2024-09-23
2025-09-12

  • From This Site

    /content/journals/emiddt/10.2174/0118715303304858240904042316
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. KyritsiE.M. Kanaka-GantenbeinC. Autoimmune thyroid disease in specific genetic syndromes in childhood and adolescence.Front. Endocrinol.20201154310.3389/fendo.2020.00543 32973676
     [Google Scholar]
  2. KhanF.A. Al-JameilN. KhanM.F. Al-RashidM. TabassumH. Thyroid dysfunction: An autoimmune aspect.Int. J. Clin. Exp. Med.20158566776681 26221205
     [Google Scholar]
  3. VanderpumpM.P.J. The epidemiology of thyroid disease.Br. Med. Bull.2011991395110.1093/bmb/ldr030 21893493
     [Google Scholar]
  4. Ovčariček, P.P.; Görges, R.; Giovanella, L., Eds.; Autoimmune Thyroid Diseases. Seminars in Nuclear Medicine.Elsevier2023
     [Google Scholar]
  5. SaranacL. ZivanovicS. BjelakovicB. StamenkovicH. NovakM. KamenovB. Why is the thyroid so prone to autoimmune disease?Horm. Res. Paediatr.201175315716510.1159/000324442 21346360
     [Google Scholar]
  6. CastoC. PepeG. Li PomiA. CoricaD. AversaT. WasniewskaM. Hashimoto’s thyroiditis and graves’ disease in genetic syndromes in pediatric age.Genes202112222210.3390/genes12020222 33557156
     [Google Scholar]
  7. Khaleghzadeh-AhangarH. TalebiA. Mohseni-MoghaddamP. Thyroid disorders and development of cognitive impairment: A review study.Neuroendocrinology2022112983584410.1159/000521650 34963121
     [Google Scholar]
  8. TagoeC.E. ShethT. GolubE. SorensenK. Rheumatic associations of autoimmune thyroid disease: A systematic review.Clin. Rheumatol.20193871801180910.1007/s10067‑019‑04498‑1 30927115
     [Google Scholar]
  9. GeethaK. SasankaG. PridvineelS. BanuM.U. Rama RaoT. A review on hashimoto’s thyroiditis.J. Drug Deliv. Ther.2023131225025410.22270/jddt.v13i12.6133
     [Google Scholar]
  10. Jabrocka-HybelA. SkalniakA. PiątkowskiJ. PachD. Hubalewska-DydejczykA. How far are we from understanding the genetic basis of Hashimoto’s thyroiditis?Int. Rev. Immunol.201332333735410.3109/08830185.2012.755175 23617710
     [Google Scholar]
  11. MincerD.L. JialalI. Hashimoto thyroiditis. StatPearls.Treasure Island (FL)StatPearls Publishing2017
     [Google Scholar]
  12. LaneL.C. WoodC.L. CheethamT. Graves’ disease: Moving forwards.Arch. Dis. Child.2023108427628110.1136/archdischild‑2022‑323905 35831126
     [Google Scholar]
  13. DaviesT.F. AndersenS. LatifR. NagayamaY. BarbesinoG. BritoM. EcksteinA.K. Stagnaro-GreenA. KahalyG.J. Graves’ disease.Nat. Rev. Dis. Primers2020615210.1038/s41572‑020‑0184‑y 32616746
     [Google Scholar]
  14. McIverB. MorrisJ.C. The pathogenesis of Graves’ disease.Endocrinol. Metab. Clin. North Am.1998271738910.1016/S0889‑8529(05)70299‑1 9534029
     [Google Scholar]
  15. WongC.K.H. LuiD.T.W. XiongX. ChuiC.S.L. LaiF.T.T. LiX. WanE.Y.F. CheungC.L. LeeC.H. WooY.C. AuI.C.H. ChungM.S.H. ChengF.W.T. TanK.C.B. WongI.C.K. Risk of thyroid dysfunction associated with mRNA and inactivated COVID-19 vaccines: A population-based study of 2.3 million vaccine recipients.BMC Med.202220133910.1186/s12916‑022‑02548‑1 36229814
     [Google Scholar]
  16. HussainY.S. HookhamJ.C. AllahabadiaA. BalasubramanianS.P. Epidemiology, management and outcomes of Graves’ disease-real life data.Endocrine201756356857810.1007/s12020‑017‑1306‑5 28478488
     [Google Scholar]
  17. LoC.K.L. MertzD. LoebM. Newcastle-Ottawa scale: Comparing reviewers’ to authors’ assessments.BMC Med. Res. Methodol.20141414510.1186/1471‑2288‑14‑45 24690082
     [Google Scholar]
  18. KimY. SteinerP.M. Causal graphical views of fixed effects and random effects models.Br. J. Math. Stat. Psychol.202174216518310.1111/bmsp.12217 33063334
     [Google Scholar]
  19. BurgessS. ThompsonS.G. Interpreting findings from Mendelian randomization using the MR-Egger method.Eur. J. Epidemiol.201732537738910.1007/s10654‑017‑0255‑x 28527048
     [Google Scholar]
  20. VerhagenA.P. FerreiraM.L. Forest plots.J. Physiother.201460317017310.1016/j.jphys.2014.06.021 25084633
     [Google Scholar]
/content/journals/emiddt/10.2174/0118715303304858240904042316
Loading
Likelihood of Laryngeal Involvement in Autoimmune Thyroid Disorder Patients: A Meta-Analysis
Endocr Metab Immune Disord Drug Targets 25, 848 (2025); https://doi.org/10.2174/0118715303304858240904042316
/content/journals/emiddt/10.2174/0118715303304858240904042316
/content/journals/emiddt/10.2174/0118715303304858240904042316
Loading

Data & Media loading...

Supplements

PRISMA checklist is available as supplementary material on the publisher’s website along with the published article. Supplementary material is available on the publisher’s website along with the published article.

file format download Download

  • Article Type:     Research Article
Keyword(s): autoimmune diseases; graves' disease; hashimoto's thyroiditis; Laryngeal thyroid disorders; meta-analysis; vocal function

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test