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2000
Volume 25, Issue 11
  • ISSN: 1871-5303
  • E-ISSN: 2212-3873
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Abstract

Neonates exhibit pain responses characterized by various endocrinal changes, including alterations in cortisone and oxytocin serum levels, as well as physiological and emotional reactions. The administration of neonatal pain management leads to the normalization of endocrine hormones, including cortisone and oxytocin, which are affected by the presence of neonatal pain. Diagnosing neonatal pain is complex; however, effective management is essential. An adequate balance should be established between the analgesics used for pain management and their associated side effects. Uncontrolled neonatal pain is correlated with delayed development with increased neurologic insult. This review aims to examine the significance of neonatal pain, along with its clinical and physical manifestations. It also explores strategies for managing neonatal pain, encompassing both pharmacological and non-pharmacological methods, along with the particular medications utilized in pharmacological interventions. This discussion includes various non-pharmacological methods for managing neonatal pain. Additionally, this review examines methods for pain assessment. The aim is to highlight the significance of pain in this vulnerable population and to promote the implementation of diverse management strategies for neonatal pain to prevent serious yet avoidable, adverse effects in neonates.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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References

  1. VisoiuM. Evolving approaches in neonatal postoperative pain management.Semin. Pediatr. Surg.202231415120310.1016/j.sempedsurg.2022.15120336038217
     [Google Scholar]
  2. AhsanM.S. KalamdaniP. KalathingalT. PatraS. ManerkarS. MondkarJ. Evaluation of pain and physiological stress during targeted neonatal echocardiography.J. Neonatal Perinatal Med.2022151899310.3233/NPM‑21078234334429
     [Google Scholar]
  3. IlhanE. PaceyV. BrownL. SpenceK. van GanzewinkelC. Pillai RiddellR. Campbell-YeoM. StevensB.J. ErikssonM. ShahV. AnandK.J.S. BellieniC. DalyM. JohnstonC. HushJ. What is the definition of acute episodic and chronic pain in critically ill neonates and infants? A global, four-stage consensus and validation study.BMJ Open2022123e05525510.1136/bmjopen‑2021‑05525535264356
     [Google Scholar]
  4. McPhersonC. GrunauR.E. Pharmacologic analgesia and sedation in neonates.Clin. Perinatol.202249124326510.1016/j.clp.2021.11.01435210004
     [Google Scholar]
  5. PengN.H. LeeM.C. SuW.L. LeeC.H. ChenC.H. ChangY.C. HuangC.H. Knowledge, attitudes and practices of neonatal professionals regarding pain management.Eur. J. Pediatr.202118019910710.1007/s00431‑020‑03718‑032556509
     [Google Scholar]
  6. SoaresJ.C.A. BarrosM.C.M. da SilvaG.V.T. CarliniL.P. HeiderichT.M. OrsiR.N. BaldaR.C.X. SilvaP.A.S.O. ThomazC.E. GuinsburgR. Looking at neonatal facial features of pain: Do health and non-health professionals differ?J. Pediatr.202298440641210.1016/j.jped.2021.10.00634914897
     [Google Scholar]
  7. CastagnoE. FabianoG. CarmellinoV. CerchioR. De VitoB. LauriaB. MercurioG. CosciaA. PonteG. BondoneC. Neonatal pain assessment scales: Review of the literature.Prof. Inferm.2022751172836962062
     [Google Scholar]
  8. SarkariaE. GruszfeldD. Assessing neonatal pain with NIPS and COMFORT-B: Evaluation of NICU’s staff competences.Pain Res. Manag.202220221910.1155/2022/854537235340544
     [Google Scholar]
  9. OlssonE. AhlH. BengtssonK. VejayaramD.N. NormanE. BruschettiniM. ErikssonM. The use and reporting of neonatal pain scales: A systematic review of randomized trials.Pain2021162235336010.1097/j.pain.000000000000204632826760
     [Google Scholar]
  10. HeiderichT.M. CarliniL.P. BuzutiL.F. BaldaR.C.X. BarrosM.C.M. GuinsburgR. ThomazC.E. Face-based automatic pain assessment: Challenges and perspectives in neonatal intensive care units.J. Pediatr.202399654656010.1016/j.jped.2023.05.00537331703
     [Google Scholar]
  11. ZhouX. ZhouK. YangM. WuH. ChenQ. LiT. ZengJ. LiD. OuY. WuY. Assessment and management of neonatal pain: A best practice implementation project.JBI Evid. Implement.2023211687710.1097/XEB.000000000000035436374976
     [Google Scholar]
  12. NeshatH. HassankhaniH. JabraeiliM. NegarandehR. Organisational challenges of pain management in neonatal intensive care unit: A qualitative study.BMJ Open2023139e07269510.1136/bmjopen‑2023‑07269537669843
     [Google Scholar]
  13. LuoF. ZhuH. MeiL. ShuQ. ChengX. ChenX. ZhaoY. ChenS. PanY. Evaluation of procedural pain for neonates in a neonatal intensive care unit: A single-centre study.BMJ Paediatr. Open202371e00210710.1136/bmjpo‑2023‑00210737821124
     [Google Scholar]
  14. IlhanE. PaceyV. BrownL. SpenceK. GrayK. RowlandJ.E. WhiteK. HushJ.M. Neonates as intrinsically worthy recipients of pain management in neonatal intensive care.Med. Health Care Philos.2021241657210.1007/s11019‑020‑09982‑z33034802
     [Google Scholar]
  15. BarrosM.C.M. ThomazC.E. da SilvaG.V.T. do Carmo Azevedo SoaresJ. CarliniL.P. HeiderichT.M. OrsiR.N. BaldaR.C.X. SilvaP.A.S.O. SanudoA. AndreoniS. GuinsburgR. Identification of pain in neonates: The adults’ visual perception of neonatal facial features.J. Perinatol.20214192304230810.1038/s41372‑021‑01143‑134253842
     [Google Scholar]
  16. DeviR. PriyadarshiM. SinghP. ChaurasiaS. BasuS. Neonatal pain response to various heel prick devices: A randomized controlled trial.Indian Pediatr.2023601189389810.1007/s13312‑023‑3032‑937551876
     [Google Scholar]
  17. FatollahzadeM. ParviziS. KashakiM. HaghaniH. Alinejad- NaeiniM. The effect of gentle human touch during endotracheal suctioning on procedural pain response in preterm infant admitted to neonatal intensive care units: A randomized controlled crossover study.J. Matern. Fetal Neonatal Med.20223571370137610.1080/14767058.2020.175564932316790
     [Google Scholar]
  18. LavergneJ. LangmanE. MansellD. DolJ. WestC. BenoitB. Procedural pain assessment in neonates at risk of neonatal opioid withdrawal syndrome: A scoping review protocol.JBI Evid. Synth.202321102107211410.11124/JBIES‑22‑0041437232693
     [Google Scholar]
  19. SawleshwarkarK. SinghM. BajajR. LoyaS. ChikhlondheR. BhaveS. Implementing use of sucrose analgesia (non-pharmacological management of neonatal pain) in a standalone private facility level 3 neonatal care unit using point of care quality improvement methodology.BMJ Open Qual.202211Suppl. 1e00183010.1136/bmjoq‑2022‑00183035705258
     [Google Scholar]
  20. MerterO.S. BolişikZ.B. The effects of manual and automatic lancets on neonatal capillary heel blood sampling pain: A prospective randomized controlled trial.J. Pediatr. Nurs.202158e8e1210.1016/j.pedn.2020.11.01533303279
     [Google Scholar]
  21. WalasW. HalabaZ. Latka-GrotJ. PiotrowskiA. Available instruments to assess pain in infants.Neoreviews20212210e644e65210.1542/neo.22‑10‑e64434599062
     [Google Scholar]
  22. FranciscoA.S.P.G. MontemezzoD. RibeiroS.N.S. FrataB. MenegolN.A. OkuboR. SonzaA. SanadaL.S. Positioning effects for procedural pain relief in NICU: Systematic review.Pain Manag. Nurs.202122212113210.1016/j.pmn.2020.07.00632863161
     [Google Scholar]
  23. GlenzelL. do Nascimento OliveiraP. MarchiB.S. CecconR.F. MoranC.A. Validity and reliability of pain and behavioral scales for preterm infants: A systematic review.Pain Manag. Nurs.2023245e84e9610.1016/j.pmn.2023.06.01037524611
     [Google Scholar]
  24. TheuboM. O’ReillyD. ForanA. No pain, neurodevelopmental gain: Time to avoid painful placebo injections in neonatal research.Acta Paediatr.202211181476147810.1111/apa.1636935451100
     [Google Scholar]
  25. van den AnkerJ.N. Pharmacological treatment of neonatal pain: Are we ready for a paradigm shift?Br. J. Anaesth.20211264e135e13610.1016/j.bja.2021.01.01233583578
     [Google Scholar]
  26. LinT. QiuH. HuangR. ZhangT. HarrisonD. There are already enough studies on sweet solutions for neonatal procedural pain and more would be unethical and unnecessary.Acta Paediatr.202311271434143610.1111/apa.1678437022285
     [Google Scholar]
  27. AkbariN. MutluB. NadaliJ. Effect of non-nutritive sucking during heel-stick procedure in pain management of term infants in the neonatal intensive care unit: A systematic review and meta-analysis.Curr. Pediatr. Rev.2022191909835410609
     [Google Scholar]
  28. DionysakopoulouC. LianouL. BoutopoulouB. GiannakopoulouM. VlachiotiE. KoumpagiotiD. BozasE. MatziouV. The role of substance P, neurokinin A, neuropeptide Y, and cortisol in assessing neonatal pain.Neonatal Netw.2023422657110.1891/NN.2022‑000636868802
     [Google Scholar]
  29. ten BargeJ.A. van den BoschG.E. MeestersN.J. AllegaertK. ArribasC. CavallaroG. GarridoF. RaffaeliG. VermeulenM.J. SimonsS.H.P. Current pain management practices for preterm infants with necrotizing enterocolitis: A European survey.Pediatr. Res.202394255556310.1038/s41390‑023‑02508‑236828969
     [Google Scholar]
  30. DevsamB.U. KinneyS. The clinical utility of the pain assessment tool in ventilated, sedated, and muscle-relaxed neonates.Aust. Crit. Care202134433333910.1016/j.aucc.2020.09.00533223388
     [Google Scholar]
  31. AranhaV.P. ChahalA. BhardwajA.K. Short-term effects of multimodal stimulation on neuromotor behaviour and neonatal pain among hospitalized preterm infants: A feasibility, non-blinded randomized controlled trial.J. Neonatal Perinatal Med.202316232533710.3233/NPM‑21088934864695
     [Google Scholar]
  32. BogginiT. PozzoliS. SchiavolinP. ErarioR. MoscaF. BrambillaP. FumagalliM. Cumulative procedural pain and brain development in very preterm infants: A systematic review of clinical and preclinical studies.Neurosci. Biobehav. Rev.202112332033610.1016/j.neubiorev.2020.12.01633359095
     [Google Scholar]
  33. CannavòL. PerroneS. MarsegliaL. ViolaV. Di RosaG. GittoE. Potential benefits of melatonin to control pain in ventilated preterm newborns: An updated review.Pain Pract.202222224825410.1111/papr.1306934431588
     [Google Scholar]
  34. AnneR.P. DeshabhotlaS. AhmedS.W. AhmedS.J. ReddyN. FarooquiD. OletiT.P. A quality improvement initiative to improve management of procedural pain in preterm neonates.Paediatr. Anaesth.202131222122910.1111/pan.1407533188650
     [Google Scholar]
  35. HashemiH. CohenE. RiddellR.P. The importance of managing acute pain in the neonatal intensive care unit context.Indian Pediatr.2023601188788810.1007/s13312‑023‑3030‑y37950464
     [Google Scholar]
  36. ShahP.S. TorgalkarR. ShahV.S. Breastfeeding or breast milk for procedural pain in neonates.Cochrane Database Syst. Rev.202388CD00495037643989
     [Google Scholar]
  37. KearnsR.J. LucasD.N. Neuraxial analgesia in labour and the foetus.Baillieres. Best Pract. Res. Clin. Anaesthesiol.2023371738610.1016/j.bpa.2023.02.00537295856
     [Google Scholar]
  38. AlbericeR.M.C. SilvaS.C.O. LeiteA.C.C. ManzoB.F. SimãoD.A.S. MarcattoJ.O. Assessment of newborn pain during arterial puncture: an observational analytical study.Rev. Bras. Ter. Intensiva202133343443910.5935/0103‑507X.2021005835107555
     [Google Scholar]
  39. Bachiller CarniceroL. Antoñón RodríguezM. de la Huerga LópezA. Martín RamosS. Morales LuengoF. Marín UrueñaS.I. Caserío CarboneroS. Parasympathetic evaluation for procedural pain assessment in neonatology.An Pediatr202297639039710.1016/j.anpede.2022.08.013
     [Google Scholar]
  40. KyololoO.B.M. StevensB.J. SongokJ. Procedural pain in hospitalized neonates in Kenya.J. Pediatr. Nurs.202158152010.1016/j.pedn.2020.11.00733279820
     [Google Scholar]
  41. Maya-EneroS. Fàbregas-MitjansM. Llufriu-MarquèsR.M. Candel-PauJ. Garcia-GarciaJ. López-VílchezM.Á. Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: A randomized clinical trial (NCT04867824).Eur. J. Pediatr.2022181113923392910.1007/s00431‑022‑04608‑336076107
     [Google Scholar]
  42. FalsaperlaR. CollottaA.D. SpatuzzaM. FamiliariM. VitalitiG. RuggieriM. Evidences of emerging pain consciousness during prenatal development: A narrative review.Neurol. Sci.20224363523353210.1007/s10072‑022‑05968‑235246816
     [Google Scholar]
  43. SharmaN. SamuelA.J. Multisensory stimulation and soft tissue therapy on pain and neurodevelopment among preterm neonates.Pediatr. Phys. Ther.202234227728210.1097/PEP.000000000000088735385466
     [Google Scholar]
  44. BresestiI. VanzùG. RedaelliF. DanieleI. ZuccottiG.V. CerritelliF. ListaG. FabianoV. New perspective for pain control in neonates: A comparative effectiveness research.J. Perinatol.20214192298230310.1038/s41372‑021‑01025‑633664472
     [Google Scholar]
  45. LiuJ. FangS. WangY. GaoL. XinT. LiuY. The effectiveness of massage interventions on procedural pain in neonates: A systematic review and meta-analysis.Medicine202210141e3093910.1097/MD.000000000003093936254036
     [Google Scholar]
  46. VederhusB.J. OlsenM.S. EideG.E. StormH. GutheH.J. ALPS - N eo pain and stress assessment scale for neonates—A measure for procedural pain.Acta Paediatr.202311261220122510.1111/apa.1675936938888
     [Google Scholar]
  47. De Clifford-FaugèreG. AitaM. ArbourC. ColsonS. Development, evaluation and adaptation of a critical realism informed theory of procedural pain management in preterm infants: The PAIN-Neo theory.J. Adv. Nurs.20237962155216610.1111/jan.1552536464778
     [Google Scholar]
  48. SrivastavaG. GargA. ChhaviN. FaridiM.M.A. Effect of kangaroo mother care on pain during orogastric tube insertion in low-birthweight newborns: An open label, randomised trial.J. Paediatr. Child Health202258122248225310.1111/jpc.1621236131630
     [Google Scholar]
  49. JinL. ZhangJ. YangX. RongH. Maternal voice reduces procedural pain in neonates: A meta-analysis of randomized controlled trials.Medicine202310212e3306010.1097/MD.000000000003306036961138
     [Google Scholar]
  50. ChenY. LiY. SunJ. HanD. FengS. ZhangX. The effect of maternal voice on venipuncture induced pain in neonates: A randomized study.Pain Manag. Nurs.202122566867310.1016/j.pmn.2021.01.00233674242
     [Google Scholar]
  51. De Clifford FaugèreG. AitaM. FeeleyN. ColsonS. Nurses’ perception of preterm infants’ pain and the factors of their pain assessment and management.J. Perinat. Neonatal. Nurs.2022363312326
     [Google Scholar]
  52. Yavanoglu AtayF. GuranO. SahinO. CakmakF. ColakD. Mungan Akınİ. Pain during PICC insertion in preterm infants: The needle is not the only problem.J. Matern. Fetal Neonatal Med.2023361222220510.1080/14767058.2023.222220537303207
     [Google Scholar]
  53. OlszewskaM. Pointinger-TomasikS. KwintaP. Assessment of salivary cortisol concentrations for procedural pain monitoring in newborns.J. Perinat. Med.202351456457210.1515/jpm‑2022‑032036282969
     [Google Scholar]
  54. Avila-AlvarezA. Pertega-DiazS. Vazquez GomezL. Sucasas AlonsoA. Romero ReyH. Eiriz BarbeitoD. Cabana VazquezM. Pain assessment during eye examination for retinopathy of prematurity screening: Skin conductance versus PIPP-R.Acta Paediatr.2020109593594210.1111/apa.1506631630433
     [Google Scholar]
  55. SharmaN. SamuelA.J. Multisensory stimulation as a non-pharmacological intervention for neonates undergoing painful procedures: A scoping review.J. Neonatal Perinatal Med.202215467768710.3233/NPM‑22108736189504
     [Google Scholar]
  56. PatelD.V. SoniS.N. ShuklaV.V. PhatakA.G. ShindeM.K. NimbalkarA.S. NimbalkarS.M. Efficacy of skin-to-skin care versus swaddling for pain control associated with vitamin K administration in full-term neonates: A randomized controlled trial.J. Trop. Pediatr.2022684fmac05210.1093/tropej/fmac05235737952
     [Google Scholar]
  57. ShykhveisiF. Jafarian AmiriR. ZabihiA. Haghshenas MojaveriM. ArzaniA. ChehraziM. ChariZ.V. Effect of eye shield and ear muffs on pain intensity during venous blood sampling in premature infants: A clinical trial study.BMC Pediatr.202323116110.1186/s12887‑023‑03978‑337024882
     [Google Scholar]
  58. SawantT. ManerkarS. PatraS. KalamdaniP. KalathingalT. MondkarJ. Pain and physiological stress during minimally invasive surfactant therapy (MIST) in very preterm infants.Indian Pediatr.202360755756010.1007/s13312‑023‑2935‑937032545
     [Google Scholar]
  59. AyyıldızT.K. TanrıverdiE. TankD.Y. AkkoçB. TopanA. The effect of swaddling method applied to preterm infants during the aspiration procedure on pain.J. Pediatr. Nurs.202370616710.1016/j.pedn.2022.05.02536801626
     [Google Scholar]
  60. PollaciM. SchlenkE.A. BaumC. GodfreyK. Supportive interventions to reduce pain and stress during ophthalmic examinations for retinopathy of prematurity in premature infants.Adv. Neonatal Care202121427427910.1097/ANC.000000000000080333278104
     [Google Scholar]
  61. StadlerJ. AvianA. PichlerG. PoschK. UrlesbergerB. RaithW. Laser acupuncture versus oral glucose administration for pain prevention in term neonates: An observer-blinded non-inferiority randomized controlled clinical trial.Acupunct. Med.202139658959510.1177/0964528421100954434088224
     [Google Scholar]
  62. LanH.Y. YangL. LinC.H. HsiehK.H. ChangY.C. YinT. Breastmilk as a multisensory intervention for relieving pain during newborn screening procedures: A randomized control trial.Int. J. Environ. Res. Public Health202118241302310.3390/ijerph18241302334948633
     [Google Scholar]
  63. GaoH. XuG. LiF. LvH. RongH. MiY. LiM. Effect of combined pharmacological, behavioral, and physical interventions for procedural pain on salivary cortisol and neurobehavioral development in preterm infants: A randomized controlled trial.Pain2021162125326210.1097/j.pain.000000000000201532773596
     [Google Scholar]
  64. FerreiraE.A.L. ValeteC.O.S. NassifD.S. de BarrosG.A.M. Type of delivery and pain response in full-term newborns after vitamin K administration: Assessment using the COMFORT behavior and neonatal facial coding system scales.Braz. J. Anesthesiol.202373223223310.1016/j.bjane.2022.10.00536356709
     [Google Scholar]
  65. KimJ. ChoiS.J. Effect of olfactory stimulation with breast milk on pain responses to heel stick in premature infants: A randomized controlled trial.Breastfeed. Med.202217760561010.1089/bfm.2021.037435384714
     [Google Scholar]
  66. ReddyS. NesargiS.V. StevensS. JoseJ. BabuH. Procedural analgesia in the neonatal intensive care unit: A quality improvement initiative.Am. J. Perinatol.202239151688169210.1055/s‑0041‑172612133706395
     [Google Scholar]
  67. FitriS.Y.R. LusmilasariL. JuffrieM. BellieniC.V. Modified sensory stimulation using breastmilk for reducing pain intensity in neonates in Indonesia: A randomized controlled trial.J. Pediatr. Nurs.202053e199e20310.1016/j.pedn.2020.04.00432402558
     [Google Scholar]
  68. TuranO. AkkoyunI. InceD.A. DoganayB. TugcuA.U. EcevitA. Effect of breast milk and sucrose on pain and perfusion index during examination for retinopathy of prematurity.J. Matern. Fetal Neonatal Med.20213471138114210.1080/14767058.2019.162820931203685
     [Google Scholar]
  69. SharmaN. SamuelA.J. A systematic review of multisensory stimulation on procedural pain among preterm neonates.Pediatr. Phys. Ther.202335328629110.1097/PEP.000000000000101237276195
     [Google Scholar]
  70. ShayaniL.A. MarãesV.R.F.S. Manual and alternative therapies as non-pharmacological interventions for pain and stress control in newborns: A systematic review.World J. Pediatr.2023191354710.1007/s12519‑022‑00601‑w36100797
     [Google Scholar]
  71. HowardC. PowellA.S. PavlidisE. PavelA. FinnD. AllenA. Olavarria-RamirezL. ClarkeG. LivingstoneV. BoylanG.B. DempseyE.M. No effect of a musical intervention on stress response to venepuncture in a neonatal population.Acta Paediatr.2020109351151710.1111/apa.1501831532835
     [Google Scholar]
  72. CoboM.M. MoultrieF. HauckA.G.V. CrankshawD. MonkV. HartleyC. Evans FryR. RobinsonS. van der VaartM. BaxterL. AdamsE. PoorunR. BhattA. SlaterR. Multicentre, randomised controlled trial to investigate the effects of parental touch on relieving acute procedural pain in neonates (Petal).BMJ Open2022127e06184110.1136/bmjopen‑2022‑06184136250332
     [Google Scholar]
  73. Maya-EneroS. Fàbregas-MitjansM. Llufriu-MarquèsR.M. Candel-PauJ. Garcia-GarciaJ. López-VílchezM.Á. Analgesic effect of inhaled lavender essential oil for frenotomy in healthy neonates: A randomized clinical trial.World J. Pediatr.202218639840310.1007/s12519‑022‑00531‑735377106
     [Google Scholar]
  74. RecherM. BoukhrisM.R. JeanneM. StormeL. LeteurtreS. SabourdinN. De jonckheereJ. The newborn infant parasympathetic evaluation in pediatric and neonatology: A literature review.J. Clin. Monit. Comput.202135595996610.1007/s10877‑021‑00670‑833590418
     [Google Scholar]
  75. KavurtS. ArslanZ. UnalS. BasA.Y. DemirelN. The effect of oscillometric blood pressure measurement on pain response in preterm infants.J. Paediatr. Child Health202359111251125510.1111/jpc.1649037694507
     [Google Scholar]
  76. Campbell-YeoM. BenoitB. NewmanA. JohnstonC. BardouilleT. StevensB. JiangA. The influence of skin-to-skin contact on cortical activity during Painful procedures in preterm infants in the neonatal intensive care unit (iCAP mini): Study protocol for a randomized control trial.Trials202223151210.1186/s13063‑022‑06424‑435725632
     [Google Scholar]
  77. MeninD. DondiM. Methodological issues in the study of the development of pain responsivity in preterm neonates: A systematic review.Int. J. Environ. Res. Public Health20201710350710.3390/ijerph1710350732429581
     [Google Scholar]
  78. KuderavaZ. KozarM. VisnovcovaZ. FerencovaN. TonhajzerovaI. PrsovaL. ZibolenM. Sympathetic nervous system activity and pain-related response indexed by electrodermal activity during the earliest postnatal life in healthy term neonates.Physiol. Res.202372339340110.33549/physiolres.93506137449751
     [Google Scholar]
  79. VelumulaP.K. ElbakoushF. TabbC.II FarooqiA. Lulic-BoticaM. JaniS. NatarajanG. BajajM. Breast milk vs 24% sucrose for procedural pain relief in preterm neonates: A non-inferiority randomized controlled trial.J. Perinatol.202242791491910.1038/s41372‑022‑01352‑235197549
     [Google Scholar]
  80. Sezer EfeY. ErdemE. CanerN. GüneşT. The effect of gentle human touch on pain, comfort and physiological parameters in preterm infants during heel lancing.Complement. Ther. Clin. Pract.20224810162210.1016/j.ctcp.2022.10162235759976
     [Google Scholar]
  81. KamataM. TobiasJ.D. Remifentanil: Applications in neonates.J. Anesth.201630344946010.1007/s00540‑015‑2134‑526758072
     [Google Scholar]
  82. NayakR. NagarajK.N. GururajG. Prevention of pain during screening for retinopathy of prematurity: A randomized control trial comparing breast milk, 10% Dextrose and sterile water.Indian J. Pediatr.202087535335810.1007/s12098‑020‑03182‑631989459
     [Google Scholar]
  83. YilmazD. InalS. Effects of three different methods used during heel lance procedures on pain level in term neonates.Jpn. J. Nurs. Sci.2020174e1233810.1111/jjns.1233832239753
     [Google Scholar]
  84. GüvenŞ.D. Çakırer ÇalbayramN. The effect of Helfer skin tap technique on hepatitis B vaccine intramuscular injection pain in neonates: A randomized controlled trial.Explore (NY)202319223824210.1016/j.explore.2022.09.00136115789
     [Google Scholar]
  85. Balice-BourgoisC. Zumstein-ShahaM. VanoniF. JaquesC. NewmanC.J. SimonettiG.D. A systematic review of clinical practice guidelines for acute procedural pain on neonates.Clin. J. Pain202036539039810.1097/AJP.000000000000080831977372
     [Google Scholar]
  86. AvcinE. KucukogluS. The effect of breastfeeding, kangaroo care, and facilitated tucking positioning in reducing the pain during heel stick in neonates.J. Pediatr. Nurs.20216141041610.1016/j.pedn.2021.10.00234687988
     [Google Scholar]
  87. TalebiM. AmiriS.R.J. RoshanP.A. ZabihiA. ZahedpashaY. ChehraziM. The effect of concurrent use of swaddle and sucrose on the intensity of pain during venous blood sampling in neonate: A clinical trial study.BMC Pediatr.202222126310.1186/s12887‑022‑03323‑035538448
     [Google Scholar]
  88. KumarS. PriyadarshiM. SinghP. PallapothuB. ChaurasiaS. BasuS. Correlation of clinical pain scores with cerebral oxygenation in preterm neonates during acute painful procedures: A prospective observational study.J. Perinatol.202343558458910.1038/s41372‑022‑01543‑x36271296
     [Google Scholar]
  89. BuenoM. StevensB. RaoM. RiahiS. Campbell-YeoM. CarrierL. BenoitB. Implementation and evaluation of the premature infant pain profile-revised (PIPP-R) e-learning module for assessing pain in infants.Clin. J. Pain202137537237810.1097/AJP.000000000000092533830093
     [Google Scholar]
  90. UpadhyayJ. KumarS. SinghP. BasuS. Cortical hemodynamic activity and pain perception during insertion of feeding tubes in preterm neonates: A randomized controlled cross-over trial.J. Perinatol.202242112112510.1038/s41372‑021‑01166‑834285360
     [Google Scholar]
  91. Swenson SchalkwykA. FlahertyJ. HessD. HorvathB. Erector spinae catheter for post-thoracotomy pain control in a premature neonate.BMJ Case Rep.2020139e23448010.1136/bcr‑2020‑23448032900720
     [Google Scholar]
  92. HoA.M.H. TorbickiE. WinthropA.L. KolarM. ZalanJ.E. MacLeanG. MizubutiG.B. Caudal catheter placement for repeated epidural morphine doses after neonatal upper abdominal surgery.Anaesth. Intensive Care2022501-214114510.1177/0310057X21106224035172612
     [Google Scholar]
  93. XiongP. YuX. Comment on: Intervention strategies for white noise alleviating procedural pain in newborns.J. Clin. Nurs.20233221-22792010.1111/jocn.1686237661385
     [Google Scholar]
  94. OlszewskaM. KwintaP. The influence of repeated pain exposure on morning salivary cortisol in term and preterm neonates.Pediatr. Endocrinol. Diabetes Metab.20232914910.5114/pedm.2022.12137036734392
     [Google Scholar]
  95. PalomaaA.K. TuomikoskiA.M. HuhtalaS. PölkkiT. Effectiveness of technology-based interventions compared with other non-pharmacological interventions for relieving procedural pain in hospitalized neonates: A systematic review protocol.JBI Evid. Synth.202119102770277610.11124/JBIES‑21‑0001034310486
     [Google Scholar]
  96. Versaw-BarnesD. KhoshbachtY.B. MorsbachS. Commentary on “A systematic review of multisensory stimulation on procedural pain among preterm neonates”.Pediatr. Phys. Ther.202335329210.1097/PEP.000000000000102937399298
     [Google Scholar]
  97. Apaydin CirikV. GülU. KihtirZ. ArayiciS. EfeE. ÇakmakH. ÇalişkanF. The effect of using maternal voice, white noise, and holding combination interventions on the heel stick sampling.J. Pediatr. Nurs.20237011110.1016/j.pedn.2023.01.00536738536
     [Google Scholar]
  98. VykolV. WilsonJ. GoodwinJ. Improving consistency in the use of sucrose with comfort measures during minor painful procedures.Adv. Neonatal Care2023231101610.1097/ANC.000000000000099535421005
     [Google Scholar]
  99. ErkutZ. MutluB. ÇakıcıM. The effect of 3 positions given to preterm infants during heelstick procedure on pain and durations of crying and procedure.J. Perinat. Neonatal. Nurs.2021352188195
     [Google Scholar]
  100. VenkatachariM. BabuT.A. BasuS. Variables impacting pain perception with various heel prick devices in neonates.Indian Pediatr.2023601196396410.1007/s13312‑023‑3053‑437950479
     [Google Scholar]
  101. Dersch-MillsD. HowlettA. LindJ. MarchukA. MohammadK. Impact of dexmedetomidine in conjunction with a weaning protocol on post-surgical opioid use in a neonatal intensive care unit.Pharmacotherapy202343763263710.1002/phar.278736862038
     [Google Scholar]
  102. GibbinsS. StevensB. HodnettE. PinelliJ. OhlssonA. DarlingtonG. Efficacy and safety of sucrose for procedural pain relief in preterm and term neonates.Nurs. Res.200251637538210.1097/00006199‑200211000‑0000512464757
     [Google Scholar]
  103. GoubetN. RattazC. PierratV. Comment on De Clifford- Faugere et al. (2020) ‘Systematic review and meta-analysis of olfactive stimulation interventions to manage procedural pain in preterm and full-term’.Int. J. Nurs. Stud.202213310429910.1016/j.ijnurstu.2022.10429935696808
     [Google Scholar]
  104. Haslund-KrogS. BarryJ.M. BirnbaumA.K. DalhoffK. Brink HenriksenT. SherwinC.M.T. AvachatC. PoulsenS. ChristensenU. RemmelR.P. WilkinsD. van den AnkerJ.N. HolstH. Pharmacokinetics and safety of prolonged paracetamol treatment in neonates: An interventional cohort study.Br. J. Clin. Pharmacol.202389113421343110.1111/bcp.1583437353311
     [Google Scholar]
  105. HurleyA. HarrisonC.M. Kangaroo care was as effective as sucrose for painful procedures for babies in the neonatal intensive care unit.Arch. Dis. Child. Educ. Pract. Ed.2020105531731810.1136/archdischild‑2019‑31809531630135
     [Google Scholar]
  106. SanatkarM. Dastjani FarahaniA. BazvandF. Ketamine analgesia as an alternative to general anesthesia during laser treatment for retinopathy of prematurity.J. Pediatr. Ophthalmol. Strabismus202259641642110.3928/01913913‑20220225‑0135446192
     [Google Scholar]
  107. BarandouziZ.A. KeshavarzM. MontazeriA. AshayeriH. RajaeiZ. Comparison of the analgesic effect of oral sucrose and/or music in preterm neonates: A double-blind randomized clinical trial.Complement. Ther. Med.20204810227110.1016/j.ctim.2019.10227131987233
     [Google Scholar]
  108. LiaoJ. FanJ. LiM. Analgesic effect and safety of lidocaine liposome vs oral sucrose water in blood collection and intramuscular injection in neonates.Altern. Ther. Health Med.202329115616236074963
     [Google Scholar]
  109. GurbuzH. DemirelA. OzcakirE. Erector spinae plane block for management of major abdominal and thoracoscopic surgeries in two low-birth-weight preterm neonates.Minerva Anestesiol.202187784084210.23736/S0375‑9393.21.15579‑833688699
     [Google Scholar]
  110. RellandL.M. NeelM.L. GehredA. MaitreN.L. Regional anesthesia in neonates and infants outside the immediate perioperative period: A systematic review of studies with efficacy and safety considerations.Paediatr. Anaesth.202131213214410.1111/pan.1404233070411
     [Google Scholar]
  111. FulkoskiN. KecskesZ. ChaudhariT. Minor painful procedures in extremely preterm infants admitted to a tertiary neonatal intensive care unit: Opportunities to improve pain mitigation.J. Paediatr. Child Health202359354254710.1111/jpc.1635236710604
     [Google Scholar]
  112. DenizA.Ö. AçikgözA. A randomized controlled trial: The effect of acupressure and foot reflexology on pain during heel-lancing in neonates.Clin. Nurs. Res.202332230631210.1177/1054773821106181534955035
     [Google Scholar]
  113. McPhersonC. OrtinauC.M. VesoulisZ. Practical approaches to sedation and analgesia in the newborn.J. Perinatol.202141338339510.1038/s41372‑020‑00878‑733250515
     [Google Scholar]
  114. An investigation on the cognition of neonatal pain assessment and analgesia management among medical staff in the neonatal intensive care unit.Zhongguo Dang Dai Er Ke Za Zhi202123121271127634911612
     [Google Scholar]
  115. AdiguzelH. EgilmezM. ErgunN. SarikabadayiY.U. ElbasanB. The effects of different procedures on pain levels in preterm and term infants in neonatal intensive care unit: A cross-sectional survey of pain assessment in newborns.Ir. J. Med. Sci.202319231001100710.1007/s11845‑022‑03183‑836264531
     [Google Scholar]
  116. PouraboliB. MirlashariJ. FakhrA.S. RanjbarH. AshtariS. The effect of facilitated tucking on the pain intensity induced by chest tube removal in infants.Adv. Neonatal Care202222546747210.1097/ANC.000000000000093634387216
     [Google Scholar]
  117. AbdelmageedR.I. YoussefA.M. EL-FarrashR.A. MohamedH.M. AbdelazizA.W. Measurement of cumulative preterm neonatal and maternal stressors during neonatal intensive care unit admission.J. Pediatr. Psychol.202247559560510.1093/jpepsy/jsab12435552433
     [Google Scholar]
  118. BucseaO. RupawalaM. ShiffI. WangX. MeekJ. FitzgeraldM. FabriziL. Pillai RiddellR. JonesL. Clinical thresholds in pain-related facial activity linked to differences in cortical network activation in neonates.Pain202316451039105010.1097/j.pain.000000000000279836633530
     [Google Scholar]
  119. MenegolN.A. RibeiroS.N.S. OkuboR. GulondaA.S.G.F. SonzaA. MontemezzoD. SanadaL.S. Quality assessment of neonatal pain scales translated and validated to Brazilian Portuguese: A systematic review of psychometric properties.Pain Manag. Nurs.202223455956510.1016/j.pmn.2021.12.00335078712
     [Google Scholar]
  120. RupawalaM. BucseaO. Laudiano-DrayM.P. WhiteheadK. MeekJ. FitzgeraldM. OlhedeS. JonesL. FabriziL. A developmental shift in habituation to pain in human neonates.Curr. Biol.202333813971406.e510.1016/j.cub.2023.02.07136931271
     [Google Scholar]
  121. ZhaoY. ZhuH. ChenX. LuoF. LiM. ZhouJ. ChenS. PanY. Pose-invariant and occlusion-robust neonatal facial pain assessment.Comput. Biol. Med.202316510746210.1016/j.compbiomed.2023.10746237716244
     [Google Scholar]
  122. Pillai RiddellR.R. BucseaO. ShiffI. ChowC. GennisH.G. BadovinacS. DiLorenzo-KlasM. RacineN.M. Ahola KohutS. LisiD. TurcotteK. StevensB. UmanL.S. Non-pharmacological management of infant and young child procedural pain.Cochrane Database Syst. Rev.202366CD00627537314064
     [Google Scholar]
  123. AllegaertK. TibboelD. van den AnkerJ. Narcotic-sparing approaches and the shift toward paracetamol in neonatal intensive care.Handb. Exp. Pharmacol.201926149150610.1007/164_2019_20730879201
     [Google Scholar]
  124. YilmazD. Yilmaz KurtF. The effect of foot reflexology on procedural pain before heel lancing in neonates.Arch. Pediatr.202128427828410.1016/j.arcped.2021.02.01533715931
     [Google Scholar]
  125. RomantsikO. CalevoM.G. NormanE. BruschettiniM. Clonidine for pain in non-ventilated infants.Cochrane Database Syst. Rev.202044CD01310432270873
     [Google Scholar]
  126. MaroniA. AubelleM.S. ChollatC. Fetal, preterm, and term neonate exposure to remifentanil: A systematic review of efficacy and safety.Paediatr. Drugs202325553755510.1007/s40272‑023‑00583‑w37541994
     [Google Scholar]
  127. BergR.B. LaarmanA.R.C. BloemL.T. DijkstraJ.A. VeldkampA.I. AllegaertK. SwartE.L. WeissenbruchM.M. Neonatal pain score after use of paracetamol: Is there a relationship with serum trough concentration at steady state in preterm and term neonates?.Int. J. Clin. Pharmacol. Ther.202361835436210.5414/CP20443137347121
     [Google Scholar]
  128. IvanicS. TongL.S. LairdA. MalhotraA. NatarajaR.M. LangC. PacilliM. The newborn infant parasympathetic evaluation (NIPE™) monitor predicts post-operative pain in children undergoing day-procedures: A prospective observational study.J. Pediatr. Surg.202358468468810.1016/j.jpedsurg.2022.12.00736646541
     [Google Scholar]
  129. PassarielloA. MontaldoP. PalmaM. CirilloM. Di GuidaC. EspositoS. CarusoM. PuglieseM. GilibertiP. Neonatal painful stimuli: Skin conductance algesimeter index to measure efficacy 24% of sucrose oral solution.J. Matern. Fetal Neonatal Med.202033213596360110.1080/14767058.2019.158069030786793
     [Google Scholar]
  130. RüdigerM. RozyckiH.J. Apgar score—It is time to avoid pain—Reply.JAMA Pediatr.2021175220710.1001/jamapediatrics.2020.256032926080
     [Google Scholar]
  131. GiordanoV. LuisterA. ReuterC. Czedik-EysenbergI. SingerD. SteyrlD. VettorazziE. DeindlP. Audio feature analysis for acoustic pain detection in term newborns.Neonatology2022119676076810.1159/00052620936116434
     [Google Scholar]
  132. TanjuO. Fatma YilmazK. Effect of acupressure on procedural pain before heel lancing in neonates.J. Tradit. Chin. Med.202141233133733825415
     [Google Scholar]
  133. Jimeno RuizS. Riaza GómezM. Cárdenas RebolloJ.M. López-EscobarA. Material and sedation-analgesia in the neonatal lumbar puncture procedure.An. Pediatr.202195424625210.1016/j.anpede.2020.07.023
     [Google Scholar]
  134. FitriS.Y.R. NasutionS.K. NurhidayahI. MaryamN.N.A. Massage therapy as a non-pharmacological analgesia for procedural pain in neonates: A scoping review.Complement. Ther. Med.20215910273510.1016/j.ctim.2021.10273533974990
     [Google Scholar]
  135. MinC. LingR. ChenM. XiaD. ChenR. LiX. Enriched environment rescues neonatal pain induced cognitive deficits and the impaired hippocampal synaptic plasticity later in life.Dev. Neurobiol.202282654556110.1002/dneu.2289835945168
     [Google Scholar]
  136. DiscenzaD.A. Pain in the NICU and beyond: A preemie parent perspective.Neonatal Netw.202241636836936446442
     [Google Scholar]
  137. ChenH. da Palma AfonsoE. ZhouJ. Newborns’ voice: We need pain management!Intensive Crit. Care Nurs.20216210297610.1016/j.iccn.2020.10297633257216
     [Google Scholar]
  138. McNamaraP.J. LeeS.S. StanfordA.H. BischoffA.R. RiosD.R. GiesingerR.E. Methodological rigor in both targeted neonatal echocardiography training and study design are essential to understanding the impact of ultrasound on neonatal pain.J. Neonatal Perinatal Med.20221517910.3233/NPM‑21089834957953
     [Google Scholar]
  139. WermkeK. SereschkN. MayV. SalingerV. SanchezM.R. Shehata-DielerW. WirbelauerJ. The vocalist in the crib: The flexibility of respiratory behaviour during crying in healthy neonates.J. Voice20213519410310.1016/j.jvoice.2019.07.00431350110
     [Google Scholar]
  140. McLeanM.A. ScotenO.C. ChauC.M.Y. SynnesA. MillerS.P. GrunauR.E. Association of neonatal pain-related stress and parent interaction with internalizing behaviors across 1.5, 3.0, 4.5, and 8.0 years in children born very preterm.JAMA Netw. Open2022510e223808810.1001/jamanetworkopen.2022.3808836269352
     [Google Scholar]
  141. AndayaE. Campo-EngelsteinL. Conceptualizing pain and personhood in the periviable period: Perspectives from reproductive health and neonatal intensive care unit clinicians.Soc. Sci. Med.202126911355810.1016/j.socscimed.2020.11355833298385
     [Google Scholar]
  142. SharmaN. ArahnaV.P. SaxenaS. AteefM. SamuelA.J. Scoping out the scope of scoping reviews in neonatal and pediatric pain management: A scoping review methodological framework.J. Pediatr. Surg.202157815991608105308
     [Google Scholar]
  143. BenoitB. NewmanA. Martin-MisenerR. LatimerM. Campbell-YeoM. The influence of breastfeeding on cortical and bio-behavioural indicators of procedural pain in newborns: Findings of a randomized controlled trial.Early Hum. Dev.202115410530810.1016/j.earlhumdev.2021.10530833513546
     [Google Scholar]
  144. AbushanabD. AbounahiaF.F. AlsoukhniO. AbdelaalM. Al-BadriyehD. Clinical and economic evaluation of the impact of midazolam on morphine therapy for pain relief in critically ill ventilated infants with respiratory distress syndrome.Paediatr. Drugs202123214315710.1007/s40272‑020‑00432‑033354750
     [Google Scholar]
  145. YuW.C. ChiangM.C. LinK.C. ChangC.C. LinK.H. ChenC.W. Effects of maternal voice on pain and mother–Infant bonding in premature infants in Taiwan: A randomized controlled trial.J. Pediatr. Nurs.202263e136e14210.1016/j.pedn.2021.09.02234602338
     [Google Scholar]
  146. CookK.M. De Asis-CruzJ. KimJ.H. BasuS.K. AndescavageN. MurnickJ. SpoehrE. LiggettM. du PlessisA.J. LimperopoulosC. Experience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits.BMC Med.202321143510.1186/s12916‑023‑03141‑w37957651
     [Google Scholar]
  147. PalomaaA.K. HuhtalaS. TuomikoskiA.M. PölkkiT. Effectiveness of technology-based interventions compared with other non-pharmacological interventions for relieving procedural pain in hospitalized neonates: A systematic review.JBI Evid. Synth.20232181549158110.11124/JBIES‑22‑0017937218335
     [Google Scholar]
  148. SudoY. Seki-NagasawaJ. KajikawaD. KuratsujiG. HagaM. ShokranehF. YamajiN. OtaE. NambaF. Effect of fentanyl for preterm infants on mechanical ventilation: A systematic review and meta-analysis.Neonatology2023120328729410.1159/00052944036990067
     [Google Scholar]
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Neonatal Pain Management: Is There An Endocrinal Response?
Endocr Metab Immune Disord Drug Targets 25, 835 (2025); https://doi.org/10.2174/0118715303325556241127080237
/content/journals/emiddt/10.2174/0118715303325556241127080237
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  • Article Type:     Review Article
Keyword(s): anesthetic drugs; acetaminophen; analgesic drugs; breast milk; endocrine; Neonate; non-nutritive sucking; opioids; sucrose

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