A Glucuronidation Pathway of Capecitabine Occurs in Rats but Not in Mice and Humans

F. Desmoulin; C. Claparols; D. Bon; G. Larrieu; R. Martino; M. Malet-Martino

doi:10.2174/187231207780363615

ISSN: 1872-3128
E-ISSN: 1874-0758

A Glucuronidation Pathway of Capecitabine Occurs in Rats but Not in Mice and Humans
Authors: F. Desmoulin¹, C. Claparols², D. Bon³, G. Larrieu⁴, R. Martino⁵ and M. Malet-Martino⁶
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¹ Groupe de RMN Biomedicale,LSPCMIB UMR - CNRS 5068, Bat. 2R1, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France. ² Groupe de RMN Biomedicale,LSPCMIB UMR - CNRS 5068, Bat. 2R1, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France. ³ Groupe de RMN Biomedicale,LSPCMIB UMR - CNRS 5068, Bat. 2R1, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France. ⁴ Groupe de RMN Biomedicale,LSPCMIB UMR - CNRS 5068, Bat. 2R1, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France. ⁵ Groupe de RMN Biomedicale,LSPCMIB UMR - CNRS 5068, Bat. 2R1, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France. ⁶ Groupe de RMN Biomedicale,LSPCMIB UMR - CNRS 5068, Bat. 2R1, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France.
Source: Drug Metabolism Letters, Volume 1, Issue 2, Apr 2007, p. 101 - 107
DOI: https://doi.org/10.2174/187231207780363615
- Available online: 01 Apr 2007

Abstract

Glucuronidation of 5'-DFCR, a metabolite of capecitabine, was confirmed in experimental models from rats whereas 5'-DFCR glucuronide was detected neither in bile or liver from mice nor in livermicrosomes from human. Metabolic interactions at the level of the glucuronidation pathway between CAP and other drugs are unlikely in patients.

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2007-04-01

2025-10-11

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Article Type: Research Article

Keyword(s): Capecitabine; cytidine deaminase; glucuronide; human; mice; rat

A Glucuronidation Pathway of Capecitabine Occurs in Rats but Not in Mice and Humans

Abstract

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