Assessment of Cryopreserved Hepatocytes as an Alternative to Fresh Hepatocytes forComparative InterspeciesMetabolism Studieswith Suitable Acceptance Criteria

Ziqiang (Zack) Cheng; Christine E. Herron; Gary Bowers; Mark de Serres

doi:10.2174/187231207780363624

ISSN: 1872-3128
E-ISSN: 1874-0758

Assessment of Cryopreserved Hepatocytes as an Alternative to Fresh Hepatocytes forComparative InterspeciesMetabolism Studieswith Suitable Acceptance Criteria
Authors: Ziqiang (Zack) Cheng¹, Christine E. Herron², Gary Bowers³ and Mark de Serres⁴
View Affiliations Hide Affiliations

¹ Department of World-wide Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA. ² Department of World-wide Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA. ³ Department of World-wide Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA. ⁴ Department of World-wide Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA.
Source: Drug Metabolism Letters, Volume 1, Issue 2, Apr 2007, p. 109 - 120
DOI: https://doi.org/10.2174/187231207780363624
- Available online: 01 Apr 2007

Abstract

Fresh hepatocytes have been the choice for interspecies comparative drug metabolism studies. Cryopreserved hepatocytes represent a readily available alternative when combined with acceptance limits based on the metabolic turnover of 7-ethoxycoumarin. Results for the ten NCEs examined show that the metabolites formed were strongly correlated in fresh and cryopreserved hepatocytes.

Article metrics loading...

/content/journals/dml/10.2174/187231207780363624

2007-04-01

2025-10-11

From This Site

/content/journals/dml/10.2174/187231207780363624

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/dml/10.2174/187231207780363624

Article Type: Research Article

Keyword(s): comparative metabolism; Cryopreserved hepatocytes; fresh hepatocytes; metabolite profiling; radiochemical flow detection; structural identification

Assessment of Cryopreserved Hepatocytes as an Alternative to Fresh Hepatocytes forComparative InterspeciesMetabolism Studieswith Suitable Acceptance Criteria

Abstract

From This Site

Most Read This Month