Involvement of Cytochromes P450 2D6, 2B6 and 2C19 in the Metabolism of (-)-Deprenyl and N-Methyl,N-propargylphenylethylamine

K. A. Rittenbach; G. B. Baker

doi:10.2174/187231207780363589

ISSN: 1872-3128
E-ISSN: 1874-0758

Involvement of Cytochromes P450 2D6, 2B6 and 2C19 in the Metabolism of (-)-Deprenyl and N-Methyl,N-propargylphenylethylamine
Authors: K. A. Rittenbach¹ and G. B. Baker²
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¹ Neurochemical Research Unit,Department of Psychiatry, 1E7 Mackenzie Centre, University of Alberta,Edmonton, Alberta, Canada, T6G 2R7. ² Neurochemical Research Unit,Department of Psychiatry, 1E7 Mackenzie Centre, University of Alberta,Edmonton, Alberta, Canada, T6G 2R7.
Source: Drug Metabolism Letters, Volume 1, Issue 2, Apr 2007, p. 97 - 100
DOI: https://doi.org/10.2174/187231207780363589
- Available online: 01 Apr 2007

Abstract

The metabolism of (-)-deprenyl (N-methyl,N-propargylamphetamine) and N-methyl,N-propargylphenylethylamine (MPPE), monoamine oxidase inhibitors with neuroprotective properties, was studied using human liver microsomes and cDNA-expressed cytochrome P450 (CYP) enzymes. The metabolic pathways of MPPE parallel those of (-)- deprenyl, but some marked differences were observed, particularly with regard to the contributions of CYP2B6 and CYP2D6.

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2007-04-01

2025-10-11

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Article Type: Research Article

Keyword(s): amphetamine; cDNA; CYP2B6; Metabolism; propargylamphetamine

Involvement of Cytochromes P450 2D6, 2B6 and 2C19 in the Metabolism of (-)-Deprenyl and N-Methyl,N-propargylphenylethylamine

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