Comparison of Paraben Stability in Human and Rat Skin

Heather M. Harville; Richard Voorman; Jeffery J. Prusakiewicz

doi:10.2174/187231207779814300

ISSN: 1872-3128
E-ISSN: 1874-0758

Comparison of Paraben Stability in Human and Rat Skin
Authors: Heather M. Harville¹, Richard Voorman² and Jeffery J. Prusakiewicz³
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¹ 2800 Plymouth Rd. 20/342S-D,Ann Arbor, MI 48105, USA. ² 2800 Plymouth Rd. 20/342S-D,Ann Arbor, MI 48105, USA. ³ 2800 Plymouth Rd. 20/342S-D,Ann Arbor, MI 48105, USA.
Source: Drug Metabolism Letters, Volume 1, Issue 1, Jan 2007, p. 17 - 21
DOI: https://doi.org/10.2174/187231207779814300
- Available online: 01 Jan 2007

Abstract

Parabens are widely used preservatives in topical products, and are estrogenic in numerous experimental models. The typical cutaneous metabolism model, rat skin, hydrolyzes parabens much faster than human skin. Chronic application and absorption of parabens, combined with low metabolism rates, may lead to prolonged estrogenic effects in the skin.

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2007-01-01

2025-10-22

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Article Type: Research Article

Keyword(s): epidermal drug metabolism; esterase; Paraben; skin

Comparison of Paraben Stability in Human and Rat Skin

Abstract

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