In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol

Thomas K. H. Chang; Jie Chen; Chia-Ting Yu

doi:10.2174/187231207779814337

ISSN: 1872-3128
E-ISSN: 1874-0758

In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol
Authors: Thomas K. H. Chang¹, Jie Chen² and Chia-Ting Yu³
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¹ Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver,BC, V6T 1Z3, Canada. ² Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver,BC, V6T 1Z3, Canada. ³ Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver,BC, V6T 1Z3, Canada.
Source: Drug Metabolism Letters, Volume 1, Issue 1, Jan 2007, p. 13 - 16
DOI: https://doi.org/10.2174/187231207779814337
- Available online: 01 Jan 2007

Abstract

Piceatannol and its parent compound, trans-resveratrol, decreased the in vitro catalytic activity of rat CYP1A1 and CYP1A2 by mixed inhibition. trans-Resveratrol was not a mechanism-based inactivator of rat CYP1A in vitro and the administration of this compound (50 mg/kg) to rats did not affect hepatic microsomal CYP1A-mediated enzyme activity.

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2007-01-01

2025-10-21

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Article Type: Research Article

Keyword(s): CYP1A1; CYP1A2; cytochrome P450; piceatannol; trans-resveratrol

In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol

Abstract

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