ABCB1, SLCO1B1 and UGT1A1 Gene Polymorphisms Are Associated with Toxicity Line Irinotecan

Katrin E. Rhodes; Wu Zhang; Dongyun Yang; Oliver A. Press; Michael Gordon; Daniel Vallbohmer; Anne M. Schultheis; Georg Lurje; Robert D. Ladner; William Fazzone; Heinz-Josef Lenz; Syma Iqbal

doi:10.2174/187231207779814328

ISSN: 1872-3128
E-ISSN: 1874-0758

ABCB1, SLCO1B1 and UGT1A1 Gene Polymorphisms Are Associated with Toxicity Line Irinotecan
Authors: Katrin E. Rhodes¹, Wu Zhang², Dongyun Yang³, Oliver A. Press⁴, Michael Gordon⁵, Daniel Vallbohmer⁶, Anne M. Schultheis⁷, Georg Lurje⁸, Robert D. Ladner⁹, William Fazzone¹⁰, Heinz-Josef Lenz¹¹ and Syma Iqbal¹²
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¹ Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA. ² Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA. ³ Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA. ⁴ Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA. ⁵ Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA. ⁶ Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA. ⁷ Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA. ⁸ Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA. ⁹ Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA. ¹⁰ Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA. ¹¹ Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA. ¹² Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA.
Source: Drug Metabolism Letters, Volume 1, Issue 1, Jan 2007, p. 23 - 30
DOI: https://doi.org/10.2174/187231207779814328
- Available online: 01 Jan 2007

Abstract

We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.

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2007-01-01

2025-10-22

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Article Type: Research Article

Keyword(s): colorectal cancer; irinotecan; Polymorphisms; toxicity

ABCB1, SLCO1B1 and UGT1A1 Gene Polymorphisms Are Associated with Toxicity Line Irinotecan

Abstract

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