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2000
Volume 25, Issue 23
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Introduction

2.5% of adults worldwide suffer from hyperthyroidism, which is associated with osteoporosis, heart disease, and increased mortality.

Aim

The current study evaluates the protective and therapeutic effect of Ovothiol A on Thyroxine-induced hyperthyroidism in rats.

Methods

Experimental animals were split into two categories: protective and curative. Each group was further separated into three subgroups (6 per group): control, hyperthyroidism (HT), and Ovothiol-A (250 mg/kg). Thyroxine hormone (600 mg/kg) is administered orally to rats to induce HT.

Results

Ovothiol-A supplementation resulted in significant decreases in organ weight index, T3, T3,T4, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, malondialdehyde, nitric oxide levels, and tumour necrosis factor-alpha while increasing in body weight, TSH, glutathione reduced, catalase, and glutathione-S-transferase levels. Histopathological investigation revealed significant thyroid and liver tissue improvements, significantly reducing collagen deposition.

Conclusion

Ovothiol-A exhibited protective and therapeutic effects against hyperthyroidism in rats. Ovothiol-A exhibits antithyroid activity by stimulating the antioxidant system, reducing inflammation, and restoring thyroid hormone levels.

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2025-12-22

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Ovothiol-A Exhibited Protective and Therapeutic Effect against Hyperthyroidism in Rats
Curr. Top. Med. Chem. 25, 2773 (2025); https://doi.org/10.2174/0115680266349656250318020702
/content/journals/ctmc/10.2174/0115680266349656250318020702
/content/journals/ctmc/10.2174/0115680266349656250318020702
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  • Article Type:     Research Article
Keyword(s): antioxidant system; histopathology; Hyperthyroidism; liver dysfunction; Ovothiol-A; oxidative stress

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