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2000
Volume 12, Issue 1
  • ISSN: 2215-0838
  • E-ISSN: 2215-0846
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Abstract

Urolithiasis, a prevalent and recurrent disorder, imposes a significant global health burden. Conventional treatments often fail to prevent recurrence, prompting interest in nutraceutical interventions. This review explores the therapeutic potential of herbal extracts, glycomacropeptides (GMP), and probiotics in preventing kidney stone formation. Herbal medicine inhibits calcium oxalate (CaOx) crystallization, modulates urinary biochemistry, and mitigates oxidative stress bioactive phytochemicals. Probiotics, particularly , , and species, regulate oxalate metabolism and enhance gut-kidney axis function, reducing urinary oxalate excretion. GMP, a bioactive milk-derived peptide, offers renoprotective effects by minimizing uremic toxin production, alkalinizing urine, and modulating gut microbiota. Integrating these nutraceuticals into urolithiasis management may reduce stone recurrence, improve renal function, and serve as viable adjuncts to conventional therapies. This review synthesizes recent clinical, , and findings, emphasizing their mechanisms, efficacy, and translational potential in nephrolithiasis prevention.

© 2026 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/ctm/10.2174/0122150838378147250818072318
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Effects of Herbal Extracts, Glycomacropeptides, and Probiotics on Urolithiasis Prevention: An Overview
Current Traditional Medicine 12, E22150838378147 (2026); https://doi.org/10.2174/0122150838378147250818072318
/content/journals/ctm/10.2174/0122150838378147250818072318
/content/journals/ctm/10.2174/0122150838378147250818072318
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  • Article Type:     Review Article
Keyword(s): antioxidants; glycomacropeptides; Herbal plants; kidney stone prevention; probiotics; urinary biochemistry

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