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2000
Volume 12, Issue 1
  • ISSN: 2215-0838
  • E-ISSN: 2215-0846
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Abstract

Background

Further investigation is required to deeply understand the role of traditional medicines in menopause and their safe and effective usage.

Objective

To determine the effects of roscoe (ZO) and (CL) supplementation on 17-β estradiol (ES) levels, quality of life, and body composition indices in postmenopausal women.

Methods

In this four-month randomized controlled trial, women were recruited from the Tabriz health centers between 2018 and 2019 and randomly allocated to one of four groups: ZO tablet 1000 mg and CL placebo, CL tablet 1000 mg and ZO placebo, ZO tablet 1000 mg and CL tablet 1000 mg, and ZO placebo and CL placebo.

Results

One hundred and fifteen women completed this study. ZO (mean change (MC) = 3.18 (95% CI: 0.55 to 5.81)) resulted in a greater increase in serum ES than placebo. ZO (MC= -1.26 (95% CI: -2.78 to -0.72)), CL (MC=-1.21 (95% CI: -2.79 to -0.53)) and ZO + CL (MC=-1.69 (95% CI: -2.48 to -0.85)) resulted in greater improvements in total quality of life score compared to placebo (MC=-0.51(95% CI: -0.04 to 1.32)). A significant group difference favoring the ZO group compared to the placebo was detected for the vasomotor symptoms (MC= -1.03 (95% CI: -2.57 to -0.97)). No significant adverse events were noted.

Discussion

Findings suggest ginger and turmeric alleviate menopausal symptoms and improve QoL, potentially via estrogenic, anti-inflammatory, and antioxidant actions. Inconsistent body composition results may be due to low bioavailability.

Conclusion

Ginger, turmeric, and their combination improved menopausal QoL, with ginger benefiting vasomotor symptoms.

Clinical Trial Registration No.

Registered in the Iranian clinical trial registry (IRCT20161022030424N3) on 2018-04-29.

© 2026 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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The Effect of Ginger (Zingiber Officinale Roscoe) and Turmeric (Curcuma Longa) Supplementation on 17-β Estradiol Level, Quality of Life and Body Composition in Postmenopausal Women: Secondary Outcomes of a Randomized, Placebo Controlled Trial
Current Traditional Medicine 12, E22150838341012 (2026); https://doi.org/10.2174/0122150838341012241006094648
/content/journals/ctm/10.2174/0122150838341012241006094648
/content/journals/ctm/10.2174/0122150838341012241006094648
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  • Article Type:     Research Article
Keyword(s): 17-β estradiol; body composition; ginger; menopause; quality of life; turmeric

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