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2000
Volume 11, Issue 5
  • ISSN: 2215-0838
  • E-ISSN: 2215-0846

Abstract

Objective

Burns can be physically and mentally painful, making them one of the worst experiences. In this study, hydroalcoholic extracts of and were investigated as treatments for second-degree burns in male Wistar rats.

Methods

To create the burn wounds, a circular metal tool with a diameter of 2 cm was used, followed by treatment with prepared ointments including (1%), (1%), plus (1%), and Adib derm ointment. The wound area was measured and the wound tissue was examined histopathologically on days 1, 7, 14, and 21 in each group. The ointments were applied every day for 21 days to determine the wound healing rate.

Results

The experiment showed that on the sixth and eleventh days, the groups treated with a combination of and , and alone, demonstrated significant reductions in wound area. According to histopathology, both alone and in combination with significantly improved the inflammatory condition, epithelialization process, fibroplasia, arrangement, and density of collagen fibers when compared to the other groups.

Conclusion

The study showed that extract, either on its own or in combination with extract, has significant healing and restorative effects on second-degree burn wounds in animal models.

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2024-05-17
2026-01-03

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References

  1. BahramsoltaniR. FarzaeiM.H. RahimiR. Medicinal plants and their natural components as future drugs for the treatment of burn wounds: An integrative review.Arch. Dermatol. Res.2014306760161710.1007/s00403‑014‑1474‑624895176
     [Google Scholar]
  2. MousaH.A. Burn and scald injuries.East. Mediterr. Health J.2005115-61099110916761681
     [Google Scholar]
  3. Niko BakhtZ. Investigation of causes and factors of burns in children. In: The first national congress on burns. Tehran, Iran: Iran University of Medical Sciences2002
     [Google Scholar]
  4. QuX. DiaoY. ZhangZ. WangS. JiaY. Evaluation of anti-bacterial and wound healing activity of the fruits of Amorpha fruticosa l.Afr. J. Tradit. Complement. Altern. Med.201310345846810.4314/ajtcam.v10i3.1224146475
     [Google Scholar]
  5. RubinB.B. RomaschinA. WalkerP.M. GuteD.C. KorthuisR.J. Mechanisms of postischemic injury in skeletal muscle: Intervention strategies.J. Appl. Physiol.199680236938710.1152/jappl.1996.80.2.3698929572
     [Google Scholar]
  6. VenkatachalamM.A. WeinbergJ.M. Mechanisms of cell injury in ATP-depleted proximal tubules. Role of glycine, calcium, and polyphosphoinositides.Nephrol. Dial. Transplant.19949415217800249
     [Google Scholar]
  7. BehailuB. TemesgenA. Ethnobotanical value of medicinal plant diversity in cheha district, guraghe zone, southern nations, nationalities and peoples (snnpr) of Ethiopia.J. Med. Plants Res.2017112844545410.5897/JMPR2017.6356
     [Google Scholar]
  8. JamzadZ. Thyme and savory of Iran.Publications of Iran Forests and Rangelands Research Institute2009691
     [Google Scholar]
  9. MoralesR. The history, botany and taxonomy of the genus thymus. Thyme: The Genus Thymus.LondonTaylor and Francis, Inc.2002143
     [Google Scholar]
  10. MozaffarianV. Identification of medicinal and aromatic plants of iran. Farhang moaser. Tehran2012
     [Google Scholar]
  11. FaragR.S. BadeiA.Z.M.A. HewediF.M. BarotyE.G.S.A. Antioxidant activity of some spice essential oils on linoleic acid oxidation in aqueous media.J. Am. Oil Chem. Soc.198966679279910.1007/BF02653670
     [Google Scholar]
  12. WykV.B.E. WinkM. Medicinal plants of the world: An illustrated scientific guide to important medicinal plants and their uses. Health Fitness.Timber Press2004480
     [Google Scholar]
  13. JamesT.K. RahmanA. DouglasJ.A. Control of weeds in five herb crops.N. Z. Plant Prot.19914410837
     [Google Scholar]
  14. AsghariJ. TouliC. MazaheritehraniM. Aghdasi, MComparison of the microwave-assisted hydrodistillation with the traditional hydrodistillation method in the extraction of essential oils from Ferulago angulate (Schelcht.) Boiss.European J. Med. Plants20122432433410.9734/EJMP/2012/1488
     [Google Scholar]
  15. MollaeiS. SedighiF. HabibiB. HazratiS. AsgharianP. Extraction of essential oils of Ferulago angulata with microwave-assisted hydrodistillation.J. Ethnopharmacol.20191374351
     [Google Scholar]
  16. NasabAH SajadiE SadeghiH NaderianM AbediA The survey of phytochemical of Ferulago angulate (schlecht). Yasooj, Iran: BoissNational congress of medicine herbal2012
     [Google Scholar]
  17. RezazadehS.H. YazdaniD. ShahnaziS. Chemical composition of essential oil of ferulago angulata boiss. inflorescence from west of iran.Faslnamah-i Giyahan-i Daruyi200374952
     [Google Scholar]
  18. BadalamentiN. IlardiV. RosselliS. BrunoM. The ethnobotany, phytochemistry and biological properties of genus Ferulago – A review.J. Ethnopharmacol.202127411405010.1016/j.jep.2021.11405033753144
     [Google Scholar]
  19. SodeifianG. AnsariK. BamoniriA. MirjaliliB.F. Study of chemical composition of the essential oil of ferulago angulata (schelcht) boiss from Iran using supercritical fluid exteraction and nano scale injection.Dig. J. Nanomater. Biostruct.201161161168
     [Google Scholar]
  20. ShahbaziY. ShavisiN. KaramiN. KakaeiS. Chemical composition and in vitro antibacterial activity of ferulago angulata (schlecht.) boiss essential oil.J. Essent. Oil-Bear. Plants2015211611
     [Google Scholar]
  21. FirooziF.H. RahaviM. HamedaniP.M. HadjiakhundiA. DelnavaziM.R. Essential oil analysis and isolation of coumarins and flavonol glycosides of ferulago angulata (schltdl.) boiss. fruits.Ulum-i Daruyi202027113914610.34172/PS.2020.49
     [Google Scholar]
  22. AkkolE.K. In vitro enzyme inhibitory activity of ten ferulago w. koch species growing in turkey.Braz. Arch. Biol. Technol.202265e22210207
     [Google Scholar]
  23. TutarU. HepokurC. MisirS. HepokurA. Iduman, f. antimicrobial, antioxidant, cytotoxic and wound healing effects of thymbra sintenisii extract.Indian J. Pharm. Sci.2018805868874
     [Google Scholar]
  24. BasileA. SorboS. SpadaroV. Antimicrobial and antioxidant activities of coumarins from the roots of Ferulago campestris (Apiaceae).Molecules200914393995210.3390/molecules1403093919255552
     [Google Scholar]
  25. BahmaniM. TaherikalaniM. KhaksarianM. SoroushS. AshrafiB. HeydariR. Phytochemical profiles and antibacterial activities of hydroalcoholic extracts of origanum vulgare and hypericum perforatum and carvacrol and hypericin as a promising anti-Staphylococcus aureus.Mini Rev. Med. Chem.2019191192393210.2174/138955751966619012112431730663566
     [Google Scholar]
  26. KarimiE. AbbasiS. AbbasiN. Thymol polymeric nanoparticle synthesis and its effects on the toxicity of high glucose on OEC cells: Involvement of growth factors and integrin-linked kinase.Drug Des. Devel. Ther.2019132513253210.2147/DDDT.S21445431440034
     [Google Scholar]
  27. MillerD.L. DouC. DongZ. RaghavendranK. The influence of dexmedetomidine on ultrasound-induced pulmonary capillary hemorrhage in rats.Ultrasound Med. Biol.201642496497010.1016/j.ultrasmedbio.2015.12.00426774471
     [Google Scholar]
  28. JarrahiM. VafaeiA.A. Effect of topical phenytoin cream on linear incisional wound healing in albino rats.Daru2004124156158
     [Google Scholar]
  29. TaranM. Ghasempou,r H., Shirinpour, E. Antimicrobial activity of essential oils of Ferulago angulata subsp. Carduchorun.Jundishapur J. Microbiol.2010311014
     [Google Scholar]
  30. ZareiiB SeyfiT MovahediR CheraghiJ EbrahimiS Anti bacterial effects of plant extracts of alcea digitata l., satureja bachtiarica l. and ferulago angulata L.J Babol Univ20141613137
     [Google Scholar]
  31. ÖNEL SE Aksu, t. the effect of thyme (thymbra spicata l. var. spicata) essential oil on the antioxidant potential and meat quality of Japanese quail fed in various stocking densities. atatürk university.J. Vet. Sci.2019142129136
     [Google Scholar]
  32. AmirghofranZ. HosseiniM.S. GolmoghaddamH. KalantarF. ShabaniM. Inhibition of nitric oxide production and proinflammatory cytokines by several medicinal plants.Iran. J. Immunol.20118315916921931202
     [Google Scholar]
  33. GovahiR. GhalamkariG. ToghyaniM. Effect of Ferulago angulata sub. carduchorum on total serum antioxidant activity and some of the humoral immune responses in broiler chicks.J. Herb. Med.201343119126
     [Google Scholar]
  34. AminM. KalantarE. SaeidM.N. AhsanB. Antibacterial effect and physicochemical properties of essential oil of zataria multiflora boiss.Asian Pac. J. Trop. Med.201036439442
     [Google Scholar]
  35. EsmaeiliA. MohabiN. Experimental and theoretical determination of the antioxidant properties of aromatic monoterpenes of thymol and 2, 5, 6- trifluorothymol.Int. J. Food Prop.201417511621166
     [Google Scholar]
  36. BlumenthalM. Herbal Medicine: Expanded Commission E Monographs.1st edUSAIntegrative Medicine Communications2000519
     [Google Scholar]
  37. GhashghaeF. JafariA. MoazamianE. Survey effect of peganum harmala, thymus daenensis, frulago angulata on woundinfection caused by pseudomonas aeruginosa exotoxin a-producing in laboratorymice.Iran. J. Med. Microbiol.20161018285
     [Google Scholar]
  38. SaǧdιçO. Sensitivity of four pathogenic bacteria to Turkish thyme and oregano hydrosols.Lebensm. Wiss. Technol.200336546747310.1016/S0023‑6438(03)00037‑9
     [Google Scholar]
  39. DarvishiM. Omrani nava, A.; Karimi, E.; Nouri, M.; Meigooni, S.S.; Hejripoor, S.Z. Human and animal bites.Caspian J. Environ. Sci.202321244545610.22124/cjes.2023.6539
     [Google Scholar]
  40. DastyarN. LysiukR. Identification of the most important medicinal plants used for wound healing: An ethnobotanical study of sistan and Baluchestan province, Southeastern Iran.J Biochem Phytomed202321161910.34172/jbp.2023.5
     [Google Scholar]
  41. ZangenehM.M. ZangenehA. EtemadiN. AghdaT.S.J. PourkamalzadehM. ZandS. The effect of nano silver particles of the aqueous extract of artemisia aucheri on the healing process of skin wounds in rats.Plant Biotechnol Persa2023511710.61186/pbp.5.1.1
     [Google Scholar]
  42. ShahmoradiM.K. NogoraniA.M. MansouriF. ZareiL. Combination of zinc nanoparticles with chitosan scaffolds increased cytokine genes on wound healing of infected rats with methicillin-resistant Staphylococcus aureus (MRSA).Adv. Life Sci.20231019398
     [Google Scholar]
  43. TahanA. JafariM. RazmjoueD. Relationship among some ecological factors and chemical composition of ajuga chamaecistus ging.Acta Ecol. Sin.2020404268276
     [Google Scholar]
  44. AidyA. KarimiE. GhaneialvarH. MohammadpourS. AbbasiN. Protective effect of Nectaroscordum tripedale extract and its bioactive component tetramethylpyrazine against acetaminophen-induced hepatotoxicity in rats.Advances in Traditional Medicine202020347147710.1007/s13596‑020‑00431‑z
     [Google Scholar]
  45. ChangaeeF. GoudarziM.A. GhobadiR. ParsaeiP. Antioxidant effects of methanolic extracts of anthemis susiana nabelek, alyssum campestre, and gundelia tournefortii.Caspian J. Environ. Sci.20231610.22124/cjes.2023.6714
     [Google Scholar]
  46. BrahmachariG. MandalL.C. RoyR. Lupeol, a pharmaceutically potent triterpenoid, from the ripe fruits of rauvolfia tetraphylla l.(Apocynaceae).J. Indian Chem. Soc.2011882303305
     [Google Scholar]
  47. MousaviS. VakiliS. ZalF. Quercetin potentiates the anti-osteoporotic effects of alendronate through modulation of autophagy and apoptosis mechanisms in ovariectomy-induced bone loss rat model.Mol. Biol. Rep.20235043693370310.1007/s11033‑023‑08311‑w36829081
     [Google Scholar]
  48. ShiZ. MahdavianY. MahdavianY. Cu immobilized on chitosan modified iron oxide magnetic nanoparticles: Preparation, characterization and investigation of its anti-lung cancer effects.Arab. J. Chem.2021148103224
     [Google Scholar]
  49. ZamaniA. Effects of natural carotenoid (carrot and red bell pepper) on growth performance, digestive enzymes and antioxidant enzymes in koi, Cyprinus rubrofuscus.Aqua Animals Nutr20239411310.22124/janb.2023.25813.1222
     [Google Scholar]
  50. MajhiS. Discovery, development and design of anthocyanins-inspired anticancer agents: A comprehensive review.Anticancer. Agents Med. Chem.202222193219323810.2174/1871520621666211015142310
     [Google Scholar]
  51. AbbasiN. AkhavanM.M. RoshandelR.N. ShafieiM. The effects of low and high concentrations of luteolin on cultured human endothelial cells under normal and glucotoxic conditions: Involvement of integrin-linked kinase and cyclooxygenase-2.Phytother. Res.20142891301130710.1002/ptr.512825201753
     [Google Scholar]
  52. EbrahimiY. JasimA.S. MohammedB.A. Salman A. N.; Jabbar, A.M., M. Hameed, N.; Goudarzi, M.A.; Parsaei, P. Determination of antioxidant properties of mentha longifolia, pistacia khinjuk and eucalyptus globulus.Caspian J. Environ. Sci.20221610.22124/cjes.2022.6065
     [Google Scholar]
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Healing Effect of Hydroalcoholic Extracts of Thymbra Spicata and Ferulago Angulata on Second-degree Burn Wounds in Rats
Current Traditional Medicine 11, E170524230040 (2025); https://doi.org/10.2174/0122150838301907240429101439
/content/journals/ctm/10.2174/0122150838301907240429101439
/content/journals/ctm/10.2174/0122150838301907240429101439
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  • Article Type:     Research Article
Keyword(s): body tissues; burns; Ferulago angulata; rat; Thymbra spicata; wound healing

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