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2000
Volume 11, Issue 2
  • ISSN: 2215-0838
  • E-ISSN: 2215-0846

Abstract

Ethnopharmacological relevance: belongs to the family Guttiferae. The plant widely grows in the hills and is planted in gardens in many parts of India. It is cultivated as an ornamental plant because of its graceful shape, pink to red hanging leaves and enormous wonderful, fragrant white blossoms. The current review summarizes different significant, fundamental and medicinal properties of this Indian therapeutic herb. It is known to be an evergreen tree 20-30 m in height. Along with its elaborate utilization, entire plant has different therapeutic values in the conventional system of drugs. The main aim of this review is to provide a brief overview of the pharmacological, phytochemical, pharmacognostic, ethanomedical and toxicological studies of A comprehensive review of the literature was conducted using multiple search sites such as PubMed, Google Scholar, Springer, and Science Direct, Scopus, Web of Science, SciFinder, . Other literary sources include Wikipedia, ethnobotanical books, and botanical journals. Numerous phytochemicals have been discovered and isolated from plant parts which include xanthones, terpenoids, sterol, β-amyrin, β-sitosterol, mesuaferrol, mesuaferrin-A, mesuaferrin B, caloxanthone C,1,8-dihydro-3-methoxy-6-methylanthraquinone, friedelin, fats, flavanoids and betulinic acid. All of the documented pharmacological activities, such as antioxidant and antibacterial activity, antiarthritic, anti-inflammatory, antivenom, antiulcerogenic, anticonvulsant, wound healing, depressant, analgesic are due to the presence of certain phytochemical substances. This review mainly targets the botanical aspects of along with their phytochemical constituents, ethnomedicinal use, different pharmacological activity, and future possibilities. is very important in the traditional Indian system. More research is needed to uncover important features of in medical practice.

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References

  1. KirtikarK.R. Indian Medicinal Plants1-42nd Allahbad, India1935274
     [Google Scholar]
  2. GontijoV.S. de SouzaT.C. RosaI.A. SoaresM.G. da SilvaM.A. VilegasW. ViegasC. dos SantosM.H. Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp.Food Chem.201213231230123510.1016/j.foodchem.2011.10.11029243605
     [Google Scholar]
  3. EeGCL LimCK Xanthones and triterpenoids from Mesua daphnifolia and Garcinia maingayi.Malaysian. J. Sci.200524183185
     [Google Scholar]
  4. LimT.K. Lepidium meyenii.Edible Medicinal and Non Medicinal PlantsSpringer Dordrecht2015980182810.1007/978‑94‑017‑9511‑1_30
     [Google Scholar]
  5. Anonymous. Ayurvedic Pharmacopoeia of India. Part 1, Vol 2.Govt. of India Ministry oh Health and Family Welfare, department of Ayurveda, Yoga-Naturopathy, Unani, Siddha and Homeopathy (AYUSH)1st New Delhi1999118119
     [Google Scholar]
  6. RatnamhinA. ElliottS. WangpakapattanawongP. Vegetative propagation of rare tree species for forest restoration.Chiang. Mai. J. Sci.2011382306310
     [Google Scholar]
  7. GargS. SharmaK. RanjanR. AttriP. MishraP. In vivo antioxidant activity and hepatoprotective effects of methanolic extract of Mesua ferrea linn.Int. J. Pharm. Tech. Res.20091416921696
     [Google Scholar]
  8. SaxenaA. DixitS. AggarwalS. SeenuV. PrashadR. BhushanS. TranikantiV. MisraM. SrivastavaA. An ayurvedic herbal compound to reduce toxicity to cancer chemotherapy: A randomized controlled trial.Indian J. Med. Paediatr. Oncol.2008292111810.4103/0971‑5851.51426
     [Google Scholar]
  9. AnandakumarA. Nagakesara : A comparative pharmacognosy.Anc. Sci. Life.198654263268
     [Google Scholar]
  10. SharmaA. SharmaS. RR. NN. ParasharB. Mesua ferrae linn:- A review of the Indian medical herb.Syst. Rev. Pharm.201681192310.5530/srp.2017.1.5
     [Google Scholar]
  11. AkshitaC. VijayB.V. PraveenD. Evaluation of phytochemical screening and antimicrobial efficacy of Mesua Ferrea and Piper cubeba fruit extracts against multidrug resistant bacteria.Pharmacophore.20201121520
     [Google Scholar]
  12. RoyS.K. KumariN. PahwaS. Nora efflux pump inhibitory activity of coumarins from mesua ferrea.Fitoterapia20139014015010.1016/j.fitote.2013.07.015
     [Google Scholar]
  13. TehSS EeGCL MahSH In vitro cytotoxic, antioxidant, and antimicrobial activities of mesua beccariana (Baill.) Kosterm., Mesua ferrea Linn., and mesua congestiflora extracts.Biomed Res Int.20132013
     [Google Scholar]
  14. TehS. EeG. MahS. LimY. AhmadZ. Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.Molecules20131821985199410.3390/molecules1802198523381024
     [Google Scholar]
  15. AdibA. YunosN.J.C. Anti-cancer, antimicrobial, and antioxidative potentials of Mesua ferrea L. and its phytochemical constituents: A review.Asian J Pharmacogn.201933519
     [Google Scholar]
  16. ChoudhuryS. AhmedR. BarthelA. LeclercqP.A. Volatile oils of Mesua ferrea (L.) from Assam, India.J. Essent. Oil Res.199810549750110.1080/10412905.1998.9700955
     [Google Scholar]
  17. RajuMS SrimannarayanaG PaNVS Structure of Mesuaferrone-B a new biflavanone from the stamens of Mesua ferrea Linn.Tetrah. Let.197617494509451210.1016/0040‑4039(76)80156‑6
     [Google Scholar]
  18. KumarKA A New cyclo hexadione from Mesua ferrea.Phytochemistry19882723252327
     [Google Scholar]
  19. ZhouF. 4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity.Med. Chem. Res.2022311221722181https://link.springer.com/article/10.1007/s00044-022-02962-3
     [Google Scholar]
  20. MahandruM.M. RavindranV.K. Surangin c, a coumarin from mammea longifolia.Phytochemistry198625255555610.1016/S0031‑9422(00)85529‑6
     [Google Scholar]
  21. NordinK. Volatile components of methanol extract from the flower of malaysian Musea Ferrea Linn.Orient. J. Chem.2004206972
     [Google Scholar]
  22. BalaK.R. SeshadriT.R. Isolation and synthesis of some coumarin components of Mesua ferrea seed oil.Phytochemistry19711051131113410.1016/S0031‑9422(00)89951‑3
     [Google Scholar]
  23. Abu SayeedM. Abbas AliM. SohelF.I. Astaq Mohal KhanG.R.M. Sarmina YeasminM. Physico-chemical characteristics of Mesua ferrea/ seed oil and nutritional composition of its seed and leaves/.Bull. Chem. Soc. Ethiop.200418215716610.4314/bcse.v18i2.61435
     [Google Scholar]
  24. Keawsa-ArdS. KongtaweelertS. Antioxidant, antibacterial, anticancer activities and chemical constituents of the essential oil from Mesua ferrea leaves.Chiang. Mai. J. Sci.2012393455463
     [Google Scholar]
  25. ZhangX. GaoR. LiuY. CongY. ZhangD. ZhangY. YangX. LuC. shenY. Anti-virulence activities of biflavonoids from Mesua ferrea L. flower.Drug Discov. Ther.201913422222710.5582/ddt.2019.0105331534074
     [Google Scholar]
  26. PaiB.R. RaoU.R. Constituent of mesua ferrea L.Bioac. Comp. Underut. Fru. Nuts.19401966277
     [Google Scholar]
  27. ColumbiaB. Chemical constituents of the heart wood of Mesua ferrea.Phytochemistry1968719651968
     [Google Scholar]
  28. WaliaS. Ferrxanthone, a 1,3,5,6-tetraoxygenated. 1984; 23(8): 18167
     [Google Scholar]
  29. LianEe GC. RahmaniM. Taufiq-YapYH. GoR. MahSH. Pyranoxanthones from mesua ferrea.Molecules201116756475654https://www.mdpi.com/1420-3049/16/7/5647
     [Google Scholar]
  30. BavinP.M.G. DewarM.J.S. Synthesis of the mononitrophenanthrenes.J. Chem. Soc.19554477447910.1039/jr9550004477
     [Google Scholar]
  31. ChaharM.K. Sanjaya KumarD.S. LokeshT. ManoharaK.P. In-vivo antioxidant and immunomodulatory activity of mesuol isolated from Mesua ferrea L. seed oil.Int. Immunopharmacol.201213438639110.1016/j.intimp.2012.05.00622634479
     [Google Scholar]
  32. PayáM. HalliwellB. HoultJ.R.S. Interactions of a series of coumarins with reactive oxygen species.Biochem. Pharmacol.199244220521410.1016/0006‑2952(92)90002‑Z1322662
     [Google Scholar]
  33. PayaM. GoodwinP.A. De Las HerasB. HoultJ.R.S. Superoxide scavenging activity in leukocytes and absence of cellular toxicity of a series of coumarins.Biochem. Pharmacol.199448344545110.1016/0006‑2952(94)90273‑98068031
     [Google Scholar]
  34. MakchuchitS. ItharatA. TewtrakulS. Antioxidant and nitric oxide inhibition activities of Thai medicinal plants.J. Med. Assoc. Thai.2010937S227S23521294419
     [Google Scholar]
  35. RajeshK.P. ManjunathaH. KrishnaV. Kumara SwamyB.E. Potential in vitro antioxidant and protective effects of Mesua ferrea Linn. bark extracts on induced oxidative damage.Ind. Crops Prod.20134718619810.1016/j.indcrop.2013.03.008
     [Google Scholar]
  36. Prasad DN. RaoB.G. RaoE.S. RaoT.M. Praneeth DV.S. Quantification of phytochemical constituents and in-vitro antioxidant activity of Mesua ferrea leaves.Asian Pac. J. Trop. Biomed.201222Suppl.S539S54210.1016/S2221‑1691(12)60269‑X
     [Google Scholar]
  37. ChakrabortyD. ArefinP. BhattacharjeeS.C. Biological activity of Mesua ferrea (Nageswar) seed extracts: An in vitro and in silico study.Informatics Med Unlocked202336101166Available from: https://linkinghub.elsevier.com/retrieve/pii/S2352914823000084
    [Google Scholar]
  38. AdewaleAI MirghaniMES MuyibiSA DaoudJI AbimbolaMM Anti-bacterial and cytotoxicity properties of the leaves extract of Nahar (Mesua ferrea) plant.Adv. Nat. Appl. Sci.201265 SPL.ISS. 4583587
     [Google Scholar]
  39. VerottaL LovaglioE VidariG 4-Alkyl- and 4-phenylcoumarins from Mesua ferrea as promising multidrug resistant antibacterials.Phytochemistry20046521 SPEC. ISS.28672879
     [Google Scholar]
  40. MazumderR. DastidarS.G. BasuS.P. MazumderA. SinghS.K. Antibacterial potentiality ofMesua ferrea Linn. flowers.Phytother. Res.2004181082482610.1002/ptr.157215551387
     [Google Scholar]
  41. ParekhJ. ChandaS. In vitro screening of antibacterial activity of aqueous and alcoholic extracts of various Indian plant species against selected pathogens from Enterobacteriaceae.Afr. J. Microbiol. Res.2007169299
     [Google Scholar]
  42. ParekhJ. ChandaS. In vitro antifungal activity of methanol extracts of some Indian medicinal plants against pathogenic yeast and moulds.Afr. J. Biotechnol.200872343494353
     [Google Scholar]
  43. PittetD. AllegranziB. SaxH. DharanS. Pessoa-SilvaC.L. DonaldsonL. BoyceJ.M. Evidence-based model for hand transmission during patient care and the role of improved practices.Lancet Infect. Dis.200661064165210.1016/S1473‑3099(06)70600‑417008173
     [Google Scholar]
  44. AdewaleA.I. MirghaniM.E.S. MuyibiS.A. DaoudJ.I. AbimbolaM.M. Disinfection studies of Nahar (Mesua ferrea) seed kernel oil using pour plate method.Afr. J. Biotechnol.201110811874918754
     [Google Scholar]
  45. AruldassC.A. MarimuthuM.M. RamanathanS. MansorS.M. MurugaiyahV. Effects of Mesua ferrea leaf and fruit extracts on growth and morphology of Staphylococcus aureus.Microsc. Microanal.201319125426010.1017/S143192761201378523332129
     [Google Scholar]
  46. JalalpureS.S. MandavkarY.D. KhalureP.R. ShindeG.S. ShelarP.A. ShahA.S. Antiarthritic activity of various extracts of Mesua ferrea Linn. seed.J. Ethnopharmacol.2011138370070410.1016/j.jep.2011.09.04221986230
     [Google Scholar]
  47. KamalutheenM. GopalakrishnanS. IsmailT.S. Anti-inflammatory and anti-arthritic activities of Merremia tridentata (L.) Hall. f.E-J. Chem.20096494394810.1155/2009/670617
     [Google Scholar]
  48. PatilK.R. PatilC.R. JadhavR.B. MahajanV.K. PatilP.R. GaikwadP.S. Anti-arthritic activity of bartogenic acid isolated from fruits of Barringtonia racemosa Roxb. (Lecythidaceae).Evid .based Compl. Altern. Med.20112011785245https://onlinelibrary.wiley.com/doi/full/10.1093/ecam/nep148
     [Google Scholar]
  49. GuptaA. In vitro anti-inflammatory activity of root aqueous extract of Mesua ferrea in human whole blood and peripheral blood mononuclear cells using flow cytometry.Int. J. Pharm.LIFE.Sci.20143903
     [Google Scholar]
  50. MurthuzaS. ManjunathaB.K. In vitro and in vivo evaluation of anti-inflammatory potency of Mesua ferrea, Saraca asoca, Viscum album & Anthocephalus cadamba in murine macrophages raw 264.7 cell lines and Wistar albino rats.Beni. Suef Univ. J. Basic Appl. Sci.20187471972310.1016/j.bjbas.2018.10.001
     [Google Scholar]
  51. UawonggulN. ChaveerachA. ThammasirirakS. ArkaravichienT. ChuachanC. DaduangS. Screening of plants acting against Heterometrus laoticus scorpion venom activity on fibroblast cell lysis.J. Ethnopharmacol.2006103220120710.1016/j.jep.2005.08.00316169172
     [Google Scholar]
  52. LimT.K. Edible medicinal and non medicinal plants 2015.10.1007/978‑94‑017‑9511‑1
     [Google Scholar]
  53. KastureV.S. ChopdeC.T. DeshmukhV.K. Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals.J. Ethnopharmacol.2000711-2657510.1016/S0378‑8741(99)00192‑010904147
     [Google Scholar]
  54. TiwariP.K. IrchhaiyaR. JainS.K. Evaluation of anticonvulsant activity of Mesua ferrea Linn. ethanolic flower extract.Int. J. Pharm. Life. Sci.20123315071509
     [Google Scholar]
  55. EsimoneC.O. NworuC.S. JacksonC.L. Cutaneous wound healing activity of a herbal ointment containing the leaf extract of Jatropha Curcas L. (Euphorbiaceae).Int. J. Appl. Res. Nat. Prod.20081414
     [Google Scholar]
  56. ChoudharyG. Wound healing activity of the ethanolic extract of.Int. J. Adv. Pharm.Biol. Chem.201213369371
     [Google Scholar]
  57. Shirsat-JohnP. SaldanhaT. KolheS. ZiyaurrahmanA.R. Antiamnesic effect of Mesua ferrea (L.) flowers on scopolamine-induced memory impairment and oxidative stress in rats.Adv. Trad. Med.20232311092110.1007/s13596‑022‑00654‑2
     [Google Scholar]
  58. AhmedM. DattaB.K. RoufA.S.S. JakupovicJ. Flavone and α-santalene derivatives from Polygonum flaccidum.Phytochemistry19913093155315610.1016/S0031‑9422(00)98279‑7
     [Google Scholar]
  59. WhittleB.A. The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics.Br. J. Pharmacol. Chemother.196422224625310.1111/j.1476‑5381.1964.tb02030.x14190460
     [Google Scholar]
  60. HassanT AliMS Analgesic activity of mesua ferrea linn.Dhak. Univ. J. Pharmac. Sci.2006517375
     [Google Scholar]
  61. GardenB. Effect of Mesua ferrea Linn.Ind. J. Exp. Biol.200543566568
     [Google Scholar]
  62. ChandaS. RakholiyaK. Combination therapy : Synergism between natural plant extracts and antibiotics against infectious diseases.Formatex.20112011520529
     [Google Scholar]
  63. TanakaR. MatsunagaS. Triterpene constituents from Euphorbia supina.Phytochemistry198827113579358410.1016/0031‑9422(88)80772‑6
     [Google Scholar]
  64. KaneriaM. ChandaS. Evaluation of antioxidant and antimicrobial capacity of Syzygium cumini L. Leaves extracted sequentially in different solvents.J. Food Biochem.201337216817610.1111/j.1745‑4514.2011.00614.x
     [Google Scholar]
  65. ChandaS. RakholiyaK. ParekhJ. Indian medicinal herb: Antimicrobial efficacy of Mesua ferrea L. seed extracted in different solvents against infection causing pathogenic strains.J. Acute Dis.20132427728110.1016/S2221‑6189(13)60143‑2
     [Google Scholar]
  66. JayanthiG. KamalrajS. KarthikeyanK. MuthumaryJ. Antimicrobial and antioxidant activity of the endophytic fungus Phomopsis sp. GJJM07 isolated from Mesua ferrea.Int. J. Curr. Sci.20111January8590
     [Google Scholar]
  67. ThirumagalN. JeyakumariA.P. Photocatalytic and antibacterial activities of AgNPs from Mesua Ferrea seed.SN Appl.Sci.2020212206410.1007/s42452‑020‑03650‑w
     [Google Scholar]
  68. RaveloA.G. RodriguezC. Dichloromethane as a solvent for lipid extraction and assessment of lipid classes and fatty acids from samples of different natures.J. Agric. Food Chem.2008564297430310.1021/jf073471e18505264
     [Google Scholar]
  69. StockertJ.C. Blázquez-CastroA. CañeteM. HorobinR.W. VillanuevaÁ. MTT assay for cell viability: Intracellular localization of the formazan product is in lipid droplets.Acta Histochem.2012114878579610.1016/j.acthis.2012.01.00622341561
     [Google Scholar]
  70. ZhaoH. OczosJ. JanowskiP. TrembeckaD. DobruckiJ. DarzynkiewiczZ. WlodkowicD. Rationale for the real-time and dynamic cell death assays using propidium iodide.Cytometry A201077A439940510.1002/cyto.a.2086720131407
     [Google Scholar]
  71. RajendranK. ReddyE.V. KhannaA. Anticancer effect of Mesua ferrea extracts on human pancreatic cancer cell line.Int J Life Sci Sci Res.201622198205
     [Google Scholar]
  72. ChenX. LiuZ. ZhongB. ZhuM. YaoH. ChenX. LuY. WangS. GuoY. Cytotoxic 4-phenylcoumarins from the flowering buds of Mesua ferrea.Nat. Prod. Res.202211010.1080/14786419.2022.214837836412548
     [Google Scholar]
  73. ZeitounM.A. HarrisW.B. HarrisW.D. Refining crude cottonseed oil dissolved in hexane.J. Am. Oil Chem. Soc.196239628628910.1007/BF02638118
     [Google Scholar]
  74. PrasadD.N. BasuS.P. SrivastavaA.K. Antispasmodic activity of the crude and purified oil of mesua ferrea seed.Anc. Sci. Life1999191-2747522556924
     [Google Scholar]
  75. NakyaiW. PabuprapapW. SroimeeW. AjavakomV. YingyongnarongkulB. SuksamrarnA. Anti-acne vulgaris potential of the ethanolic extract of mesua ferrea l. Flowers.Cosmetics20218410710.3390/cosmetics8040107
     [Google Scholar]
  76. OECDOECD guidelines for the testing of chemicals no. 423: acute oral toxicity-acute toxic class method.Paris, FranceOECD1996
     [Google Scholar]
  77. UdayabhanuJ. KaminideviS. ThangaveluT. A study on acute toxicity of methanolic extract of Mesua ferrea L. in Swiss albino mice.Asian J. Pharm. Clin. Res.2014736668
     [Google Scholar]
  78. ShirsatP. A RZ. KashikarR. AthavaleM. AthavaleT. TawareP. SaldanhaT. KolheS. TembhurneS. Subacute toxicity study of the ethanolic extract of Mesua ferrea (L.) flowers in rats.Drug Chem. Toxicol.20224541570157710.1080/01480545.2020.184713433207941
     [Google Scholar]
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  • Article Type:     Review Article
Keyword(s): ethnomedicinal uses; guttiferae; Mesua ferrea Linn; morphology; pharmacology; phytochemistry; toxicity

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