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image of Pharmacological Evaluation of the Combination Therapy of Novel Herbal Mixture in Polycystic Ovary Syndrome

Abstract

Introduction

An endocrine condition known as Poly-Cystic Ovarian Syndrome (PCOS) makes females of reproductive age more susceptible to insulin resistance, excessive levels of male hormones, and delayed ovulation. It is the main reason that stimulates infertility in females during their reproductive years. Thus, the objective of the present research is to determine whether oleo-gum resins derived from and could be beneficial in the treatment of PCOS using a female animal model (Wistar rats) that were administered 1 mg/ kg of letrozole for induction of the disease.

Methods

A combination therapy of and myrrh was used to study its effect on rat models administered letrozole (1 mg/kg), employed to induce PCOS. OECD Guidelines 407 and 423 were followed for toxicity studies.

Results

It was revealed that the polyherbal mixture is nontoxic and safe to use, according to the results. Furthermore, studies have investigated the potential of a combination of oleo-gum resins in the treatment of letrozole-induced PCOS using animal models. According to the information gathered, it was found that the prepared herbal mixture significantly affected the letrozole-induced PCOS rat models. Additionally, it seems to have potential benefits for PCOS-related hormonal and reproductive disorders.

Conclusion

The polyherbal mixture was considered safe for consumption at a dose concentration of under 2000 mg/ kg and can be used for an extended period. Additionally, the polyherbal mixture improved the outcome of the therapy of PCOS in rat models administered with letrozole (1 mg/ kg) employed to induce PCOS.

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2025-08-01
2025-11-07

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/content/journals/cpps/10.2174/0113892037368963250710184315
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Pharmacological Evaluation of the Combination Therapy of Novel Herbal Mixture in Polycystic Ovary Syndrome
Bentham Science Publishers ; https://doi.org/10.2174/0113892037368963250710184315
/content/journals/cpps/10.2174/0113892037368963250710184315
/content/journals/cpps/10.2174/0113892037368963250710184315
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  • Article Type:     Research Article
Keywords: Metabolic disorder ; Boswellia serrata ; Commiphora myrrh ; polycystic ovary syndrome ; infertility ; polycystic ovaries ; insulin resistance ; hormonal imbalance

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