s Metabolomics-based Approach to Pharmacotherapy Personalization: Advantages and Limitations

Background: A patient-focused approach to treatment, where individual characteristics provide the selection of optimal medication strategy for a particular patient, is the trend of current clinical therapy. An application of advanced “omics” technologies, which enable to detect the inter-individual variability in genomic, transcriptomic, proteomic, and metabolomic levels is a perspective way to achieve such personalization. Objective: In this review, the advantages of metabolomics-based approach as one of the most promising and perspective for individualization of pharmacotherapy are demonstrated. This approach provides a prediction of the inter-individual variability in drug response and allows monitoring effectiveness of drug treatment, correcting it in account of individual parameters of patients. Method: Comparative analysis of metabolomics-based approach and the current methods of drug treatment personalization are carried out. Results: Advantages and limitations of the metabolomics-based approach were identified and discussed. Conclusion: The perspective ways for solution of limitations of the metabolomics-based approach are considered.