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2000
Volume 31, Issue 38
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Plants are a source of a variety of compounds, such as vegetable oils, which are rich in fatty acids and possess skin-whitening properties. Considering the hyperpigmentation treatment challenges (lack of efficacy or aggressiveness), the constant search for new whitening substances is necessary. Given vegetable oils’ potential and application in dermatological and cosmetic products, we reviewed the scientific literature on vegetable oils with skin depigmenting activity. It was observed that a variety of species (, , , , , , , , , , , , , , , , , , , Taiwanese species Taichung selective No. 4 (TCS4) (Adlay bran), ) were evaluated regarding their skin whitening properties. All the studies demonstrated that the oils have skin whitening properties and that the oils’ activity is related to their composition. The harvesting period, as well as the extraction method, impact on the oils’ properties, hence in their activity. The use of vegetable oils can have advantages over an isolated compound as their components can have synergistic or adding effects. When conducting skin whitening experiments, it is recommended to employ multiple assays because vegetable oils can influence skin whitening through various mechanisms. Furthermore, more clinical trials should be encouraged, considering the potential of vegetable oils as skin-lightening ingredients. More innovative and effective formulations can be obtained using vegetable oils for skin whitening purposes.

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2025-11-01
2025-09-12

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References

  1. KunikO. SaribekovaD. LazzaraG. CavallaroG. Emulsions based on fatty acid from vegetable oils for cosmetics.Ind. Crops Prod.202218911577610.1016/j.indcrop.2022.115776
     [Google Scholar]
  2. FerrazC.A. PastorinhoM.R. Palmeira-de-OliveiraA. SousaA.C.A. Ecotoxicity of plant extracts and essential oils: A review.Environ. Pollut.2022292Pt B11831910.1016/j.envpol.2021.11831934656680
     [Google Scholar]
  3. HuerthK.A. HassanS. CallenderV.D. Therapeutic insights in melasma and hyperpigmentation management.J. Drugs Dermatol.201918871872931424704
     [Google Scholar]
  4. ContriR.V. FielL.A. PohlmannA.R. GuterresS.S. BeckR.C.R. Transport of substances and nanoparticles across the skin and in vitro models to evaluate skin permeation and/or penetration.Nanocosmetics and Nanomedicines: New Approaches for Skin Care. BeckR. GuterresS. PohlmannA. Berlin, HeidelbergSpringer Berlin Heidelberg201133610.1007/978‑3‑642‑19792‑5_1
     [Google Scholar]
  5. Ruiz RuizJ.C. Ortiz VazquezE.D.L.L. Segura CamposM.R. Encapsulation of vegetable oils as source of omega-3 fatty acids for enriched functional foods.Crit. Rev. Food Sci. Nutr.20175771423143410.1080/10408398.2014.100290626114760
     [Google Scholar]
  6. ZeitounH. Michael-JubeliR. El KhouryR. Baillet-GuffroyA. TfayliA. SalamehD. LteifR. Skin lightening effect of natural extracts coming from Senegal botanical biodiversity.Int. J. Dermatol.202059217818310.1111/ijd.1469931681985
     [Google Scholar]
  7. NdeD. FonchaA. Optimization methods for the extraction of vegetable oils: A review.Processes20208220910.3390/pr8020209
     [Google Scholar]
  8. ParnsamutN. KanlayavattanakulM. LourithN. Development and efficacy assessments of tea seed oil makeup remover.Ann. Pharm. Fr.201775318919510.1016/j.pharma.2016.11.00127988044
     [Google Scholar]
  9. AtharM. NasirS.M. Taxonomic perspective of plant species yielding vegetable oils used in cosmetics and skin care products.Afr. J. Biotechnol.20054136-44
     [Google Scholar]
  10. ParvezS. KangM. ChungH.S. ChoC. HongM.C. ShinM.K. BaeH. Survey and mechanism of skin depigmenting and lightening agents.Phytother. Res.2006201192193410.1002/ptr.195416841367
     [Google Scholar]
  11. HushchaY. BloI. Oton-GonzalezL. MauroG.D. MartiniF. TognonM. MatteiM.D. microRNAs in the regulation of melanogenesis.Int. J. Mol. Sci.20212211610410.3390/ijms2211610434198907
     [Google Scholar]
  12. LinJ.Y. FisherD.E. Melanocyte biology and skin pigmentation.Nature2007445713084385010.1038/nature0566017314970
     [Google Scholar]
  13. QianW. LiuW. ZhuD. CaoY. TangA. GongG. SuH. Natural skin-whitening compounds for the treatment of melanogenesis (Review).Exp. Ther. Med.202020117318510.3892/etm.2020.868732509007
     [Google Scholar]
  14. MasakiH. Role of antioxidants in the skin: Anti-aging effects.J. Dermatol. Sci.2010582859010.1016/j.jdermsci.2010.03.00320399614
     [Google Scholar]
  15. LevyC. KhaledM. FisherD.E. MITF: Master regulator of melanocyte development and melanoma oncogene.Trends Mol. Med.200612940641410.1016/j.molmed.2006.07.00816899407
     [Google Scholar]
  16. GuJ. ZhangX. SongB. ZhouD. NiuY. ChengG. ZhengY. WangY. Chemical composition of tobacco seed oils and their antioxidant, anti-inflammatory, and whitening activities.Molecules20222723851610.3390/molecules27238516
     [Google Scholar]
  17. VillarealM.O. KumeS. BourhimT. BakhtaouiF.Z. KashiwagiK. HanJ. GadhiC. IsodaH. Activation of MITF by argan oil leads to the inhibition of the tyrosinase and dopachrome tautomerase expressions in B16 murine melanoma cells.Evid. Based Complement. Alternat. Med.201320131910.1155/2013/34010723935660
     [Google Scholar]
  18. PrommabanA. KuanchoomR. SeepuanN. ChaiyanaW. Evaluation of fatty acid compositions, antioxidant, and pharmacological activities of pumpkin (Cucurbita moschata) seed oil from aqueous enzymatic extraction.Plants2021108158210.3390/plants1008158234451628
     [Google Scholar]
  19. SabaE. KimS.H. LeeY.Y. KimH.K. RohS.S. KwakY.S. ParkC.K. KimS.D. RheeM.H. Anti-melanogenic effects of korean red ginseng oil in an ultraviolet B-induced hairless mouse model.Molecules20202520475510.3390/molecules2520475533081281
     [Google Scholar]
  20. TingY. HuY.T. HuJ.Y. ChangW.C. HuangQ. HsiehS.C. Nanoemulsified adlay bran oil reduces tyrosinase activity and melanin synthesis in B16F10 cells and zebrafish.Food Sci. Nutr.20197103216322310.1002/fsn3.117631660135
     [Google Scholar]
  21. ShinJ.A. SunM. JeongJ.M. Borage oil treated with immobilized lipase inhibits melanogenesis.Lipids202055664965910.1002/lipd.1226633128473
     [Google Scholar]
  22. KooJ.H. LeeI. YunS.K. KimH.U. ParkB.H. ParkJ.W. Saponified evening primrose oil reduces melanogenesis in B16 melanoma cells and reduces UV-induced skin pigmentation in humans.Lipids201045540140710.1007/s11745‑010‑3405‑420352496
     [Google Scholar]
  23. QuilesJ. CabreraM. JonesJ. TsapekosM. CaturlaN. In vitro determination of the skin anti-aging potential of four-component plant-based ingredient.Molecules20222722810110.3390/molecules2722810136432202
     [Google Scholar]
  24. ZoioP. VenturaS. LeiteM. OlivaA. Pigmented full-thickness human skin model based on a fibroblast-derived matrix for long-term studies.Tissue Eng. Part C Methods202127743344310.1089/ten.tec.2021.006934148380
     [Google Scholar]
  25. Regulation (EC) No 1223/2009 of The European Parliament and of the council of 30 November 2009 on Cosmetic Products.OJEU.200939659209
     [Google Scholar]
  26. MohammedG.F. Al-DhubaibiM.S. MohamedM.L. Genital whitening with topical Cyperus rotundus oil enhances sexuality and quality of life.J. Cosmet. Dermatol.202221104490450210.1111/jocd.1491835290702
     [Google Scholar]
  27. ZaidA.N. Al RamahiR. Depigmentation and anti-aging treatment by natural molecules.Curr. Pharm. Des.201925202292231210.2174/138161282566619070315373031269882
     [Google Scholar]
  28. KhavkinJ. EllisD.A.F. Aging skin: Histology, physiology, and pathology.Facial Plast. Surg. Clin. North Am.201119222923410.1016/j.fsc.2011.04.00321763983
     [Google Scholar]
  29. ZillesJ.C. DuarteL.P. RuaroT.C. ZimmerA.R. Kulkamp-GuerreiroI.C. ContriR.V. Nanoemulsion containing kojic dipalmitate and rosehip oil: A promising formulation to treat melasma.Pharmaceutics202315246810.3390/pharmaceutics1502046836839792
     [Google Scholar]
  30. LaneM.E. Skin penetration enhancers.Int. J. Pharm.20134471-2122110.1016/j.ijpharm.2013.02.04023462366
     [Google Scholar]
  31. PhataleV. VaipheiK.K. JhaS. PatilD. AgrawalM. AlexanderA. Overcoming skin barriers through advanced transdermal drug delivery approaches.J. Control. Release202235136138010.1016/j.jconrel.2022.09.02536169040
     [Google Scholar]
  32. KrambeckK. SilvaV. SilvaR. FernandesC. CagideF. BorgesF. SantosD. Otero-EspinarF. LoboJ.M.S. AmaralM.H. Design and characterization of nanostructured lipid carriers (NLC) and nanostructured lipid carrier-based hydrogels containing passiflora edulis seeds oil.Int. J. Pharm.202160012044410.1016/j.ijpharm.2021.12044433713760
     [Google Scholar]
  33. SaeediM. EslamifarM. KhezriK. Kojic acid applications in cosmetic and pharmaceutical preparations.Biomed. Pharmacother.201911058259310.1016/j.biopha.2018.12.00630537675
     [Google Scholar]
  34. TeixeiraR.S. RochaP.R. PoloniniH.C. BrandãoM.A.F. ChavesM.G.A.M. RaposoN.R.B. Mushroom tyrosinase inhibitory activity and major fatty acid constituents of Amazonian native flora oils.Braz. J. Pharm. Sci.201248339940410.1590/S1984‑82502012000300006
     [Google Scholar]
  35. AndoH. WatabeH. ValenciaJ.C. YasumotoK. FurumuraM. FunasakaY. OkaM. IchihashiM. HearingV.J. Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: A new aspect of ubiquitin-proteasome function.J. Biol. Chem.200427915154271543310.1074/jbc.M31370120014739285
     [Google Scholar]
  36. RabrenovićB.B. DimićE.B. NovakovićM.M. TeševićV.V. BasićZ.N. The most important bioactive components of cold pressed oil from different pumpkin (Cucurbita pepo L.) seeds.Lebensm. Wiss. Technol.201455252152710.1016/j.lwt.2013.10.019
     [Google Scholar]
  37. JuhaimiF.A. GhafoorK. UsluN. Mohamed AhmedI.A. BabikerE.E. ÖzcanM.M. FadimuG.J. The effect of harvest times on bioactive properties and fatty acid compositions of prickly pear (Opuntia ficus-barbarica A. Berger) fruits.Food Chem.202030312538710.1016/j.foodchem.2019.12538731454759
     [Google Scholar]
  38. LinY.H. NienC.J. ChenL.G. LeeS.Y. ChangW.J. PanY.H. HsiehS.C. HuangH.M. Sapindus mukorossi seed oil changes tyrosinase activity of α-MSH-induced B16F10 cells via the antimelanogenesic effect of eicosenoic acid.Nat. Prod. Commun.202015111934578X2097229510.1177/1934578X20972295
     [Google Scholar]
  39. ChaikulP. LourithN. KanlayavattanakulM. Antimelanogenesis and cellular antioxidant activities of rubber (Hevea brasiliensis) seed oil for cosmetics.Ind. Crops Prod.2017108566210.1016/j.indcrop.2017.06.009
     [Google Scholar]
  40. ChaikulP. SripisutT. ChanpiromS. SathirachawanK. DitthawutthikulN. Melanogenesis inhibitory and antioxidant effects of Camellia oleifera seed oil.Adv. Pharm. Bull.20177347347710.15171/apb.2017.05729071231
     [Google Scholar]
  41. SuzukiS. FujisawaH. AbeJ. KimuraK. Anti-melanogenesis activity of supercritical carbon dioxide extract from Perilla frutescens seeds.Adv. Biol. Chem.2023131425510.4236/abc.2023.131004
     [Google Scholar]
  42. IshiiT. ShimizuT. ImaiM. HealyJ. RouzardK. TamuraM. FitzgeraldC. Arctigenin-enriched burdock seed oil (ABSO): A new skin brightening botanical extract.Cosmetics20231011010.3390/cosmetics10010010
     [Google Scholar]
  43. CuiH.X. DuanF.F. JiaS.S. ChengF.R. YuanK. Antioxidant and tyrosinase inhibitory activities of seed oils from Torreya grandis Fort. ex Lindl.BioMed Res. Int.2018201811010.1155/2018/531432030320135
     [Google Scholar]
  44. KothapalliL. DhakaneT. BhosaleK. ThomasA. Seed oils as tyrosinase inhibitors for the treatment of hyperpigmentation.Curr. Enzym. Inhib.202420212413110.2174/0115734080257150231017094342
     [Google Scholar]
  45. AthikomkulchaiS. TunitP. TadtongS. JantrawutP. SommanoS.R. ChittasuphoC. Moringa oleifera seed oil formulation physical stability and chemical constituents for enhancing skin hydration and antioxidant activity.Cosmetics202081210.3390/cosmetics8010002
     [Google Scholar]
  46. SilvaC.C. BenatiR.B. MassaroT.N.C. PereiraK.C. GasparL.R. MarcatoP.D. Antioxidant and anti-tyrosinase activities of quercetin-loaded olive oil nanoemulsion as potential formulation for skin hyperpigmentation.J. Dispers. Sci. Technol.202344142628263810.1080/01932691.2022.2116715
     [Google Scholar]
  47. CaoL. LiX. ZhaoJ. DuQ. DunJ. Skin pigmentation improvement with resveratrol microemulsion gel using polyoxyethylene hydrogenated castor oil.Drug Dev. Ind. Pharm.202349220721610.1080/03639045.2023.219550836971611
     [Google Scholar]
  48. Domínguez-OlivaA. Hernández-ÁvalosI. Martínez-BurnesJ. Olmos-HernándezA. Verduzco-MendozaA. Mota-RojasD. The importance of animal models in biomedical research: Current insights and applications.Animals2023137122310.3390/ani1307122337048478
     [Google Scholar]
  49. CortegianiA. AbsalomA.R. Importance of proper conduct of clinical trials.Br. J. Anaesth.2021126235435610.1016/j.bja.2020.09.03033121749
     [Google Scholar]
  50. ParviziM.M. SakiN. SamimiS. RadanferR. ShahriziM.M. ZarshenasM.M. Efficacy of castor oil cream in treating infraorbital hyperpigmentation: An exploratory single-arm clinical trial.J. Cosmet. Dermatol.202423391191710.1111/jocd.1605637927123
     [Google Scholar]
  51. ShahS. ChewS.K. Efficacy and safety of topical depigmenting agent in healthy human fair skin female volunteers: A single-arm study.J. Cosmet. Dermatol.201817583083910.1111/jocd.1243529193788
     [Google Scholar]
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Vegetable Oils in Skin Whitening - A Narrative Review
Curr. Pharm. Des. 31, 3029 (2025); https://doi.org/10.2174/0113816128361413250107114203
/content/journals/cpd/10.2174/0113816128361413250107114203
/content/journals/cpd/10.2174/0113816128361413250107114203
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  • Article Type:     Review Article
Keyword(s): chemical analysis; depigmentation; formulation; skin barrier; skin whitening; Vegetable oils

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