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2000
Volume 31, Issue 24
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

The human skin, being the largest organ, provides defense against bacteria, toxins, and ultraviolet radiation. The skin may experience changes like dryness, photodamage, oxidative damage, and inflammation. This review explores sources of fatty acids and how they can prevent skin damage, with the goal of determining their potential for preventing skin aging. The role and significance of various mechanistic pathways and molecular targets involved in skin aging are highlighted. By using current research findings, this review contributes to a comprehensive understanding of how fatty acids may serve as a proactive approach to promoting youthful skin and mitigating the signs of skin aging. In addition to treating specific skin conditions, nutraceuticals offer immense potential to minimize, postpone, or prevent premature skin aging. The substances that are most frequently employed include carotenoids, polyunsaturated fatty acids, plant polyphenols, bioactive peptides, oligosaccharides, and vitamins. Numerous human trials have demonstrated the impact of supplementing with these items on indicators of aging. The most pertinent clinical and non-clinical investigations are assessed in this review. Based on the comprehensive understanding of the significant role of fatty acids in addressing skin aging, this review may open doors and offer avenues for future explorations.

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2025-10-12

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/content/journals/cpd/10.2174/0113816128357677250116115754
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Skin Aging: Insights into the Role of Fatty Acids
Curr. Pharm. Des. 31, 1912 (2025); https://doi.org/10.2174/0113816128357677250116115754
/content/journals/cpd/10.2174/0113816128357677250116115754
/content/journals/cpd/10.2174/0113816128357677250116115754
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  • Article Type:     Review Article
Keyword(s): fatty acids; mechanistic pathways; MUFA; oligosaccharides; PUFA; Ultra violet radiation

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