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2000
Volume 31, Issue 23
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Introduction

The objective of the present study was to improve the anti-inflammatory and antibacterial activities of mastic gum resin (MGR). MGR was loaded into a phospholipid nanocarrier with or without partially hydrolyzed ginsenoside, followed by dispersion into distilled water.

Methods

The phospholipid nanocarrier dispersion showed significantly enhanced release, porcine skin/intestine permeation, and retention. When the ratio of the MGR partially hydrogenated ginsenoside reached 1:1 in the nanocarrier composition, the release increased 54.8-fold compared to the MGR powder suspended in the release media.

Results

Permeation of the nanocarrier dispersion through the porcine skin and intestine increased 160-fold and 42-fold, respectively, compared to permeation of the MGR powder suspension. Furthermore, the nanocarrier dispersion reduced NO production and iNOS mRNA expression in the LPS-stimulated RAW264.7 cells. MIC and MBC of the nanocarrier dispersion against were 4.11 ± 1.17 and 8.22 ± 2.35 µg/mL, respectively.

Conclusion

In conclusion, the anti-inflammatory and antibacterial activities of MGR were remarkably enhanced when the MGR was loaded into the nanocarrier with partially hydrolyzed ginsenoside.

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2025-09-02

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Fabrication of Mastic Gum Resin Tethered Phospholipid Nanocarriers for the Evaluation and Enhancement of Anti-inflammatory and Anti-bacterial Effects
Curr. Pharm. Des. 31, 1866 (2025); https://doi.org/10.2174/0113816128353794241225083428
/content/journals/cpd/10.2174/0113816128353794241225083428
/content/journals/cpd/10.2174/0113816128353794241225083428
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  • Article Type:     Research Article
Keyword(s): anti-bacterial effects; Anti-inflammatory effects; ginsenoside; lipid nanocarrier; mastic gum resin; nanocarrier

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