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2000
Volume 31, Issue 40
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Background

Radiation therapy is a crucial method used to treat various tumors, but it can lead to radiation pneumonitis. Shashen Maidong Decoction (SMD) is clinically used to treat radiation pneumonitis, but the exact mechanism remains unclear.

Methods

Herbal components and targets of SMD were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), the Encyclopedia of Traditional Chinese Medicine (ETCM), and Swiss Target Prediction platforms. Moreover, disease-related targets were retrieved from the GeneCards database. A Protein-protein Interaction (PPI) network was constructed using the STRING database and analyzed using the Cytoscape software. In addition, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using the DAVID database. Subsequently, the disease-active component-target network and drug-pathway-target network were constructed using Cytoscape. The molecular docking results were validated and visualized using Auto Dock and PyMOL software.

Results

In this study, 115 conserved active ingredients, 316 drug targets, and 355 radiation pneumonitis targets were identified. Among these, 75 targets were identified as intersecting targets. GO enrichment analysis revealed 494 biological processes, 36 cell components, and 59 molecular functions. KEGG analysis uncovered 118 signaling pathways, including the IL17 signaling pathway, TNF signaling pathway, HIF-1 signaling pathway, . The molecular docking results showed the core active ingredients of SMD, including quercetin, kaempferol, beta-carotene, and naringenin, to have strong binding ability with the core targets.

Conclusion

This study preliminarily confirmed that SMD may act on the TNF, IL17, and HIF-1 signaling pathways to exert its therapeutic effects on radiation pneumonitis by regulating the expression of inflammatory factors.

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Mechanism of Shashen Maidong Decoction in the Treatment of Radiation Pneumonitis Based on Network Pharmacology and Molecular Docking
Curr. Pharm. Des. 31, 3219 (2025); https://doi.org/10.2174/0113816128346708241223110504
/content/journals/cpd/10.2174/0113816128346708241223110504
/content/journals/cpd/10.2174/0113816128346708241223110504
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  • Article Type:     Research Article
Keyword(s): molecular docking; network pharmacology; radiation pneumonitis; radiation therapy; Shashen Maidong Decoction; signaling pathways

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