Skip to content
2000
Volume 31, Issue 30
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Skin ageing is influenced by intrinsic factors such as genetics and hormones, as well as extrinsic factors like environmental exposure, ultraviolet (UV) radiation, and diet. These factors lead to biochemical, biological, and structural changes in the skin. Plant-derived compounds with antioxidant and anti-inflammatory properties have emerged as potential anti-ageing agents. This comprehensive review, spanning data from 1997 to 2024, explores the role of nutraceuticals in skin anti-ageing. The research data were drawn from Google, PubMed, PubMed Central, Scopus, and various journal databases, including ScienceDirect, Springer, and Taylor & Francis. This review specifically examines plant-derived polyphenols, carotenoids, and other bioactive compounds, analysing their mechanisms through signalling pathways and cellular processes, using data from , , and clinical studies. Polyphenols like quercetin, curcumin, and epigallocatechin gallate (EGCG) have antioxidant and anti-inflammatory properties, helping to reduce oxidative stress, inflammation, UV-induced collagen degradation, and inflammatory cytokines. Notably, curcumin enhances collagen production and decreases the number of senescent cells. Carotenoids such as β-carotene, lutein, zeaxanthin, and lycopene protect against UV damage, and lycopene-rich tomato paste was specifically noted for its ability to reduce erythema and DNA damage. Additionally, compounds like resveratrol, fisetin, and wogonin exert protective effects against oxidative stress and inflammation, with resveratrol improving collagen synthesis and reducing the appearance of wrinkles. These plant-derived compounds can effectively combat skin ageing through various mechanisms, including the inhibition of oxidative stress, inflammation, and extracellular matrix degradation. They present a natural and sustainable approach to skincare in accord with the growing trend of conscious consumption. Future research should focus on understanding the long-term effects and determining the optimal dosage for clinical applications, highlighting the potential of integrating plant-based nutraceuticals into skincare regimens.

Loading

Article metrics loading...

/content/journals/cpd/10.2174/0113816128336661250218080928
2025-03-03
2025-10-15
Loading full text...

Full text loading...

References

  1. FarageM.A. MillerK.W. ElsnerP. MaibachH.I. Characteristics of the aging skin.Adv. Wound Care20132151010.1089/wound.2011.035624527317
    [Google Scholar]
  2. ShahS.A. OakesR.S. JewellC.M. Advancing immunotherapy using biomaterials to control tissue, cellular, and molecular level immune signaling in skin.Adv. Drug Deliv. Rev.202420911531510.1016/j.addr.2024.11531538670230
    [Google Scholar]
  3. PowellJ. Skin physiology.Women’s Heal. Medic.20063313013310.1383/wohm.2006.3.3.130
    [Google Scholar]
  4. ShinS.H. LeeY.H. RhoN.K. ParkK.Y. Skin aging from mechanisms to interventions: focusing on dermal aging.Front. Physiol.202314119527210.3389/fphys.2023.119527237234413
    [Google Scholar]
  5. ZhangS. DuanE. Fighting against Skin Aging.Cell Transplant.201827572973810.1177/096368971772575529692196
    [Google Scholar]
  6. SilvaS.A.M.E. Michniak-KohnB. LeonardiG.R. An overview about oxidation in clinical practice of skin ageing.An. Bras. Dermatol.201792336737410.1590/abd1806‑4841.2017548129186250
    [Google Scholar]
  7. FarageM.A. MillerK.W. BerardescaE. MaibachH.I. Psychological and Social Implications of Ageing Skin: Normal Ageing and the Effects of Cutaneous Disease.Textbook of Ageing Skin. FarageM.A. MillerK.W. MaibachH.I. Berlin, Heidelberg: Springer Berlin Heidelberg201511410.1007/978‑3‑642‑27814‑3_89‑2
    [Google Scholar]
  8. ShomeD. VaderaS. KhareS. RamM.S. AyyarA. KapoorR. DesaiN. Aging and the indian face: an analytical study of aging in the asian indian face.Plast. Reconstr. Surg. Glob. Open202083e258010.1097/GOX.000000000000258032537318
    [Google Scholar]
  9. GancevicieneR. LiakouA.I. TheodoridisA. MakrantonakiE. ZouboulisC.C. Skin anti-aging strategies.Dermatoendocrinol20124330831910.4161/derm.2280423467476
    [Google Scholar]
  10. MedoroA DavinelliS CollettiA Nutraceuticals as modulators of immune function: A review of potential therapeutic effects.Prev. Nutr. Food Sci.20233828910710.3746/pnf.2023.28.2.8937416796
    [Google Scholar]
  11. BeriK. Breathing to younger skin: ‘reversing the molecular mechanism of skin aging with yoga’.Future Sci. OA201622FSO12210.4155/fsoa‑2016‑001528031969
    [Google Scholar]
  12. HalagaliP InamdarA SinghJ Phytochemicals, herbal extracts, and dietary supplements for metabolic disease management.Endocr. Metab. Immune. Disord. Drug. Targets.2024122271072210.2174/011871530328791124040905571038676520
    [Google Scholar]
  13. PuriV. NagpalM. SinghI. SinghM. DhingraG.A. HuanbuttaK. DheerD. SharmaA. SangnimT. A comprehensive review on nutraceuticals: therapy support and formulation challenges.Nutrients20221421463710.3390/nu1421463736364899
    [Google Scholar]
  14. CaoC. XiaoZ. WuY. GeC. Diet and skin aging—from the perspective of food nutrition.Nutrients202012387010.3390/nu1203087032213934
    [Google Scholar]
  15. SteenvoordenD.P.T. Beijersbergen van HenegouwenG.M.J. The use of endogenous antioxidants to improve photoprotection.J. Photochem. Photobiol. B1997411-211010.1016/S1011‑1344(97)00081‑X9440308
    [Google Scholar]
  16. GuY. HanJ. JiangC. ZhangY. Biomarkers, oxidative stress and autophagy in skin aging.Ageing Res. Rev.20205910103610.1016/j.arr.2020.10103632105850
    [Google Scholar]
  17. VachonD.J. YagerD.R. 121 efficient sequestration of neutrophil-derived proteases by a novel polymeric hydrogel.Wound Repair Regen.2004122A3210.1111/j.1067‑1927.2004.0abstractdo.x
    [Google Scholar]
  18. FitsiouE. PulidoT. CampisiJ. AlimirahF. DemariaM. Cellular senescence and the senescence-associated secretory phenotype as drivers of skin photoaging.J. Invest. Dermatol.202114141119112610.1016/j.jid.2020.09.03133349436
    [Google Scholar]
  19. SonY. KimS. ChungH-T. PaeH-O. Reactive Oxygen Species in the Activation of MAP Kinases.Methods in Enzymology.New York Elsevier2013528274810.1016/B978‑0‑12‑405881‑1.00002‑1
    [Google Scholar]
  20. FischerT.A. LudwigS. FloryE. GambaryanS. SinghK. FinnP. PfefferM.A. KellyR.A. PfefferJ.M. Activation of cardiac c-Jun NH(2)-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load.Hypertension20013751222122810.1161/01.HYP.37.5.122211358932
    [Google Scholar]
  21. Cabral-PachecoG.A. Garza-VelozI. Castruita-De la RosaC. Ramirez-AcuñaJ.M. Perez-RomeroB.A. Guerrero-RodriguezJ.F. Martinez-AvilaN. Martinez-FierroM.L. The roles of matrix metalloproteinases and their inhibitors in human diseases.Int. J. Mol. Sci.20202124973910.3390/ijms2124973933419373
    [Google Scholar]
  22. KimK.S. ChoiY.J. JangD.S. LeeS. 2-O-β-d-glucopyranosyl-4,6-dihydroxybenzaldehyde isolated from Morus alba (mulberry) fruits suppresses damage by regulating oxidative and inflammatory responses in TNF-α-induced human dermal fibroblasts.Int. J. Mol. Sci.202223231480210.3390/ijms23231480236499128
    [Google Scholar]
  23. NaylorE.C. WatsonR.E.B. SherrattM.J. Molecular aspects of skin ageing.Maturitas201169324925610.1016/j.maturitas.2011.04.01121612880
    [Google Scholar]
  24. QuanT. ShaoY. HeT. VoorheesJ.J. FisherG.J. Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin.J. Invest. Dermatol.2010130241542410.1038/jid.2009.22419641518
    [Google Scholar]
  25. HeT. QuanT. ShaoY. VoorheesJ.J. FisherG.J. Oxidative exposure impairs TGF-β pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts.Age (Omaha)2014363962310.1007/s11357‑014‑9623‑624550076
    [Google Scholar]
  26. WangA.S. DreesenO. Biomarkers of cellular senescence and skin aging.Front. Genet.2018924710.3389/fgene.2018.0024730190724
    [Google Scholar]
  27. ShinJ.W. KwonS.H. ChoiJ.Y. NaJ.I. HuhC.H. ChoiH.R. ParkK.C. Molecular mechanisms of dermal aging and antiaging approaches.Int. J. Mol. Sci.2019209212610.3390/ijms2009212631036793
    [Google Scholar]
  28. MichalakM. Plant-derived antioxidants: Significance in skin health and the ageing process.Int. J. Mol. Sci.202223258510.3390/ijms2302058535054770
    [Google Scholar]
  29. HillA.B. International markets for genetic resources: Opportunities for Colombia.Int. J. Biotechnol.200021/2/318910.1504/IJBT.2000.000127
    [Google Scholar]
  30. PuriH.S. Neem: The Divine Tree Azadirachta indica (Medicinal and Aromatic Plants - Industrial Profiles Book 5). 1st Ed. Boca Raton: CRC Press 1999.10.4324/9780203304310
    [Google Scholar]
  31. AmbergN. FogarassyC. Green consumer behavior in the cosmetics market.Resources20198313710.3390/resources8030137
    [Google Scholar]
  32. HoangH.T. MoonJ.Y. LeeY.C. Natural antioxidants from plant extracts in skincare cosmetics: recent applications, challenges and perspectives.Cosmetics20218410610.3390/cosmetics8040106
    [Google Scholar]
  33. CasaleF. SuhS. YaleK. MesinkovskaNA Clinical role of oral vitamin C and E therapy in skin and hair disorders.Int. J. Cosmet. Dermatol.202111122010.55124/ijcd.v1i1.44
    [Google Scholar]
  34. SoleymaniS. FarzaeiM.H. ZargaranA. NiknamS. RahimiR. Promising plant-derived secondary metabolites for treatment of acne vulgaris: A mechanistic review.Arch. Dermatol. Res.2020312152310.1007/s00403‑019‑01968‑z31448393
    [Google Scholar]
  35. C Beer, S Wood, RH Veghte. A randomized, double-blind, placebo-controlled clinical trial to investigate the effect of Cynatine® HNS on skin characteristics. Int J Cosm Sci 2013; 35(6): 608-12.10.1111/ics.12084
  36. BuonocoreD. CestoneN. BottoneS. Resveratrol-procyanidin blend: Nutraceutical and antiageing efficacy evaluated in a placebo-controlled, double-blind study.Clin. Cosm. Inves. Derm.20125159-6510.2147/CCID.S36102
    [Google Scholar]
  37. CsekesE. RačkováL. Skin aging, cellular senescence and natural polyphenols.Int. J. Mol. Sci.202122231264110.3390/ijms22231264134884444
    [Google Scholar]
  38. WahabS. AnnaduraiS. AbullaisS.S. DasG. AhmadW. AhmadM.F. KandasamyG. VasudevanR. AliM.S. AmirM. Glycyrrhiza glabra (Licorice): A comprehensive review on its phytochemistry, biological activities, clinical evidence and toxicology.Plants20211012275110.3390/plants1012275134961221
    [Google Scholar]
  39. CiganovićP. JakimiukK. TomczykM. KončićMZ Glycerolic licorice extracts as active cosmeceutical ingredients: Extraction optimization, chemical characterization, and biological activity.Antioxidants201981044510.3390/antiox810044531581512
    [Google Scholar]
  40. PastorinoG. CornaraL. SoaresS. RodriguesF. OliveiraM.B.P.P. Liquorice (Glycyrrhiza glabra ): A phytochemical and pharmacological review.Phytother. Res.201832122323233910.1002/ptr.617830117204
    [Google Scholar]
  41. GunnarsdottirSH SommerauerL. SchnabelT. OostinghG.J. SchusterA. Antioxidative and antimicrobial evaluation of bark extracts from common european trees in light of dermal applications.Antibiotics (Basel)202312113010.3390/antibiotics1201013036671331
    [Google Scholar]
  42. MariniA. Grether-BeckS. JaenickeT. WeberM. BurkiC. FormannP. BrendenH. SchönlauF. KrutmannJ. Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women.Skin Pharmacol. Physiol.2012252869210.1159/00033526122270036
    [Google Scholar]
  43. PintoC.A.S. DelfesM.F.Z. ReisL.M. GarbersL.E. PassosP.C.V.R. TorreD.S. The use of pycnogenol in the treatment of melasma.Surg. Cosmet. Dermatol.20157321822210.5935/scd1984‑8773.201573663
    [Google Scholar]
  44. MyungD.B. LeeJ.H. HanH.S. LeeK.Y. AhnH.S. ShinY.K. SongE. KimB.H. LeeK.H. LeeS.H. LeeK.T. Oral intake of Hydrangea serrata (Thunb.) Ser. leaves extract improves wrinkles, hydration, elasticity, texture, and roughness in human skin: a randomized, double-blind, placebo-controlled study.Nutrients2020126158810.3390/nu1206158832481760
    [Google Scholar]
  45. YoonH.S. KimJ.R. ParkG.Y. KimJ.E. LeeD.H. LeeK.W. ChungJ.H. Cocoa flavanol supplementation influences skin conditions of photo-aged women: A 24-week double-blind, randomized, controlled trial.J. Nutr.20161461465010.3945/jn.115.21771126581682
    [Google Scholar]
  46. FamV.W. HoltR.R. KeenC.L. SivamaniR.K. HackmanR.M. Prospective evaluation of mango fruit intake on facial wrinkles and erythema in postmenopausal women: A randomized clinical pilot study.Nutrients20201211338110.3390/nu1211338133158079
    [Google Scholar]
  47. OchockaR. HeringA. Stefanowicz-HajdukJ. CalK. BarańskaH. The effect of mangiferin on skin: Penetration, permeation and inhibition of ECM enzymes.PLoS One2017127e018154210.1371/journal.pone.018154228750062
    [Google Scholar]
  48. Mallek-AyadiS. BahloulN. BakloutiS. KechaouN. Bioactive compounds from Cucumis melo L. fruits as potential nutraceutical food ingredients and juice processing using membrane technology.Food Sci. Nutr.20221092922293410.1002/fsn3.288836171790
    [Google Scholar]
  49. FamV.W. CharoenwoodhipongP. SivamaniR.K. HoltR.R. KeenC.L. HackmanR.M. Plant-based foods for skin health: A narrative review.J. Acad. Nutr. Diet.2022122361462910.1016/j.jand.2021.10.02434728412
    [Google Scholar]
  50. PugliaC. OffertaA. SaijaA. TrombettaD. VeneraC. Protective effect of red orange extract supplementation against UV -induced skin damages: photoaging and solar lentigines.J. Cosmet. Dermatol.201413215115710.1111/jocd.1208324910279
    [Google Scholar]
  51. TomaR.B. FrankG.C. NakayamaK. TawfikE. Lycopene content in raw tomato varieties and tomato products.J. Foodserv.200819212713210.1111/j.1745‑4506.2008.00094.x
    [Google Scholar]
  52. LinW. WuR.T. WuT. KhorT.O. WangH. KongA.N. Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway.Biochem. Pharmacol.200876896797310.1016/j.bcp.2008.07.03618755157
    [Google Scholar]
  53. MeinkeM. NowbaryC. SchanzerS. VollertH. LademannJ. DarvinM. Influences of orally taken carotenoid-rich curly kale extract on collagen I/elastin index of the skin.Nutrients20179777510.3390/nu9070775
    [Google Scholar]
  54. KangS.J. ChoiB.R. KimS.H. YiH.Y. ParkH.R. SongC.H. KuS.K. LeeY.J. Beneficial effects of dried pomegranate juice concentrated powder on ultraviolet B-induced skin photoaging in hairless mice.Exp. Ther. Med.20171421023103610.3892/etm.2017.462628810554
    [Google Scholar]
  55. KimI.S. Current perspectives on the beneficial effects of soybean isoflavones and their metabolites for humans.Antioxidants2021107106410.3390/antiox1007106434209224
    [Google Scholar]
  56. IzumiT. SaitoM. ObataA. AriiM. YamaguchiH. MatsuyamaA. Oral intake of soy isoflavone aglycone improves the aged skin of adult women.J. Nutr. Sci. Vitaminol. (Tokyo)2007531576210.3177/jnsv.53.5717484381
    [Google Scholar]
  57. TerazawaS. NakajimaH. TobitaK. ImokawaG. The decreased secretion of hyaluronan by older human fibroblasts under physiological conditions is mainly associated with the down-regulated expression of hyaluronan synthases but not with the expression levels of hyaluronidases.Cytotechnology201567460962010.1007/s10616‑014‑9707‑224590928
    [Google Scholar]
  58. OyetakinWhiteP. TriboutH. BaronE. Protective mechanisms of green tea polyphenols in skin.Oxid. Med. Cell. Longev.201220121810.1155/2012/560682
    [Google Scholar]
  59. Di SottoA. GullìM. PercaccioE. VitaloneA. MazzantiG. Di GiacomoS. Efficacy and safety of oral green tea preparations in skin ailments: A systematic review of clinical studies.Nutrients20221415314910.3390/nu1415314935956325
    [Google Scholar]
  60. KimE. HwangK. LeeJ. HanS.Y. KimE.M. ParkJ. ChoJ.Y. Skin protective effect of epigallocatechin gallate.Int. J. Mol. Sci.201819117310.3390/ijms1901017329316635
    [Google Scholar]
  61. SaffariY. SadrzadehS.M.H. Green tea metabolite EGCG protects membranes against oxidative damage in vitro.Life Sci.200474121513151810.1016/j.lfs.2003.08.01914729400
    [Google Scholar]
  62. YounesM. AggettP. AguilarF. CrebelliR. DusemundB. FilipičM. FrutosM.J. GaltierP. GottD. Gundert-RemyU. LambréC. LeblancJ.C. LillegaardI.T. MoldeusP. MortensenA. OskarssonA. StankovicI. Waalkens-BerendsenI. WoutersenR.A. AndradeR.J. FortesC. MosessoP. RestaniP. ArcellaD. PizzoF. SmeraldiC. WrightM. Scientific opinion on the safety of green tea catechins.EFSA J.2018164e0523910.2903/j.efsa.2018.523932625874
    [Google Scholar]
  63. IbrahimM ParveenB ZahiruddinS Analysis of polyphenols in Aegle marmelos leaf and ameliorative efficacy against diabetic mice through restoration of antioxidant and anti-inflammatory status. J Food Biochem.2022464e1385210.1111/jfbc.1385234250628
    [Google Scholar]
  64. FloraS.J.S. Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure.Oxid. Med. Cell. Longev.20092419120610.4161/oxim.2.4.911220716905
    [Google Scholar]
  65. LiguoriI RussoG CurcioF Oxidative stress, ageing, and diseases.Clin Interv Aging.2018261375777510.2147/CIA.S15851329731617
    [Google Scholar]
  66. RahmanA. IbrahimM. SiddiquiJ.I. AnsariS.A. AhmadS. Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat.Clin. Interv. Aging202258e2103210.2147/CIA.S158513
    [Google Scholar]
  67. BaoD. WangJ. PangX. LiuH. Protective effect of quercetin against oxidative stress-induced cytotoxicity in rat pheochromocytoma (PC-12) cells.Molecules2017227112210.3390/molecules2207112228684704
    [Google Scholar]
  68. ParasuramanS. Anand DavidA.V. ArulmoliR. Overviews of biological importance of quercetin: A bioactive flavonoid.Pharmacogn. Rev.20161020848910.4103/0973‑7847.19404428082789
    [Google Scholar]
  69. ShinE.J. LeeJ.S. HongS. LimT.G. ByunS. Quercetin directly targets JAK2 and PKCδ and prevents uv-induced photoaging in human skin.Int. J. Mol. Sci.20192021526210.3390/ijms2021526231652815
    [Google Scholar]
  70. López-CamarilloC. OcampoEA CasamichanaML Pérez-PlasenciaC. Álvarez-SánchezE. MarchatL.A. Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis.Int. J. Mol. Sci.201113114217210.3390/ijms1301014222312244
    [Google Scholar]
  71. CaiW. YuD. FanJ. LiangX. JinH. LiuC. ZhuM. ShenT. ZhangR. HuW. WeiQ. YuJ. Quercetin inhibits transforming growth factor β1-induced epithelial–mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway.Drug Des. Devel. Ther.2018124149416110.2147/DDDT.S18561830584279
    [Google Scholar]
  72. AmalrajA. PiusA. GopiS. GopiS. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review.J. Tradit. Complement. Med.20177220523310.1016/j.jtcme.2016.05.00528417091
    [Google Scholar]
  73. MenonV.P. SudheerA.R. Antioxidant and anti-inflammatory properties of curcumin. In: The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. Aggarwal BB, Surh Y-J, Shishodia S, Eds. Boston, MA: Springer US2007Vol. 59510512510.1007/978‑0‑387‑46401‑5_3
    [Google Scholar]
  74. ZiaA. FarkhondehT. Pourbagher-ShahriA.M. SamarghandianS. The role of curcumin in aging and senescence: Molecular mechanisms.Biomed. Pharmacother.202113411111910.1016/j.biopha.2020.11111933360051
    [Google Scholar]
  75. Bielak-ZmijewskaA. GrabowskaW. CiolkoA. Role of curcumin in the modulation of ageing.Int. J. Mol. Sci.2019205123910.3390/ijms2005123930871021
    [Google Scholar]
  76. JiaY. MaoQ. YangJ. DuN. ZhuY. MinW. (–)-Epigallocatechin-3-gallate protects human skin fibroblasts from ultraviolet a induced photoaging.Clin. Cosmet. Investig. Dermatol.20231614915910.2147/CCID.S39854736704608
    [Google Scholar]
  77. KubatkaP. MazurakovaA. SamecM. KoklesovaL. ZhaiK. AL-IshaqR. KajoK. BiringerK. VybohovaD. BrockmuellerA. PecM. ShakibaeiM. GiordanoF.A. BüsselbergD. GolubnitschajaO. Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways.EPMA J.202112455958710.1007/s13167‑021‑00257‑y34950252
    [Google Scholar]
  78. PalH.C. HuntK.M. DiamondA. ElmetsC.A. AfaqF. Phytochemicals for the management of melanoma.Mini Rev. Med. Chem.2016161295397910.2174/138955751666616021112015726864554
    [Google Scholar]
  79. ZhaoH. ZhuW. ZhaoX. LiX. ZhouZ. ZhengM. MengX. KongL. ZhangS. HeD. XingL. YuJ. Efficacy of epigallocatechin-3-gallate in preventing dermatitis in patients with breast cancer receiving postoperative radiotherapy.JAMA Dermatol.2022158777978610.1001/jamadermatol.2022.173635648426
    [Google Scholar]
  80. SavaskanE. OlivieriG. MeierF. SeifritzE. Wirz-JusticeA. Müller-SpahnF. Red wine ingredient resveratrol protects from β-amyloid neurotoxicity.Gerontology200349638038310.1159/00007376614624067
    [Google Scholar]
  81. Pérez-SánchezA. Barrajón-CatalánE. Herranz-LópezM. MicolV. Nutraceuticals for skin care: A comprehensive review of human clinical studies.Nutrients201810440310.3390/nu1004040329587342
    [Google Scholar]
  82. LeisK. PisankoK. JundziłłA. MazurE. Męcińska-JundziłłK. WitmanowskiH. Resveratrol as a factor preventing skin aging and affecting its regeneration.Postepy Dermatol. Alergol.202239343944510.5114/ada.2022.11754735950117
    [Google Scholar]
  83. CnubbenN.H.P. RietjensI.M.C.M. WortelboerH. van ZandenJ. van BladerenP.J. The interplay of glutathione-related processes in antioxidant defense.Environ. Toxicol. Pharmacol.200110414115210.1016/S1382‑6689(01)00077‑121782570
    [Google Scholar]
  84. ZhangL.X. LiC.X. KakarM.U. KhanM.S. WuP.F. AmirR.M. DaiD.F. NaveedM. LiQ.Y. SaeedM. ShenJ.Q. RajputS.A. LiJ.H. Resveratrol (RV): A pharmacological review and call for further research.Biomed. Pharmacother.202114311216410.1016/j.biopha.2021.11216434649335
    [Google Scholar]
  85. XuL. BotchwayB.O.A. ZhangS. ZhouJ. LiuX. Inhibition of NF-κB signaling pathway by resveratrol improves spinal cord injury.Front. Neurosci.20181269010.3389/fnins.2018.0069030337851
    [Google Scholar]
  86. LephartE.D. Phytoestrogens (resveratrol and equol) for estrogen-deficient skin—controversies/misinformation versus anti-aging in vitro and clinical evidence via nutraceutical-cosmetics.Int. J. Mol. Sci.202122201121810.3390/ijms22201121834681876
    [Google Scholar]
  87. ChangH.C. ChenT.G. TaiY.T. ChenT.L. ChiuW.T. ChenR.M. Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells.J. Cereb. Blood Flow Metab.201131384285410.1038/jcbfm.2010.18020940732
    [Google Scholar]
  88. CaldasA.R. CatitaJ. MachadoR. RibeiroA. CerqueiraF. HortaB. MedeirosR. LúcioM. LopesC.M. Omega-3- and resveratrol-loaded lipid nanosystems for potential use as topical formulations in autoimmune, inflammatory, and cancerous skin diseases.Pharmaceutics2021138120210.3390/pharmaceutics1308120234452163
    [Google Scholar]
  89. SeoS.H. JeongG.S. Fisetin inhibits TNF-α-induced inflammatory action and hydrogen peroxide-induced oxidative damage in human keratinocyte HaCaT cells through PI3K/AKT/Nrf-2-mediated heme oxygenase-1 expression.Int. Immunopharmacol.201529224625310.1016/j.intimp.2015.11.01426590114
    [Google Scholar]
  90. WuP-Y LyuJ-L LiuY-J Fisetin regulates Nrf2 expression and the inflammation-related signaling pathway to prevent uvb-induced skin damage in hairless mice.Int J Mol Sci.20171810211810.3390/ijms1810211828994699
    [Google Scholar]
  91. ChiY.S. KimH.P. Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. Prostaglandins Leukot. Essent. Fatty Acids2005721596610.1016/j.plefa.2004.04.00915589400
    [Google Scholar]
  92. ChiY.S. LimH. ParkH. KimH.P. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression.Biochem. Pharmacol.20036671271127810.1016/S0006‑2952(03)00463‑514505806
    [Google Scholar]
  93. SwansonD. BlockR. MousaS.A. Omega-3 fatty acids EPA and DHA: health benefits throughout life.Adv. Nutr.2012311710.3945/an.111.00089322332096
    [Google Scholar]
  94. CalderP.C. Omega-3 fatty acids and inflammatory processes.Nutrients20102335537410.3390/nu203035522254027
    [Google Scholar]
  95. AraujoP. BelghitI. AarsætherN. EspeM. LucenaE. HolenE. The effect of omega-3 and omega-6 polyunsaturated fatty acids on the production of cyclooxygenase and lipoxygenase metabolites by human umbilical vein endothelial cells.Nutrients201911596610.3390/nu1105096631035600
    [Google Scholar]
  96. HuangT.H. WangP.W. YangS.C. ChouW.L. FangJ.Y. Cosmetic and therapeutic applications of fish oil’s fatty acids on the skin.Mar. Drugs201816825610.3390/md1608025630061538
    [Google Scholar]
  97. ParkeM.A. Perez-SanchezA. ZamilD.H. KattaR. Diet and skin barrier: the role of dietary interventions on skin barrier function.Dermatol. Pract. Concept.2021111e202113210.5826/dpc.1101a13233614213
    [Google Scholar]
  98. PurnamawatiS. IndrastutiN. DanartiR. SaefudinT. The role of moisturizers in addressing various kinds of dermatitis: a review.Clin. Med. Res.2017153-4758710.3121/cmr.2017.136329229630
    [Google Scholar]
  99. KakotiB.B. Hernandez-OntiverosD.G. KatakiM.S. ShahK. PathakY. PanguluriS.K. Resveratrol and omega-3 fatty acid: Its implications in cardiovascular diseases.Front. Cardiovasc. Med.201523810.3389/fcvm.2015.0003826697434
    [Google Scholar]
  100. LarsonM.K. ShearerG.C. AshmoreJ.H. Anderson-DanielsJ.M. GraslieE.L. TholenJ.T. VogelaarJ.L. KorthA.J. NareddyV. SpreheM. HarrisW.S. Omega-3 fatty acids modulate collagen signaling in human platelets.Prostaglandins Leukot. Essent. Fatty Acids2011843-4939810.1016/j.plefa.2010.11.00421177087
    [Google Scholar]
  101. MichalakM. PierzakM. KręciszB. SuligaE. Bioactive compounds for skin health: A review.Nutrients202113120310.3390/nu1301020333445474
    [Google Scholar]
  102. TroeschB. EggersdorferM. LavianoA. RollandY. SmithA.D. WarnkeI. WeimannA. CalderP.C. Expert opinion on benefits of long-chain omega-3 fatty acids (DHA and EPA) in aging and clinical nutrition.Nutrients2020129255510.3390/nu1209255532846900
    [Google Scholar]
  103. SawadaY. Saito-SasakiN. NakamuraM. Omega 3 fatty acid and skin diseases.Front. Immunol.20211162305210.3389/fimmu.2020.62305233613558
    [Google Scholar]
  104. DarvinM.E. LademannJ. von HagenJ. LohanS.B. KolmarH. MeinkeM.C. JungS. Carotenoids in human skin in vivo: Antioxidant and photo-protectant role against external and internal stressors.Antioxidants2022118145110.3390/antiox1108145135892651
    [Google Scholar]
  105. FiedorJ. BurdaK. Potential role of carotenoids as antioxidants in human health and disease.Nutrients20146246648810.3390/nu602046624473231
    [Google Scholar]
  106. BalićA. MokosM. Do we utilize our knowledge of the skin protective effects of carotenoids enough?Antioxidants20198825910.3390/antiox808025931370257
    [Google Scholar]
  107. Grether-BeckS. MariniA. JaenickeT. StahlW. KrutmannJ. Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study.Br. J. Dermatol.201717651231124010.1111/bjd.1508027662341
    [Google Scholar]
  108. JuturuV. BowmanJ. DeshpandeJ. Overall skin tone and skin- lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial.Clin. Cosmet. Investig. Dermatol.2016932533210.2147/CCID.S11551927785083
    [Google Scholar]
  109. PalomboP. FabriziG. RuoccoV. RuoccoE. FluhrJ. RobertsR. MorgantiP. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study.Skin Pharmacol. Physiol.200720419921010.1159/00010180717446716
    [Google Scholar]
  110. AscensoA. PedrosaT. PinhoS. PinhoF. OliveiraJ.M.P.F. Cabral MarquesH. OliveiraH. SimõesS. SantosC. The effect of lycopene preexposure on UV-b-irradiated human keratinocytes.Oxid. Med. Cell. Longev.201620161821463110.1155/2016/821463126664697
    [Google Scholar]
  111. ParradoC. PhilipsN. GilaberteY. JuarranzA. GonzálezS. Oral photoprotection: effective agents and potential candidates.Front. Med.2018518810.3389/fmed.2018.0018829998107
    [Google Scholar]
  112. Northrop-ClewesC.A. ThurnhamD.I. Vitamins. In: The Nutrition Handbook for Food Processors. New York: Elsevier2002349610.1533/9781855736658.1.34
    [Google Scholar]
  113. FerrariS. BonjourJ.P. RizzoliR. The vitamin d receptor gene and calcium metabolism.Trends Endocrinol. Metab.19989725926510.1016/S1043‑2760(98)00065‑418406281
    [Google Scholar]
  114. VanBurenC.A. EvertsH.B. Vitamin A in skin and hair: An update.Nutrients20221414295210.3390/nu1414295235889909
    [Google Scholar]
  115. StahlW. SiesH. β-Carotene and other carotenoids in protection from sunlight.Am. J. Clin. Nutr.20129651179S1184S10.3945/ajcn.112.03481923053552
    [Google Scholar]
  116. ThielitzA. GollnickH. Topical retinoids in acne vulgaris: Update on efficacy and safety.Am. J. Clin. Dermatol.20089636938110.2165/0128071‑200809060‑0000318973403
    [Google Scholar]
  117. ChivotM. Retinoid therapy for acne. A comparative review.Am. J. Clin. Dermatol.200561131910.2165/00128071‑200506010‑0000215675886
    [Google Scholar]
  118. IoannidesD. RigopoulosD. KatsambasA. Topical adapalene gel 0.1% vs. isotretinoin gel 0.05% in the treatment of acne vulgaris: A randomized open-label clinical trial.Br. J. Dermatol.2002147352352710.1046/j.1365‑2133.2002.04873.x12207595
    [Google Scholar]
  119. BagatinE. CostaC.S. The use of isotretinoin for acne – an update on optimal dosing, surveillance, and adverse effects.Expert Rev. Clin. Pharmacol.202013888589710.1080/17512433.2020.179663732744074
    [Google Scholar]
  120. LeungA.K.C. BarankinB. LamJ.M. LeongK.F. HonK.L. Dermatology: how to manage acne vulgaris.Drugs Context20211011810.7573/dic.2021‑8‑634691199
    [Google Scholar]
  121. CookM.K. PercheP.O. FeldmanS.R. The use of oral vitamin A in acne management: A review.Dermatol. Online J.202228510.5070/D32855923936809126
    [Google Scholar]
  122. KennedyD. B vitamins and the brain: mechanisms, dose and efficacy-a review.Nutrients2016826810.3390/nu802006826828517
    [Google Scholar]
  123. ChaudharyP. JanmedaP. DoceaA.O. YeskaliyevaB. Abdull RazisA.F. ModuB. CalinaD. Sharifi-RadJ. Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases.Front Chem.202311115819810.3389/fchem.2023.115819837234200
    [Google Scholar]
  124. PullarJ. CarrA. VissersM. The roles of vitamin C in skin health.Nutrients20179886610.3390/nu908086628805671
    [Google Scholar]
  125. MostafaW.Z. HegazyR.A. Vitamin D and the skin: Focus on a complex relationship: A review.J. Adv. Res.20156679380410.1016/j.jare.2014.01.01126644915
    [Google Scholar]
  126. BochevaG. SlominskiR.M. SlominskiA.T. The impact of vitamin D on skin aging.Int. J. Mol. Sci.20212216909710.3390/ijms2216909734445803
    [Google Scholar]
  127. JanjetovicZ. SlominskiA.T. Promising functions of novel vitamin D derivatives as cosmetics: A new fountain of youth in skin aging and skin protection.Cosmetics20241123710.3390/cosmetics11020037
    [Google Scholar]
  128. KeenM. HassanI. Vitamin E in dermatology.Indian Dermatol. Online J.20167431131510.4103/2229‑5178.18549427559512
    [Google Scholar]
  129. MuzumdarS. FerencziK. Nutrition and youthful skin.Clin. Dermatol.202139579680810.1016/j.clindermatol.2021.05.00734785007
    [Google Scholar]
  130. WeyhC. KrügerK. PeelingP. CastellL. The role of minerals in the optimal functioning of the immune system.Nutrients202214364410.3390/nu1403064435277003
    [Google Scholar]
  131. SalvoJ. SandovalC. Role of copper nanoparticles in wound healing for chronic wounds: Literature review.Burns Trauma202210tkab04710.1093/burnst/tkab04735071652
    [Google Scholar]
  132. Ogen-ShternN. ChuminK. CohenG. BorkowG. Increased pro- collagen 1, elastin, and TGF-β1 expression by copper ions in an ex vivo human skin model.J. Cosmet. Dermatol.20201961522152710.1111/jocd.1318631603269
    [Google Scholar]
  133. RinnerthalerM. StreubelM.K. BischofJ. RichterK. Skin aging, gene expression and calcium.Exp. Gerontol.201568596510.1016/j.exger.2014.09.01525262846
    [Google Scholar]
  134. BarbagalloM. VeroneseN. DominguezL.J. Magnesium in aging, health and diseases.Nutrients202113246310.3390/nu1302046333573164
    [Google Scholar]
  135. MathewA.A. PanonnummalR. ‘Magnesium’-the master cation-as a drug-possibilities and evidences.Biometals202134595598610.1007/s10534‑021‑00328‑734213669
    [Google Scholar]
  136. BjørklundG. ShanaidaM. LysiukR. AntonyakH. KlishchI. ShanaidaV. PeanaM. Selenium: An antioxidant with a critical role in anti-aging.Molecules20222719661310.3390/molecules2719661336235150
    [Google Scholar]
  137. KimJ.E. LeeJ. KimH. KimJ. ChoY. Effect of vitamin C, silicon and iron on collagen synthesis and break-down enzyme expression in the human dermal fibroblast cell (HS27).Kor. J. Nutrit.200942650510.4163/kjn.2009.42.6.505
    [Google Scholar]
  138. AraújoL.A.D. AddorF. CamposP.M.B.G.M. Use of silicon for skin and hair care: an approach of chemical forms available and efficacy.An. Bras. Dermatol.201691333133510.1590/abd1806‑4841.2016398627438201
    [Google Scholar]
  139. GuptaM. MahajanV.K. MehtaK.S. ChauhanP.S. Zinc therapy in dermatology: A review.Dermatol. Res. Pract.2014201411110.1155/2014/70915225120566
    [Google Scholar]
  140. DasL. BhaumikE. RaychaudhuriU. ChakrabortyR. Role of nutraceuticals in human health.J. Food Sci. Technol.201249217318310.1007/s13197‑011‑0269‑423572839
    [Google Scholar]
  141. KocaadamB. ŞanlierN. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health.Crit. Rev. Food Sci. Nutr.201757132889289510.1080/10408398.2015.107719526528921
    [Google Scholar]
  142. DudheR. DudheA.R. ChoudhariN. KatoleG. MahajanR. PathakN. DarodeA. DevnaniD. A review on indian madder as an useful herb.Intern. J. New. Res. Pharm. Heal.202311152110.61554/ijnrph.v1i1.2023.5
    [Google Scholar]
  143. GuptaR. PorteS.M. Manjishtha (Rubia Cordifolia Linn.) An ayurvedic drug: literary review.Int. J. Res. Ayurveda Pharm.201561909710.7897/2277‑4343.06120
    [Google Scholar]
  144. KnottA AchterbergV SmudaC Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects.Biofactors.20154163839010.1002/biof.123926648450
    [Google Scholar]
  145. CaoC. XiaoZ. TongH. LiuY. WuY. GeC. Oral intake of chicken bone collagen peptides anti-skin aging in mice by regulating collagen degradation and synthesis, inhibiting inflammation and activating lysosomes.Nutrients2022148162210.3390/nu1408162235458184
    [Google Scholar]
  146. InoueN. SugiharaF. WangX. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study.J. Sci. Food Agric.201696124077408110.1002/jsfa.760626840887
    [Google Scholar]
  147. OharaH. IchikawaS. MatsumotoH. AkiyamaM. FujimotoN. KobayashiT. TajimaS. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts.J. Dermatol.201037433033810.1111/j.1346‑8138.2010.00827.x20507402
    [Google Scholar]
  148. KellerK.L. FenskeN.A. Uses of vitamins A, C, and E and related compounds in dermatology: A review.J. Am. Acad. Dermatol.199839461162510.1016/S0190‑9622(98)70011‑89777769
    [Google Scholar]
  149. AsserinJ. LatiE. ShioyaT. PrawittJ. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials.J. Cosmet. Dermatol.201514429130110.1111/jocd.1217426362110
    [Google Scholar]
  150. PundirS. GargP. DviwediA. AliA. KapoorV.K. KapoorD. KulshresthaS. LalU.R. NegiP. Ethnomedicinal uses, phytochemistry and dermatological effects of Hippophae rhamnoides L.: A review.J. Ethnopharmacol.202126611343410.1016/j.jep.2020.11343433017636
    [Google Scholar]
  151. LeeJ. JungE. LeeJ. HuhS. KimJ. ParkM. SoJ. HamY. JungK. HyunC.G. KimY.S. ParkD. Panax ginseng induces human Type I collagen synthesis through activation of smad signaling.J. Ethnopharmacol.20071091293410.1016/j.jep.2006.06.00816890388
    [Google Scholar]
  152. BelwalT. DevkotaH.P. HassanH.A. AhluwaliaS. RamadanM.F. MocanA. AtanasovA.G. Phytopharmacology of Acerola (Malpighia enarginata) and its potential as functional food.Trends Food Sci. Technol.2018749910610.1016/j.tifs.2018.01.014
    [Google Scholar]
  153. RizzoJ. MinM. AdnanS. AfzalN. MalohJ. ChambersC.J. FamV. SivamaniR.K. Soy protein containing isoflavones improves facial signs of photoaging and skin hydration in postmenopausal women: Results of a prospective randomized double-blind controlled trial.Nutrients20231519411310.3390/nu1519411337836398
    [Google Scholar]
  154. De LucaC. Mikhal’chikE.V. SuprunM.V. PapacharalambousM. TruhanovA.I. KorkinaL.G. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: A single-blind case-control clinical study.Oxid. Med. Cell. Longev.20162016438941010.1155/2016/438941026904164
    [Google Scholar]
  155. GhatgeA.S. GhatgeS.B. The effectiveness of injectable hyaluronic acid in the improvement of the facial skin quality: A systematic review.Clin. Cosmet. Investig. Dermatol.20231689189910.2147/CCID.S40424837038447
    [Google Scholar]
  156. RaziaS. ParkH. ShinE. ShimK-S. ChoE. KimS-Y. Effects of Aloe vera flower extract and its active constituent isoorientin on skin moisturization via regulating involucrin expression: In vitro and molecular docking studies.Molecules2021269262610.3390/molecules26092626
    [Google Scholar]
  157. RastogiR. LimaG.D. GholapA. Combination of sodium hyaluronate, Withania somnifera extract and niacinamide improves hydration and skin tone – a clinical study.Curr. Cosme. Sci.20232e28082322040910.2174/2666779702666230828094003
    [Google Scholar]
  158. KwatraB. SolankiA. PalM. JasdanwalaS.S. PathakT. Reviewing effects of rosehip, curcumin, piperine and chondroitin sulfate on collagen.Int. J. Pharm. Sci. Rev. Res.20216825148-6410.47583/ijpsrr.2021.v68i01.025
    [Google Scholar]
  159. IvarssonJ.Jr PecorelliA. LilaM.A. ValacchiG. Blueberry supplementation and skin health.Antioxidants2023126126110.3390/antiox1206126137371992
    [Google Scholar]
  160. SharmaP. DwivedeeB.P. BishtD. DashA.K. KumarD. The chemical constituents and diverse pharmacological importance of Tinospora cordifolia. Heliyon201959e0243710.1016/j.heliyon.2019.e0243731701036
    [Google Scholar]
  161. ChaikulP. KanlayavattanakulM. SomkumnerdJ. LourithN. Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging.J. Tradit. Complement. Med.202111539039910.1016/j.jtcme.2021.02.00434522633
    [Google Scholar]
  162. VaughnA.R. BranumA. SivamaniR.K. Effects of turmeric (Curcuma longa ) on skin health: A systematic review of the clinical evidence.Phytother. Res.20163081243126410.1002/ptr.564027213821
    [Google Scholar]
  163. SikandanA. ShinomiyaT. NagaharaY. Ashwagandha root extract exerts anti-inflammatory effects in HaCaT cells by inhibiting the MAPK/NF-κB pathways and by regulating cytokines.Int. J. Mol. Med.201842142543410.3892/ijmm.2018.360829620265
    [Google Scholar]
  164. ParkC. ParkJ. KimW.J. KimW. CheongH. KimS.J. Malonic acid isolated from Pinus densiflora inhibits UVB-induced oxidative stress and inflammation in HaCaT keratinocytes.Polymers (Basel)202113581610.3390/polym1305081633799974
    [Google Scholar]
  165. HuangZ. LiuY. QiG. BrandD. ZhengS. Role of vitamin A in the immune system.J. Clin. Med.20187925810.3390/jcm709025830200565
    [Google Scholar]
  166. PennistonK.L. TanumihardjoS.A. The acute and chronic toxic effects of vitamin A.Am. J. Clin. Nutr.200683219120110.1093/ajcn/83.2.19116469975
    [Google Scholar]
  167. ChenG. WeiskirchenS. WeiskirchenR. Vitamin A: too good to be bad?Front. Pharmacol.202314118633610.3389/fphar.2023.118633637284305
    [Google Scholar]
  168. SchaffellnerS. StadlbauerV. SereiniggM. MìllerH. HögenauerC. FickertP. KrumniklJ. LacknerC. KniepeissD. StauberR.E. Niacin-associated acute hepatotoxicity leading to emergency liver transplantation.Am. J. Gastroenterol.201711281345134610.1038/ajg.2017.17128766583
    [Google Scholar]
  169. Calderon-OspinaC.A. Nava-MesaM.O. Paez-HurtadoA.M. Update on safety profiles of vitamins B1, B6, and B12: A narrative review.Ther. Clin. Risk Manag.2020161275128810.2147/TCRM.S27412233376337
    [Google Scholar]
  170. CarrA. MagginiS. Vitamin C and immune function.Nutrients2017911121110.3390/nu911121129099763
    [Google Scholar]
  171. DosedělM. JirkovskýE. MacákováK. KrčmováL. JavorskáL. PourováJ. MercoliniL. RemiãoF. NovákováL. MladěnkaP. Vitamin C—sources, physiological role, kinetics, deficiency, use, toxicity, and determination.Nutrients202113261510.3390/nu1302061533668681
    [Google Scholar]
  172. MalihiZ. WuZ. LawesC.M.M. ScraggR. Adverse events from large dose vitamin D supplementation taken for one year or longer.J. Steroid Biochem. Mol. Biol.2019188293710.1016/j.jsbmb.2018.12.00230529281
    [Google Scholar]
  173. WiklundRA Vitamin E supplementation and cardiovascular events in high-risk patients.N. Engl. J. Med.200034231546010.1097/00132586‑200012000‑0002210639540
    [Google Scholar]
  174. MillerE.R.III Pastor-BarriusoR. DalalD. RiemersmaR.A. AppelL.J. GuallarE. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality.Ann. Intern. Med.20051421374610.7326/0003‑4819‑142‑1‑200501040‑0011015537682
    [Google Scholar]
  175. BanachW. NitschkeK. KrajewskaN. MongiałłoW. MatuszakO. MuszyńskiJ. SkrypnikD. The association between excess body mass and disturbances in somatic mineral levels.Int. J. Mol. Sci.20202119730610.3390/ijms2119730633022938
    [Google Scholar]
  176. TapieroH. TownsendD.M. TewK.D. Trace elements in human physiology and pathology. Copper.Biomed. Pharmacother.200357938639810.1016/S0753‑3322(03)00012‑X14652164
    [Google Scholar]
  177. PizarroF. OlivaresM. UauyR. ContrerasP. RebeloA. GidiV. Acute gastrointestinal effects of graded levels of copper in drinking water.Environ. Health Perspect.1999107211712110.1289/ehp.991071179924006
    [Google Scholar]
  178. KarimN. Copper and human health- a review.J. Bahr. Univer. Medi. Dent. Coll.20188211712210.51985/JBUMDC2018046
    [Google Scholar]
  179. DuncanA. ForrestJ.A.H. Surreptitious abuse of magnesium laxatives as a cause of chronic diarrhoea.Eur. J. Gastroenterol. Hepatol.200113559960110.1097/00042737‑200105000‑0002311396544
    [Google Scholar]
  180. AraújoC.A.L. LorenaS.B. CavalcantiG.C.S. LeãoG.L.S. TenórioG.P. AlvesJ.G.B. Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial.PLoS One2020151e022749710.1371/journal.pone.022749731923242
    [Google Scholar]
  181. MacFarquharJ.K. BroussardD.L. MelstromP. HutchinsonR. WolkinA. MartinC. BurkR.F. DunnJ.R. GreenA.L. HammondR. SchaffnerW. JonesT.F. Acute selenium toxicity associated with a dietary supplement.Arch. Intern. Med.2010170325626110.1001/archinternmed.2009.49520142570
    [Google Scholar]
  182. WuW.Y. ChouP.L. YangJ.C. ChienC.T. Silicon-containing water intake confers antioxidant effect, gastrointestinal protection, and gut microbiota modulation in the rodents.PLoS One2021163e024850810.1371/journal.pone.024850833788857
    [Google Scholar]
  183. RakhmaninY.A. EgorovaN.A. KrasovskyG.N. MikhailovaR.I. AlekseevaA.V. Silicon: Its biological impact under dietary intake and hygienic standardization of its content in drinking water. A review.Hygi. sanitat.201996549249810.18821/0016‑9900‑2017‑96‑5‑492‑498
    [Google Scholar]
  184. PlumL.M. RinkL. HaaseH. The essential toxin: impact of zinc on human health.Int. J. Environ. Res. Publ. Heal.2010741342136510.3390/ijerph704134220617034
    [Google Scholar]
  185. ChangC.H. TsengP.T. ChenN.Y. LinP.C. LinP.Y. ChangJ.P.C. KuoF.Y. LinJ. WuM.C. SuK.P. Safety and tolerability of prescription omega-3 fatty acids: A systematic review and meta-analysis of randomized controlled trials.Prostaglandins Leukot. Essent. Fatty Acids201812911210.1016/j.plefa.2018.01.00129482765
    [Google Scholar]
  186. CarrJ.A. Role of fish oil in post-cardiotomy bleeding: A summary of the basic science and clinical trials.Ann. Thorac. Surg.201810551563156710.1016/j.athoracsur.2018.01.04129627068
    [Google Scholar]
  187. DetopoulouP. PapamikosV. Gastrointestinal bleeding after high intake of omega-3 fatty acids, cortisone and antibiotic therapy: A case study.Int. J. Sport Nutr. Exerc. Metab.201424325325710.1123/ijsnem.2013‑020424281788
    [Google Scholar]
  188. HalliwellB. Dietary polyphenols: Good, bad, or indifferent for your health?Cardiovasc. Res.200773234134710.1016/j.cardiores.2006.10.00417141749
    [Google Scholar]
  189. Sánchez-FidalgoS. CárdenoA. VillegasI. TaleroE. de la LastraC.A. Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice.Eur. J. Pharmacol.20106331-3788410.1016/j.ejphar.2010.01.02520132809
    [Google Scholar]
  190. NevesA.R. LucioM. LimaJ.L. ReisS. Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions.Curr. Med. Chem.201219111663168110.2174/09298671279994508522257059
    [Google Scholar]
  191. MazzantiG. Di SottoA. VitaloneA. Hepatotoxicity of green tea: an update.Arch. Toxicol.20158981175119110.1007/s00204‑015‑1521‑x25975988
    [Google Scholar]
  192. LundhK. HindsénM. GruvbergerB. MöllerH. SvenssonÅ. BruzeM. Contact allergy to herbal teas derived from Asteraceae plants.Contact Dermat.200654419620110.1111/j.0105‑1873.2006.00709.x16650094
    [Google Scholar]
  193. HuZ. YangX. HoP.C.L. ChanS.Y. HengP.W.S. ChanE. DuanW. KohH.L. ZhouS. Herb-drug interactions.Drugs20056591239128210.2165/00003495‑200565090‑0000515916450
    [Google Scholar]
  194. SharmaD. RashidG. SharmaL. Probiotics.(1st ed.).Boca Raton: CRC Press202432534310.1201/9781003452249‑15
    [Google Scholar]
  195. AjmalRS BeniwalM.K. SengarG.S. Septicemia: As a result of erroneous parenteral administration of probiotic.Ind. J. Case Repo.202283727410.32677/ijcr.v8i3.3323
    [Google Scholar]
  196. KodentsovaV.M. RisnikD.V. MoiseenokA.G. Algorithm for effective use of vitamin and mineral supplements.J. The Grodno State Medi. Univer.202422217718410.25298/2221‑8785‑2024‑22‑2‑177‑184
    [Google Scholar]
  197. NasriH. BaradaranA. ShirzadH. Rafieian-KopaeiM. New concepts in nutraceuticals as alternative for pharmaceuticals.Int. J. Prev. Med.20145121487149925709784
    [Google Scholar]
  198. WangK. Adverse Reaction Prediction and Pharmacovigilance of Nutraceuticals.Nutraceuticals. New York Elsevier201623924810.1016/B978‑0‑12‑802147‑7.00019‑X
    [Google Scholar]
  199. KhanS. IbrahimM. A systematic review on hepatoprotective potential of grape and polyphenolic compounds: Molecular mechanism and future prospective.Natu. Resour. Hum. Heal.20223219621310.53365/nrfhh/156261
    [Google Scholar]
  200. AndrewR. IzzoA.A. Principles of pharmacological research of nutraceuticals.Br. J. Pharmacol.2017174111177119410.1111/bph.1377928500635
    [Google Scholar]
  201. HelalN.A. EassaH.A. AmerA.M. EltokhyM.A. EdafioghoI. NounouM.I. Nutraceuticals’ novel formulations: The good, the bad, the unknown and patents involved.Recent Pat. Drug Deliv. Formul.201913210515610.2174/187221131366619050311204031577201
    [Google Scholar]
  202. GehmB.D. McAndrewsJ.M. ChienP.Y. JamesonJ.L. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor.Proc. Natl. Acad. Sci. USA19979425141381414310.1073/pnas.94.25.141389391166
    [Google Scholar]
  203. ZaborowskiM.K. DługoszA. BłaszakB. SzulcJ. LeisK. The role of quercetin as a plant-derived bioactive agent in preventive medicine and treatment in skin disorders.Molecules20242913320610.3390/molecules2913320638999158
    [Google Scholar]
  204. SusanCK StephenMP ThomasDG Erythropoietic protoporphyria.Ped. Derm.20071438310.1111/j.1525‑1470.2007.00383.x
    [Google Scholar]
/content/journals/cpd/10.2174/0113816128336661250218080928
Loading
/content/journals/cpd/10.2174/0113816128336661250218080928
Loading

Data & Media loading...


  • Article Type:
    Review Article
Keyword(s): minerals; nutraceuticals; Skin ageing; skin anti-ageing, EGCG; vitamins
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test