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Abstract

Niacinamide, a water-soluble derivative of vitamin B3, has emerged as a versatile compound with wide-ranging therapeutic potential in dermatology. This review critically examines its formulation strategies, mechanisms of action, clinical benefits, safety profile, and advancements in delivery technologies. Niacinamide exhibits anti-inflammatory, antioxidant, and barrier-strengthening properties, making it valuable in the treatment of acne, rosacea, hyperpigmentation, and skin aging. It regulates sebum secretion, diminishes inflammatory lesions, supports collagen production, and protects against photoaging. Clinical studies affirm its effectiveness in enhancing skin tone, texture, and barrier integrity, with minimal adverse effects, even with prolonged use. Innovations in drug delivery, such as microencapsulation, liposomal carriers, and nanoparticle-based systems, have enhanced its dermal absorption and stability. Looking ahead, the integration of niacinamide into combination therapies and tailored skincare regimens offers promising opportunities to maximize its clinical utility. Overall, niacinamide stands out as a multifunctional dermatological agent with significant potential for promoting skin health and rejuvenation.

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2025-12-15

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References

  1. Boo Y.C. Mechanistic basis and clinical evidence for the applications of nicotinamide (niacinamide) to control skin aging and pigmentation. Antioxidants 2021 10 8 1315 10.3390/antiox10081315 34439563
    [Google Scholar]
  2. Rolfe H.M. A review of nicotinamide: Treatment of skin diseases and potential side effects. J. Cosmet. Dermatol. 2014 13 4 324 328 10.1111/jocd.12119 25399625
    [Google Scholar]
  3. Marques C. Hadjab F. Porcello A. Lourenço K. Scaletta C. Abdel-Sayed P. Hirt-Burri N. Applegate L.A. Laurent A. Mechanistic insights into the multiple functions of niacinamide: Therapeutic implications and cosmeceutical applications in functional skincare products. Antioxidants 2024 13 4 425 10.3390/antiox13040425 38671873
    [Google Scholar]
  4. Park H.J. Byun K.A. Oh S. Kim H.M. Chung M.S. Son K.H. Byun K. The combination of niacinamide, vitamin C, and pdrn mitigates melanogenesis by modulating nicotinamide nucleotide transhydrogenase. Molecules 2022 27 15 4923 10.3390/molecules27154923 35956878
    [Google Scholar]
  5. Surjana D. Halliday G.M. Damian D.L. Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin. Carcinogenesis 2013 34 5 1144 1149 10.1093/carcin/bgt017 23349012
    [Google Scholar]
  6. Soma Y. Kashima M. Imaizumi A. Takahama H. Kawakami T. Mizoguchi M. Moisturizing effects of topical nicotinamide on atopic dry skin. Int. J. Dermatol. 2005 44 3 197 202 10.1111/j.1365‑4632.2004.02375.x 15807725
    [Google Scholar]
  7. Kamat J.P. Devasagayam T.P.A. Nicotinamide (vitamin B3) as an effective antioxidant against oxidative damage in rat brain mitochondria. Redox Rep. 1999 4 4 179 184 10.1179/135100099101534882 10658823
    [Google Scholar]
  8. Qian H. Shan Y. Gong R. Lin D. Zhang M. Wang C. Wang L. Mechanism of action and therapeutic effects of oxidative stress and stem cell-based materials in skin aging: Current evidence and future perspectives. Front. Bioeng. Biotechnol. 2023 10 1082403 10.3389/fbioe.2022.1082403 36698629
    [Google Scholar]
  9. Zhao Y. Simon M. Seluanov A. Gorbunova V. DNA damage and repair in age-related inflammation. Nat. Rev. Immunol. 2023 23 2 75 89 10.1038/s41577‑022‑00751‑y 35831609
    [Google Scholar]
  10. Desnita R. Luliana S. Kasim Z. Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation. Pharmaciana 2018 8 2 296 10.12928/pharmaciana.v8i2.7696
    [Google Scholar]
  11. Menon A.R.M. Adams M.H. González M.A. Tolbert D.S. Leu J.H. Cefali E.A. Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation. Int. J. Clin. Pharmacol. Ther. 2007 45 8 448 454 10.5414/CPP45448 17725178
    [Google Scholar]
  12. Draelos Z.D. Ertel K. Berge C. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Cutis 2005 76 2 135 141 16209160
    [Google Scholar]
  13. Gundala N.K.V. Naidu V.G.M. Das U.N. Arachidonic acid and lipoxin A4 attenuate alloxan‐induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo. Biofactors 2017 43 2 251 271 10.1002/biof.1336 27862450
    [Google Scholar]
  14. Bains P. Kaur M. Kaur J. Sharma S. Nicotinamide: Mechanism of action and indications in dermatology. Indian J. Dermatol. Venereol. Leprol. 2018 84 2 234 237 10.4103/ijdvl.IJDVL_286_17 29405129
    [Google Scholar]
  15. Cooper D.L. Murrell D.E. Roane D.S. Harirforoosh S. Effects of formulation design on niacin therapeutics: Mechanism of action, metabolism, and drug delivery. Int. J. Pharm. 2015 490 1-2 55 64 10.1016/j.ijpharm.2015.05.024 25987211
    [Google Scholar]
  16. Final report of the safety assessment of niacinamide and niacin. Int. J. Toxicol. 2005 24 Suppl. 5 1 31 10.1080/10915810500434183 16596767
    [Google Scholar]
  17. Radojkovic B. Milić J. Calija B. Compounding of slow-release niacinamide capsules: Feasibility and characterization 2012 Available from: https://europepmc.org/article/med/23072204
  18. Dănilă E. Kaya D.A. Anuța V. Popa L. Coman A.E. Chelaru C. Constantinescu R.R. Dinu-Pîrvu C. Albu Kaya M.G. Ghica M.V. Formulation and characterization of niacinamide and collagen emulsion and its investigation as a potential cosmeceutical product. Cosmetics 2024 11 2 40 10.3390/cosmetics11020040
    [Google Scholar]
  19. Sohn J.S. Choi J.S. Development and evaluation of niacinamide transdermal formulation by artificial membrane permeability. Saudi Pharm. J. 2023 31 7 1229 1236 10.1016/j.jsps.2023.05.018 37284416
    [Google Scholar]
  20. Fateha binti Sukor, N.; binti Jusoh, R.; Syahirah binti Kamarudin, N. Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation. Mater. Today Proc. 2024 107 46 52 10.1016/j.matpr.2023.06.379
    [Google Scholar]
  21. Mizoguchi H. Li J. Whittenbarger D.J. Marmor M.J. Jerajani H.R. The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: A randomized, double-blind trial. Indian J. Dermatol. Venereol. Leprol. 2010 76 1 20 26 10.4103/0378‑6323.58674 20061726
    [Google Scholar]
  22. Ganceviciene R. Liakou A.I. Theodoridis A. Makrantonaki E. Zouboulis C.C. Skin anti-aging strategies. Dermatoendocrinol 2012 4 3 308 319 10.4161/derm.22804
    [Google Scholar]
  23. Hakozaki T. Minwalla L. Zhuang J. Chhoa M. Matsubara A. Miyamoto K. Greatens A. Hillebrand G.G. Bissett D.L. Boissy R.E. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br. J. Dermatol. 2002 147 1 20 31 10.1046/j.1365‑2133.2002.04834.x 12100180
    [Google Scholar]
  24. Rani S. Banik K.B. Rath S. Formulation and evaluation of dermatological product containing niacinamide. Adv. Exp. Med. Biol. 2021 1337 331 337 10.1007/978‑3‑030‑78771‑4_37 34972921
    [Google Scholar]
  25. Bissett D.L. Miyamoto K. Sun P. Li J. Berge C.A. Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. Int. J. Cosmet. Sci. 2004 26 5 231 238 10.1111/j.1467‑2494.2004.00228.x 18492135
    [Google Scholar]
  26. Wohlrab J. Kreft D. Niacinamide - mechanisms of action and its topical use in dermatology. Skin Pharmacol. Physiol. 2014 27 6 311 315 10.1159/000359974 24993939
    [Google Scholar]
  27. Smith J.G. Parish L.C. Sofman M.S. Chalker D.K. Topical nicotinamide compared with clindamycin gel in the treatment of inelammatory acne vulgaris. Int. J. Dermatol. 1995 34 434 437 10.1111/j.1365‑4362.1995.tb04449.x 7657446
    [Google Scholar]
  28. Berry K. Hallock K. Lam C. Photoaging and topical rejuvenation. Facial Plast. Surg. Clin. North Am. 2022 30 3 291 300 10.1016/j.fsc.2022.03.003 35934431
    [Google Scholar]
  29. Levin J. Momin S.B. How much do we really know about our favorite cosmeceutical ingredients? J. Clin. Aesthet. Dermatol. 2010 3 2 22 41 20725560
    [Google Scholar]
  30. Farris P.K. Topical vitamin C: A useful agent for treating photoaging and other dermatologic conditions. Dermatol. Surg. 2005 31 7 Pt 2 814 817 10.1111/j.1524‑4725.2005.31725 16029672
    [Google Scholar]
  31. Namazi M.R. Nicotinamide: A potential addition to the anti‐psoriatic weaponry. FASEB J. 2003 17 11 1377 1379 10.1096/fj.03‑0002hyp 12890690
    [Google Scholar]
  32. Navarrete-Solís J. Castanedo-Cázares J.P. Torres-Álvarez B. Oros-Ovalle C. Fuentes-Ahumada C. González F.J. Martínez-Ramírez J.D. Moncada B. A double-blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma. Dermatol. Res. Pract. 2011 2011 1 5 10.1155/2011/379173 21822427
    [Google Scholar]
  33. Kameyama K. Sakai C. Kondoh S. Yonemoto K. Nishiyama S. Tagawa M. Murata T. Ohnuma T. Quigley J. Dorsky A. Bucks D. Blanock K. Inhibitory effect of magnesium l-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo. J. Am. Acad. Dermatol. 1996 34 1 29 33 10.1016/S0190‑9622(96)90830‑0 8543691
    [Google Scholar]
  34. Imokawa G. Ishida K. Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging I: Reduced skin elasticity, highly associated with enhanced dermal elastase activity, triggers wrinkling and sagging. Int. J. Mol. Sci. 2015 16 4 7753 7775 10.3390/ijms16047753 25856675
    [Google Scholar]
  35. Jacobson E.L. Kim H. Kim M. Williams J.D. Coyle D.L. Coyle W.R. Grove G. Rizer R.L. Stratton M.S. Jacobson M.K. A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin. Exp. Dermatol. 2007 16 6 490 499 10.1111/j.1600‑0625.2007.00553.x 17518989
    [Google Scholar]
  36. Pillaiyar T. Namasivayam V. Manickam M. Jung S.H. Inhibitors of melanogenesis: An updated review. J. Med. Chem. 2018 61 17 7395 7418 10.1021/acs.jmedchem.7b00967 29763564
    [Google Scholar]
  37. Lee Y.J. Jang S.G. Ryu M.J. Choi S.H. Nicotinamide riboside ameliorates hyperpigmentation on photo-irradiated skin. Cosmetics 2024 11 3 73 10.3390/cosmetics11030073
    [Google Scholar]
  38. Ronchi J.A. Francisco A. Passos L.A.C. Figueira T.R. Castilho R.F. The contribution of nicotinamide nucleotide transhydrogenase to peroxide detoxification is dependent on the respiratory state and counterbalanced by other sources of nadph in liver mitochondria. J. Biol. Chem. 2016 291 38 20173 20187 10.1074/jbc.M116.730473 27474736
    [Google Scholar]
  39. Allouche J. Rachmin I. Adhikari K. Pardo L.M. Lee J.H. McConnell A.M. Kato S. Fan S. Kawakami A. Suita Y. Wakamatsu K. Igras V. Zhang J. Navarro P.P. Lugo C.M. Noonan H.R. Christie K.A. Itin K. Mujahid N. Lo J.A. Won C.H. Evans C.L. Weng Q.Y. Wang H. Osseiran S. Lovas A. Németh I. Cozzio A. Navarini A.A. Hsiao J.J. Nguyen N. Kemény L.V. Iliopoulos O. Berking C. Ruzicka T. Gonzalez-José R. Bortolini M.C. Canizales-Quinteros S. Acuna-Alonso V. Gallo C. Poletti G. Bedoya G. Rothhammer F. Ito S. Schiaffino M.V. Chao L.H. Kleinstiver B.P. Tishkoff S. Zon L.I. Nijsten T. Ruiz-Linares A. Fisher D.E. Roider E. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell 2021 184 16 4268 4283.e20 10.1016/j.cell.2021.06.022 34233163
    [Google Scholar]
  40. Qin H. Zhang G. Zhang L. GSK126 (EZH2 inhibitor) interferes with ultraviolet A radiation induced photoaging of human skin fibroblast cells. Exp. Ther. Med. 2018 15 4 3439 3448 10.3892/etm.2018.5863 29545866
    [Google Scholar]
  41. Zhou X. Du H.H. Ni L. Ran J. Hu J. Yu J. Zhao X. Nicotinamide mononucleotide combined with Lactobacillus fermentum TKSN041 reduces the photoaging damage in murine skin by activating ampk signaling pathway. Front. Pharmacol. 2021 12 643089 10.3389/fphar.2021.643089 33841160
    [Google Scholar]
  42. Torres-Moral T. Tell-Martí G. Bague J. Rosés-Gibert P. Calbet-Llopart N. Mateu J. Pérez-Anker J. Potrony M. Alejo B. Iglesias P. Espinosa N. Orte Cano C. Cinotti E. Del Marmol V. Fontaine M. Miyamoto M. Monnier J. Perrot J.L. Rubegni P. Tognetti L. Suppa M. Demessant-Flavigny A.L. Le Floc’h C. Prieto L. Malvehy J. Puig S. Evaluation of the biological effect of a nicotinamide-containing broad-spectrum sunscreen on photodamaged skin. Dermatol. Ther. 2024 14 12 3321 3336 10.1007/s13555‑024‑01298‑7 39509031
    [Google Scholar]
  43. Kawada A. Konishi N. Oiso N. Kawara S. Date A. Evaluation of anti‐wrinkle effects of a novel cosmetic containing niacinamide. J. Dermatol. 2008 35 10 637 642 10.1111/j.1346‑8138.2008.00537.x 19017042
    [Google Scholar]
  44. Wessels Q. Pretorius E. Smith C.M. Nel H. The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro. Int. Wound J. 2014 11 2 152 158 10.1111/j.1742‑481X.2012.01052.x 22892041
    [Google Scholar]
  45. Zouboulis C.C. Abdel-Naser M.B. Acne and its variants. In: Therapy of Skin Diseases: A Worldwide Perspective on Therapeutic Approaches and Their Molecular Basis 2010 359 373 10.1007/978‑3‑540‑78814‑0_34
    [Google Scholar]
  46. Smith R.N. Mann N.J. Braue A. Mäkeläinen H. Varigos G.A. The effect of a high-protein, low glycemic–load diet versus a conventional, high glycemic–load diet on biochemical parameters associated with acne vulgaris: A randomized, investigator-masked, controlled trial. J. Am. Acad. Dermatol. 2007 57 2 247 256 10.1016/j.jaad.2007.01.046 17448569
    [Google Scholar]
  47. Walocko F.M. Eber A.E. Keri J.E. AL-Harbi, M.A.; Nouri, K. The role of nicotinamide in acne treatment. Dermatol. Ther. 2017 30 5 12481 10.1111/dth.12481 28220628
    [Google Scholar]
  48. Khodaeiani E. Fouladi R.F. Amirnia M. Saeidi M. Karimi E.R. Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris. Int. J. Dermatol. 2013 52 8 999 1004 10.1111/ijd.12002 23786503
    [Google Scholar]
  49. Liu H. Yu H. Xia J. Liu L. Liu G. Sang H. Peinemann F. Evidence‐based topical treatments (azelaic acid, salicylic acid, nicotinamide, sulfur, zinc, and fruit acid) for acne: An abridged version of a Cochrane systematic review. J. Evid. Based Med. 2020 13 4 275 283 10.1111/jebm.12411 33034949
    [Google Scholar]
  50. Markovics A. Tóth K.F. Sós K.E. Magi J. Gyöngyösi A. Benyó Z. Zouboulis C.C. Bíró T. Oláh A. Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA 2). J. Cell. Mol. Med. 2019 23 9 6203 6214 10.1111/jcmm.14505 31273921
    [Google Scholar]
  51. Kafa A.H.T. Tüzün G. Güney E. Aslan R. Sayın K. Tüzün B. Ataseven H. Synthesis, computational analyses, antibacterial and antibiofilm properties of nicotinamide derivatives. Struct. Chem. 2022 33 4 1189 1197 10.1007/s11224‑022‑01927‑x
    [Google Scholar]
  52. Akinyele O.F. Fakola E.G. George R.C. Durosinmi L.M. Synthesis, characterization and antibacterial activity of mixed ligand complexes of Nicotinamide and 2,2′-Bipyridine. Ife J. Sci. 2021 23 1 213 222 10.4314/ijs.v23i1.18
    [Google Scholar]
  53. Algarin Y.A. Pulumati A. Jaalouk D. Tan J. Nouri K. The role of vitamins and nutrients in rosacea. Arch. Dermatol. Res. 2024 316 5 142 10.1007/s00403‑024‑02895‑4 38695936
    [Google Scholar]
  54. Bissett D.L. Oblong J.E. Berge C.A. Niacinamide. Dermatol. Surg. 2005 31 s1 860 866 10.1111/j.1524‑4725.2005.31732 16029679
    [Google Scholar]
  55. Pazoki-Toroudi H. Nassiri-Kashani M. Tabatabaie H. Ajami M. Habibey R. Shizarpour M. Babakoohi S. Rahshenas M. Firooz A. Combination of azelaic acid 5% and erythromycin 2% in the treatment of acne vulgaris. J. Dermatolog. Treat. 2010 21 3 212 216 10.3109/09546630903440064 20394495
    [Google Scholar]
  56. Pazoki-Toroudi H. Nilforoushzadeh M.A. Ajami M. Jaffary F. Aboutaleb N. Nassiri-Kashani M. Firooz A. Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris. Cutan. Ocul. Toxicol. 2011 30 4 286 291 10.3109/15569527.2011.581257 21612319
    [Google Scholar]
  57. Soma M. Lalam S.K. The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions. Mol. Biol. Rep. 2022 49 10 9737 9748 10.1007/s11033‑022‑07459‑1 35441939
    [Google Scholar]
  58. Song Q. Zhou X. Xu K. Liu S. Zhu X. Yang J. The safety and antiaging effects of nicotinamide mononucleotide in human clinical trials: An update. Adv. Nutr. 2023 14 6 1416 1435 10.1016/j.advnut.2023.08.008 37619764
    [Google Scholar]
  59. Kiss T. Nyúl-Tóth Á. Balasubramanian P. Tarantini S. Ahire C. Yabluchanskiy A. Csipo T. Farkas E. Wren J.D. Garman L. Csiszar A. Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: Transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience 2020 42 2 527 546 10.1007/s11357‑020‑00165‑5 32056076
    [Google Scholar]
  60. Zhang Y. Ai C. Huang F. Zhao J.L. Ling Y. Chen W. Li Z. Wang Y. Gao F. Li S. Gao W. Wang Y. β-Nicotinamide mononucleotide blocks UVB-induced collagen reduction via regulation of ROS/MAPK/AP-1 and stimulation of mitochondrial proline biosynthesis. Photochem. Photobiol. Sci. 2025 24 2 293 306 10.1007/s43630‑025‑00692‑0 40025354
    [Google Scholar]
  61. Snaidr VA. Damian DL. Halliday GM. Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Exp. Dermatol. 2019 28 Suppl. 1 15 22 10.1111/exd.13819 30698874
    [Google Scholar]
  62. Kang S. Park J. Cheng Z. Ye S. Jun S.H. Kang N.G. Novel approach to skin anti-aging: boosting pharmacological effects of exogenous nicotinamide adenine dinucleotide (NAD+) by synergistic inhibition of CD38 expression. Cells 2024 13 21 1799 10.3390/cells13211799 39513906
    [Google Scholar]
  63. Tanno O. Ota Y. Kitamura N. Katsube T. Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br. J. Dermatol. 2000 143 3 524 531 10.1111/j.1365‑2133.2000.03705.x 10971324
    [Google Scholar]
  64. Forbat E. Al-Niaimi F. Ali F.R. Use of nicotinamide in dermatology. Clin. Exp. Dermatol. 2017 42 2 137 144 10.1111/ced.13021 28052374
    [Google Scholar]
  65. Ding Y. Li Y. Wen A. Effect of niacin on lipids and glucose in patients with type 2 diabetes: A meta-analysis of randomized, controlled clinical trials. Clin. Nutr. 2015 34 5 838 844 10.1016/j.clnu.2014.09.019 25306426
    [Google Scholar]
  66. Hwang E. Song S. Possible adverse effects of high-dose nicotinamide: Mechanisms and safety assessment. Biomolecules 2020 10 5 687 10.3390/biom10050687 32365524
    [Google Scholar]
  67. Zhang W. Shi X. Zheng S. Study on influencing factors of nicotinamide transdermal absorption in vitro and the establishment of an evaluation method. Processes 2024 12 1 202 10.3390/pr12010202
    [Google Scholar]
  68. Basto R. Andrade R. Nunes C. Lima S.A.C. Reis S. Topical delivery of niacinamide to skin using hybrid nanogels enhances photoprotection effect. Pharmaceutics 2021 13 11 1968 10.3390/pharmaceutics13111968 34834383
    [Google Scholar]
  69. Yu K. Wang Y. Wan T. Zhai Y. Cao S. Ruan W. Wu C. Xu Y. Tacrolimus nanoparticles based on chitosan combined with nicotinamide: Enhancing percutaneous delivery and treatment efficacy for atopic dermatitis and reducing dose. Int. J. Nanomed 2017 13 129 142 10.2147/IJN.S150319 29317821
    [Google Scholar]
  70. Zhang H. George-Washburn E.A. Hashemi K.B. Cho E. Walker J. Weinstock M.A. Bostom A. Robinson-Bostom L. Gohh R. Oral nicotinamide for actinic keratosis prevention in kidney transplant recipients: A pilot double-blind, randomized, placebo-controlled trial. Transplant. Proc. 2023 55 9 2079 2084 10.1016/j.transproceed.2023.06.016 37838527
    [Google Scholar]
  71. Chen A.C. Martin A.J. Choy B. Fernández-Peñas P. Dalziell R.A. McKenzie C.A. Scolyer R.A. Dhillon H.M. Vardy J.L. Kricker A. St George G. Chinniah N. Halliday G.M. Damian D.L. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention. N. Engl. J. Med. 2015 373 17 1618 1626 10.1056/NEJMoa1506197 26488693
    [Google Scholar]
  72. Martin A.J. Chen A. Choy B. Penas P.F. Halliday G. Dalziell R. McKenzie C. Scolyer R.A. Dhillon H.M. Vardy J.L. St George G. Chinniah N. Damian D. Oral nicotinamide to reduce actinic cancer: A phase 3 double-blind randomized controlled trial. J. Clin. Oncol. 2015 33 15_suppl. 9000 9000 10.1200/jco.2015.33.15_suppl.9000
    [Google Scholar]
  73. Surjana D. Halliday G.M. Martin A.J. Moloney F.J. Damian D.L. Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. J. Invest. Dermatol. 2012 132 5 1497 1500 10.1038/jid.2011.459 22297641
    [Google Scholar]
  74. Draelos Zoe D. The latest cosmeceutical approaches for anti‐aging. J. Cosmet. Dermatol. 2007 6 s1 2 6 10.1111/j.1473‑2165.2007.00313.x
    [Google Scholar]
  75. Yang X. Tang Y. Wang M. Wang Y. Wang W. Pang M. Xu Y. Co-delivery of methotrexate and nicotinamide by cerosomes for topical psoriasis treatment with enhanced efficacy. Int. J. Pharm. 2021 605 120826 10.1016/j.ijpharm.2021.120826 34171426
    [Google Scholar]
  76. Prausnitz M.R. Engineering microneedle patches for vaccination and drug delivery to skin. Annu. Rev. Chem. Biomol. Eng. 2017 10.1146/annurev‑chembioeng‑060816‑101514
    [Google Scholar]
  77. Lv J. Zhao J. Li X. Ling G. Zhang P. Preparation of a novel hyaluronic acid-based separable hydrogel microneedle with niacinamide to treat pigment deposition using solvent-free solid-state crosslinking method. Eur. Polym. J. 2024 210 113003 10.1016/j.eurpolymj.2024.113003
    [Google Scholar]
  78. Al-Niaimi F. Zhen Chiang N Z 2017 Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5605218/
  79. King S. Campbell J. Rowe R. Daly M.L. Moncrieff G. Maybury C. A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging. J. Cosmet. Dermatol. 2023 22 10 2650 2662 10.1111/jocd.15923 37550898
    [Google Scholar]
  80. Fivenson D.P. The mechanisms of action of nicotinamide and zinc in inflammatory skin disease. 2006 Available from: https://pubmed.ncbi.nlm.nih.gov/16871773/
    [Google Scholar]
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Exploring Niacinamide as a Multifunctional Agent for Skin Health and Rejuvenation
Bentham Science Publishers ; https://doi.org/10.2174/0113892010402025250922222646
/content/journals/cpb/10.2174/0113892010402025250922222646
/content/journals/cpb/10.2174/0113892010402025250922222646
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  • Article Type:     Review Article
Keywords: antioxidant ; Niacinamide ; skin health ; dermatology ; barrier function ; anti-inflammatory

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