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Abstract

In the pursuit of innovative vaccine delivery methods, this review explores the potential of spray drying for formulating inhalable vaccines. Traditional vaccine approaches face challenges in administration, storage, and accessibility, especially in resource-limited settings. Inhalable vaccines, utilizing techniques like spray drying, offer a promising solution. By bypassing systemic circulation and directly targeting the respiratory mucosa, inhalable vaccines can induce robust mucosal and systemic immune responses. Spray drying, a versatile technique, is particularly well-suited for formulating inhalable vaccines. It transforms liquid vaccine formulations into finely dispersed powders, enabling efficient delivery to the lungs. This review delves into the unique characteristics of spray-dried particles, their impact on immune system activation, and their role in overcoming traditional vaccine limitations. The exploration emphasizes the potential for spray drying to revolutionize vaccine development, providing a comprehensive overview of its applications and contributions to improving global public health.

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2025-07-29
2025-09-19

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/content/journals/cpb/10.2174/0113892010352443250402184623
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Spray Drying: A Promising Technique for Inhalable Vaccine Development
Bentham Science Publishers ; https://doi.org/10.2174/0113892010352443250402184623
/content/journals/cpb/10.2174/0113892010352443250402184623
/content/journals/cpb/10.2174/0113892010352443250402184623
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  • Article Type:     Review Article
Keywords: immune response ; Inhalable vaccine ; dry powder vaccine ; particle characteristics ; spray drying ; systemic immune response ; pulmonary delivery ; respiratory mucosa

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