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2000
Volume 26, Issue 10
  • ISSN: 1389-2010
  • E-ISSN: 1873-4316

Abstract

Despite advanced clinical treatment, the mortality rate of cancer patients is high. Recent studies have linked the development of cancer to inflammation. Many cancers are exacerbated by the emergence of inflammatory responses, and non-coding RNAs play an important role in inflammation. Non-coding RNAs include microRNAs, circular RNAs, long-chain non-coding RNAs, . The non-coding RNA regulatory network composed of microRNAs, circular RNAs and long-chain non-coding RNAs is involved in the regulatory process of multiple gene expression. They can act on various signaling pathways, such as wnt/β-catenin, nuclear factor-kappa B, phosphatidylinositol 3 kinase/ AKT, mitogen-activated protein kinase, and so on. These signaling pathways can control the occurrence of inflammatory response to some extent, such as regulating the expression of inflammatory cytokines (such as interleukin-6, interferon-gamma, tumor necrosis factor-α, and so on), making them upregulated or down-regulated. Therefore, it is important to study the role of non-coding RNAs in inflammation to contribute to the future of cancer.

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/content/journals/cpb/10.2174/0113892010295993240430125552
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The Cross-talk of Non-coding RNAs and Inflammation in Human Cancer
Current Pharmaceutical Biotechnology 26, 1596 (2025); https://doi.org/10.2174/0113892010295993240430125552
/content/journals/cpb/10.2174/0113892010295993240430125552
/content/journals/cpb/10.2174/0113892010295993240430125552
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  • Article Type:     Review Article
Keyword(s): 3 kinase/ AKT; Cross-Talk; human cancer; inflammation; mitogen-activated protein kinase; non-coding RNAs

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