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2000
Volume 12, Issue 2
  • ISSN: 2213-3372
  • E-ISSN: 2213-3380

Abstract

Background

Developing environmentally benign processes, such as organic reactions conducted in water, is desired from the view of sustainable technology. Concerning the palladium-catalyzed borylation reactions of aryl halides in water, only a few examples have been reported.

Objective

This study aimed to develop efficient methods for palladium-catalyzed borylation reactions of aryl halides in water, not only increasing product yields but also extracting products with less organic solvents.

Methods

We adopted polymer surfactants, such as diblock copolymers that consist of poly(N-isopropoylacrylamide) and a hydrophilic segment, and a poly(ethylene glycol)-based polymer that consists of poly(ethylene glycol) chain and 4-chloromethylbenzyl moiety.

Results

Reactions using these polymers gave the borylation products in significantly higher yields than that in pure water. The efficiency of the extraction process for the products from the reaction mixtures was evaluated, indicating that the polymer micelles enabled separation processes with less organic solvent.

Conclusion

Applying polymer surfactants increased the product yields in Pd-catalyzed borylation of aryl halides, and it enabled the extraction of the products from the aqueous reaction mixture more efficiently.

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2025-10-29

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Palladium-Catalyzed Borylation of Aryl Halides in Water Using Poly (Ethylene Glycol)-Based Surfactants
Curr. Organocatal. 12, 157 (2025); https://doi.org/10.2174/0122133372355594241211060459
/content/journals/cocat/10.2174/0122133372355594241211060459
/content/journals/cocat/10.2174/0122133372355594241211060459
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  • Article Type:     Research Article
Keyword(s): borylation; palladium catalyst; poly(ethylene glycol); poly(N-isopropylacrylamide); polymer micelle; Reaction in water

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