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2000
Volume 12, Issue 2
  • ISSN: 2213-3372
  • E-ISSN: 2213-3380

Abstract

Background

Hydrazide derivatives were synthesized using an organocatalyst, offering an environmentally friendly approach characterized by shorter reaction times, mild conditions, and the use of green solvents.

Objective

The objective was to evaluate the synthesized compounds for their anti-tubercular activity against (Mtb) and to assess the cytotoxicity of active compounds using the MTT assay.

Methods

Ultrasound energy was employed to facilitate the synthesis of the compounds. The resulting compounds were tested for their activity against (Mtb), and the active compounds were further evaluated for cytotoxicity using the 3-(4,5-dimethylthiazol-2-yl) -2,5- diphenyl tetrazolium bromide MTT assay.

Results

Several compounds demonstrated activity against Mtb, with some derivatives exhibiting a Minimum Inhibitory Concentration (MIC) of 1.56 µg/mL, comparable to the standard anti-tubercular drug Ethambutol.

Conclusion

The eco-friendly synthesis of hydrazide derivatives shows significant potential in the development of anti-tubercular agents, with some compounds displaying efficacy similar to established drugs.

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