
Full text loading...
Hydrazide derivatives were synthesized using an organocatalyst, offering an environmentally friendly approach characterized by shorter reaction times, mild conditions, and the use of green solvents.
The objective was to evaluate the synthesized compounds for their anti-tubercular activity against Mycobacterium tuberculosis (Mtb) and to assess the cytotoxicity of active compounds using the MTT assay.
Ultrasound energy was employed to facilitate the synthesis of the compounds. The resulting compounds were tested for their activity against Mycobacterium tuberculosis (Mtb), and the active compounds were further evaluated for cytotoxicity using the 3-(4,5-dimethylthiazol-2-yl) -2,5- diphenyl tetrazolium bromide MTT assay.
Several compounds demonstrated activity against Mtb, with some derivatives exhibiting a Minimum Inhibitory Concentration (MIC) of 1.56 µg/mL, comparable to the standard anti-tubercular drug Ethambutol.
The eco-friendly synthesis of hydrazide derivatives shows significant potential in the development of anti-tubercular agents, with some compounds displaying efficacy similar to established drugs.