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2000
Volume 12, Issue 2
  • ISSN: 2213-3372
  • E-ISSN: 2213-3380

Abstract

Introduction

The Developed CuO-ZnO nanocomposite has been demonstrated as a new and environmentally friendly catalyst for one-pot multicomponent reaction between aldehydes, 2-naphthol and amides in the synthesis of 1-amidoalkyl-2-naphthols.

Methods

The new catalyst was synthesized by a ball-milling method by mixing a mixture of CuO and ZnO powder in various proportions and characterized by different spectroscopic methods such as powder X-ray diffraction (pXRD), Scanning Electron Microscopy (SEM), UV-Visible analysis, EDAX elemental analysis and mapping. The advantages of the devised protocol include a green approach, simple work-up procedures, avoidance of hazardous solvents, and good to excellent yields.

Results

Evaluation of the catalyst performance in the synthesis of some 1-amidoalkyl-2-naphthols showed presentable results. Sixteen derivatives were synthesized in desirable yield by our new method (-). CuO-ZnO nanocomposite as a safe and efficient catalyst could be reused up to 5 runs for the synthesis of naphthol derivatives without any significant decrease in its potency.

Conclusion

The High purity of the products and desirable yields are other points that make the present work more attractive.

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2025-09-02

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/content/journals/cocat/10.2174/0122133372337451240923173335
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Nano-reusable CuO-ZnO Catalyzed One-Pot Synthesis of 1-Amidoalkyl-2-Naphthols under Green Condition
Curr. Organocatal. 12, 104 (2025); https://doi.org/10.2174/0122133372337451240923173335
/content/journals/cocat/10.2174/0122133372337451240923173335
/content/journals/cocat/10.2174/0122133372337451240923173335
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  • Article Type:     Research Article
Keyword(s): 1-amidoalkyl-2-naphthols; green chemistry; heterogeneous catalyst; multicomponent reaction; Nanocomposite; naphthol derivatives

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