Application of Multi-component Reaction in the Synthesis of Heterocyclic [3.3.3] Propellane Derivatives

Propellanes and derivatives have attractive properties due to their unique structure. Therefore, [3.3.3] propellanes, containing tricyclic structures with one of the carbon-carbon bonds common in three rings, were used in natural products, pharmaceutical compounds, and heterocyclic compounds, which were biologically important. The various multi-component reactions were applied in the synthesis of propellanes, which are highlighted throughout this review.