Chemistry and Biological Activity of [1,2,3]-Benzotriazine Derivatives

[1,2,3]-Benzotriazines represent an interesting category of heterocyclic compounds. Various synthetic methods, key reactions and biological aspects have been highlighted. In particular, some analogues have shown antitumor activity. [1,2,3]- Benzotriazin-4-one derivatives are applied extensively as herbicides, insecticides and nematicides. Incorporation of these compounds into the human food chain is a cause of concern, since their toxicity to man is well documented. This review is an attempt to discuss synthesis, chemical reactions, applications and pharmacological aspects of [1,2,3]- benzotriazine analogues from 1957 till date.