Synthesis of 1-Sulfonylpyrrolidines via Cycloaddition Reactions

Many biologically active compounds possess 1-sulfonyl pyrrolidine structural motif. Therefore, the development of facile methods for the preparation of these compounds in optically pure form is relevant. One of the regio- and stereoselective approaches to the pyrrolidine derivatives is cycloaddition. Thus, this review article is an attempt to survey literature describing synthetic methods for the preparation of 1-sulfonyl pyrrolidine derivatives via various cycloaddition reactions.