Current Applications of the Sonogashira Reaction in the Synthesis of Heterocyclic Compounds: An Update

The Sonogashira cross-coupling reaction involves the coupling of terminal alkynes with aryl or vinyl halides in the presence of a Pd and a Cu(I) co-catalyst. We tried to reveal the importance of the applications of the Sonogashira reaction in the synthesis of heterocyclic compounds. The reactions occur under relatively mild conditions and tolerate a wide variety of functional groups.