Preparation of Acridine Derivatives Bearing Saturated Rings

This review presents possible routs of preparation of acridine derivatives con-taining saturated rings that can be obtained both as a result of traditional organic synthesis based on cyclization and condensation reactions and whenever available by partial or total catalytic (heterogeneous or homogeneous) hydrogenation of appropriate acridine derivatives. Methods of preparations of acridine derivatives bearing saturated rings are presented and discussed. The influence of resonance stabilisation energies of N-heteroaromatic and partly saturated N-heteroaromatic structures on hydrogenation susceptibility is discussed in relation to other aspects influencing saturation N-heteroaromatic versus carbocyclic rings.