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- ISSN: 1385-2728
- E-ISSN: 1875-5348
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Synthesis of New β-Carboline Derivatives Fused with β-Lactam Rings: An Experimental and Theoretical Study
- Source: Current Organic Chemistry, Volume 17, Issue 17, Sep 2013, p. 1894 - 1902
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- 01 Sep 2013
Abstract
The Staudinger reaction of various β-carboline derivatives with aryloxyacetyl chlorides led to novel fused tetracyclic compounds containing two biologically considerable cores, such as the β-carboline and the β-lactam units. The reaction is stereoselective, giving exclusively the cis cycloadducts as racemates. The mechanism and the 100% stereoselectivity of this cycloaddition was studied by high level quantum chemical calculations.
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