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2000
Volume 14, Issue 14
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

The 1,3-dipolar cycloaddition reaction of nitrile oxides with carbon dipolarophiles is a versatile and powerful synthetic method to prepare isoxazolines. In particular nitrile oxide cycloaddition reactions with exocyclic methylene or alkylidene compounds generally proceed regioselectively leading to spiro heterocyclic compounds. This review deals with progress in the field of nitrile oxide cycloaddition chemistry for the synthesis of spiro isoxazolines.

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/content/journals/coc/10.2174/138527210791616812
2010-08-01
2025-09-02

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  • Article Type:     Research Article
Keyword(s): dipolar cycloaddition; exocyclic methylene; heterocycle; isoxazoline; Nitrile oxide; spiro

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