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2000
Volume 30, Issue 5
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

is a genus of woody trees in the family Meliaceae. Due to the appearance of numerous bioactive compounds, it was widely used in traditional medicines. The current research aims to provide an extensive overview of phytochemical and pharmacological values. To find the English references, a thorough search of numerous electronic data sources, such as Web of Science, PubMed, Google Scholar, and Science Direct, was conducted. The “Sci-Finder” was used to confirm chemical structures and references. Documents that have been cited date back to the 1970s. The best keywords for the collection of articles are “”, “phytochemistry”, and “pharmacology”. Phytochemical investigations of extracts led to the separation of more than 270 secondary metabolites. They included limonoids, triterpenoids, sesquiterpenoids, phytosterols, chirol-inositols, flavonoids, and others. Various compounds were new in the literature. constituents possessed various pharmacological activities, including cytotoxicity, anti-inflammatory, antioxidative, antidiabetic, anti-obesity, antibacterial, antimalarial, tyrosinase inhibitory, mosquito larvicidal, and neuroprotective activities. Some compounds are better than standard agents in biological experiments. Apoptosis is the main pathway of anticancer compounds, whereas cytokine inhibition may be attributed to their anti-inflammatory actions. The studied genus is a good source of limonoids, terpenoids, and phytosterols with various pharmacological potentials.

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2026-02-26

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The Genus Chisocheton: An Extensive Review of Phytochemistry and Pharmacology
Current Organic Chemistry 30, 345 (2026); https://doi.org/10.2174/0113852728382432250527075453
/content/journals/coc/10.2174/0113852728382432250527075453
/content/journals/coc/10.2174/0113852728382432250527075453
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  • Article Type:     Review Article
Keyword(s): Chisocheton; cytotoxicity; limonoid; Meliaceae; pharmacology; phytochemistry

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