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2000
Volume 30, Issue 4
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

A well-known heterocyclic scaffold, imidazopyridine, is recognized for its important role in the development of therapeutic drugs. This is because imidazopyridine possesses a wide range of biological characteristics. The aim of this study is to provide a comprehensive outline of various synthetic techniques (2018˗2024) employed in the synthesis of Imidazo[1,2˗a] pyridine derivatives, highlighting both traditional and modern methodologies. The review article includes approaches like one-pot and microwave˗assisted synthesis in addition to traditional multistep synthesis. The review also looks at green chemistry strategies, emphasizing environmentally friendly techniques that reduce the usage of dangerous solvents and reagents. It includes forty different synthetic strategies, with respect to “green” methods, “one˗pot” reactions, “microwave˗assisted” methods, and “cyclization˗based” strategies. This review aims to assist researchers in selecting the most effective strategies for the efficient synthesis of imidazopyridine derivatives, thereby promoting their broader application in medicinal chemistry and related fields.

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/content/journals/coc/10.2174/0113852728367154250617095504
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Exploring Synthesis and Functionalization of Imidazo[1,2˗a]pyridines: A Promising Heterocyclic Framework
Current Organic Chemistry 30, 245 (2026); https://doi.org/10.2174/0113852728367154250617095504
/content/journals/coc/10.2174/0113852728367154250617095504
/content/journals/coc/10.2174/0113852728367154250617095504
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  • Article Type:     Review Article
Keyword(s): green approaches; Imidazo[1,2-a]pyridine; microwave˗assisted synthesis; nitrogen; one-pot synthesis; synthesis via cyclization

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