Skip to content
2000
Volume 4, Issue 1
  • ISSN: 2665-9786
  • E-ISSN: 2665-9794

Abstract

Background

The immense genetic variety found in plants and microbes provides a plethora of opportunities for human advancement in the creation of medicine. Microorganisms have been exceptionally rich sources of drugs. Nowadays, the emergence of new infectious diseases and the resistance of some pathogenic microbes necessitates further attempts to find new antimicrobial agents in the fight against infections.

Objective

The main goal of this study was to explore and evaluate the biologically active secondary metabolites from selected desert flora-associated microorganisms.

Methods

This was achieved through the isolation of bacteria and fungi associated with plants selected from diverse parts of the Saudi Arabian desert. This study was directed to test the optimal microbial culture composition for the production of biologically active metabolites against pathogenic microbes.

Results

The produced secondary metabolites showed profound antibiosis activities. Some of which were comparable to or more potent than some of the currently used antibiotics.

Conclusion

These findings lay the foundation for further discoveries of new metabolites that are urgently needed to face the uprising microbial resistance and mutations that the whole world is continuously suffering from.

Loading

Article metrics loading...

/content/journals/cnt/10.2174/2665978604666230525144506
2023-08-01
2025-09-02
Loading full text...

Full text loading...

References

  1. Abdel-RazekA.S. El-NaggarM.E. AllamA. MorsyO.M. OthmanS.I. Microbial natural products in drug discovery.Processes (Basel)20208447010.3390/pr8040470
    [Google Scholar]
  2. RadulovićN.S. BlagojevićP.D. Stojanović-RadićZ.Z. StojanovićN.M. Antimicrobial plant metabolites: Structural diversity and mechanism of action.Curr. Med. Chem.201320793295223210781
    [Google Scholar]
  3. Ali-ShtayehM.S. YaghmourR.M.R. FaidiY.R. SalemK. Al-NuriM.A. Antimicrobial activity of 20 plants used in folkloric medicine in the Palestinian area.J. Ethnopharmacol.199860326527110.1016/S0378‑8741(97)00153‑09613839
    [Google Scholar]
  4. The top 10 causes of death.2020Available from: who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death
  5. AatiH. El-GamalA. ShaheenH. KayserO. Traditional use of ethnomedicinal native plants in the Kingdom of Saudi Arabia.J. Ethnobiol. Ethnomed.2019151210.1186/s13002‑018‑0263‑230626417
    [Google Scholar]
  6. LimbagoB. M100-S11, Performance standards for antimicrobial susceptibility testing.Clin. Microbiol. Newsl.20012364910.1016/S0196‑4399(01)88009‑0
    [Google Scholar]
  7. JonesP. GarciaB.J. FurchesA. TuskanG.A. JacobsonD. Plant host-associated mechanisms for microbial selection.Front. Plant Sci.201910July86210.3389/fpls.2019.0086231333701
    [Google Scholar]
  8. ZhouL. LiX. Kotta-LoizouI. DongK. LiS. NiD. HongN. WangG. XuW. A mycovirus modulates the endophytic and pathogenic traits of a plant associated fungus.ISME J.20211571893190610.1038/s41396‑021‑00892‑333531623
    [Google Scholar]
  9. SchulzB. BoyleC. The endophytic continuum.Mycol. Res.2005109666168610.1017/S095375620500273X16080390
    [Google Scholar]
  10. MeftehF.B. DaoudA. Chenari BouketA. AleneziF.N. LuptakovaL. RatebM.E. KadriA. GharsallahN. BelbahriL. Fungal root microbiome from healthy and brittle leaf diseased date palm trees (Phoenix Dactylifera L.) reveals a hidden untapped arsenal of antibacterial and broad spectrum antifungal secondary metabolites.Front. Microbiol.20178FEB30710.3389/fmicb.2017.0030728293229
    [Google Scholar]
  11. PerveenK. Antibacterial activity of Phoenix dactylifera L. leaf and pit extracts against selected gram negative and gram positive pathogenic bacteria.J. Med. Plants Res.201262296300
    [Google Scholar]
  12. TalebH. MaddocksS.E. MorrisR.K. KanekanianA.D. Chemical characterisation and the anti-inflammatory, antiangiogenic and antibacterial properties of date fruit (Phoenix dactylifera L.).J. Ethnopharmacol.201619445746810.1016/j.jep.2016.10.03227729284
    [Google Scholar]
  13. SamySelim Susceptibility of imipenem-resistant Pseudomonas aeruginosa to flavonoid glycosides of date palm (Phoenix dactylifera L.) tamar growing in Al Madinah, Saudi Arabia.Afr. J. Biotechnol.201111241642210.5897/AJB11.1412
    [Google Scholar]
  14. Kardan-YamchiJ. MahboubiM. KazemianH. HamzelouG. FeizabadiM.M. The chemical composition and antimycobacterial activities of Trachyspermum copticum and Pelargonium graveolens essential oils.Recent Patents Anti-Infect. Drug Disc.2020151687410.2174/22124071MTAxfOTUvx31657682
    [Google Scholar]
  15. RajaR.R. Medicinally potential plants of labiatae (lamiaceae) family: An overview.Res. J. Med. Plant20126320321310.3923/rjmp.2012.203.213
    [Google Scholar]
  16. EssidR. HammamiM. GharbiD. KarkouchI. HamoudaT.B. ElkahouiS. LimamF. TabbeneO. Antifungal mechanism of the combination of Cinnamomum verum and Pelargonium graveolens essential oils with fluconazole against pathogenic Candida strains.Appl. Microbiol. Biotechnol.2017101186993700610.1007/s00253‑017‑8442‑y28766033
    [Google Scholar]
  17. EnnaiferM. BouzaieneT. MessaoudC. HamdiM. Phytochemicals, antioxidant, anti-acetyl-cholinesterase, and antimicrobial activities of decoction and infusion of Pelargonium graveolens.Nat. Prod. Res.202034182634263810.1080/14786419.2018.154729930584784
    [Google Scholar]
  18. YasserM.M. MarzoukM.A. El-ShafeyN.M. ShabanS.A. Diversity and antimicrobial activity of endophytic fungi from the medicinal plant Pelargonium graveolens (Geranium) in middle Egypt.Jordan J. Biol. Sci.2020132197205
    [Google Scholar]
  19. ReisA.C.C. SilvaB.M. de MouraH.M.M. PereiraG.R. BrandãoG.C. Anti-Zika virus activity and chemical characterization by ultra-high performance liquid chromatography (UPLC-DAD-UV-MS) of ethanol extracts in Tecoma species.BMC Complementary Med Ther202020124610.1186/s12906‑020‑03040‑032767975
    [Google Scholar]
  20. Robles-ZepedaR.E. Velázquez-ContrerasC.A. Garibay-EscobarA. Gálvez-RuizJ.C. Ruiz-BustosE. Antimicrobial activity of Northwestern Mexican plants against Helicobacter pylori.J. Med. Food201114101280128310.1089/jmf.2010.026321663492
    [Google Scholar]
  21. BakrR. FayedM.A. SalemM. HusseinA. Tecoma stans: Alkaloid profile and antimicrobial activity.J. Pharm. Bioallied Sci.201911434134710.4103/jpbs.JPBS_79_1931619916
    [Google Scholar]
  22. PatriotaL.L.S. ProcópioT.F. de SouzaM.F.D. de OliveiraA.P.S. CarvalhoL.V.N. PittaM.G.R. RegoM.J.B.M. PaivaP.M.G. PontualE.V. NapoleãoT.H. A trypsin inhibitor from tecoma stans leaves inhibits growth and promotes atp depletion and lipid peroxidation in Candida albicans and Candida krusei.Front. Microbiol.2016761110.3389/fmicb.2016.0061127199940
    [Google Scholar]
  23. DhayalanM. DenisonM.I.J. AyyarM. GandhiN.N. KrishnanK. AbdulhadiB. Biogenic synthesis, characterization of gold and silver nanoparticles from Coleus forskohlii and their clinical importance.J. Photochem. Photobiol. B201818325125710.1016/j.jphotobiol.2018.04.04229734113
    [Google Scholar]
  24. SyedaA.M. RiazunnisaK. Data on GC-MS analysis, in vitro anti-oxidant and anti-microbial activity of the Catharanthus roseus and Moringa oleifera leaf extracts.Data Brief20202910525810.1016/j.dib.2020.10525832154338
    [Google Scholar]
  25. PhamH.N.T. SakoffJ.A. VuongQ.V. BowyerM.C. ScarlettC.J. Phytochemical, antioxidant, anti-proliferative and antimicrobial properties of Catharanthus roseus root extract, saponin-enriched and aqueous fractions.Mol. Biol. Rep.20194633265327310.1007/s11033‑019‑04786‑830945069
    [Google Scholar]
  26. MaemaL.P. PotgieterM. MasevheN.A. SamieA. Antimicrobial activity of selected plants against fungal species isolated from South African AIDS patients and their antigonococcal activity.J. Complement. Integr. Med.20201732019008710.1515/jcim‑2019‑008732301751
    [Google Scholar]
  27. SimonettiG. BrasiliE. PasquaG. Antifungal activity of phenolic and polyphenolic compounds from different matrices of Vitis vinifera L. against human pathogens.Molecules20202516374810.3390/molecules2516374832824589
    [Google Scholar]
  28. AhmadS. AbdEl-SalamN.M. UllahR. In vitro antimicrobial bioassays, DPPH radical scavenging activity, and ftir spectroscopy analysis of Heliotropium bacciferum.BioMed Res. Int.2016201611210.1155/2016/381894527597961
    [Google Scholar]
  29. FalanaM.B. NurudeenQ.O. Evaluation of phytochemical constituents and in vitro antimicrobial activities of leaves extracts of Calotropis procera against certain human pathogens.Not. Sci. Biol.202012220822110.15835/nsb12210699
    [Google Scholar]
  30. RaniR. SharmaD. ChaturvediM. Parkash YadavJ. Antibacterial activity of twenty different endophytic fungi isolated from calotropis procera and time kill assay.Clin Microbiol.201763100028010.4172/2327‑5073.1000280
    [Google Scholar]
  31. SalahF. GhoulY.E. MahdhiA. MajdoubH. JarrouxN. SakliF. Effect of the deacetylation degree on the antibacterial and antibiofilm activity of acemannan from Aloe vera.Ind. Crops Prod.2017103131810.1016/j.indcrop.2017.03.031
    [Google Scholar]
  32. SaddiqA.A. Al-GhamdiH. Aloe vera extract: A novel antimicrobial and antibiofilm against methicillin resistant Staphylococcus aureus strains.Pak. J. Pharm. Sci.2018315SupplementarySuppl.2123213030393222
    [Google Scholar]
  33. ChandrakarS. GuptaA.K. Actinomycin-producing endophytic streptomyces parvulus associated with root of aloe vera and optimization of conditions for antibiotic production.Probiotics Antimicrob. Proteins20191131055106910.1007/s12602‑018‑9451‑630058033
    [Google Scholar]
  34. Habid OueslatiM. BouajilaJ. Ben JannetH. Two new bioactive biphenylpropanoids from the roots of Salsola imbricata (Chenopodiaceae) growing in Saudi Arabia.Orient. J. Chem.20173341871187810.13005/ojc/330432
    [Google Scholar]
/content/journals/cnt/10.2174/2665978604666230525144506
Loading
/content/journals/cnt/10.2174/2665978604666230525144506
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test