Skip to content
2000
Volume 5, Issue 1
  • ISSN: 2665-9786
  • E-ISSN: 2665-9794

Abstract

Up to 10% people in the world are affected by a chronic condition known as peptic ulcer. Peptic ulcer development is influenced by the pH of gastric juice and a decline in mucosal defenses. Proton-pump inhibitors, histamine (H) receptor antagonists, prostaglandin analogues and sucralfate have all been used to treat peptic ulcer disease. There has been a continuing search for an appropriate, palliative, and curative agent for the treatment of peptic ulcer disease using natural materials of plant and animal origin due to the complexity, cost, and toxicity of these medications. The goal of this review was to examine medicinal plants, phytochemicals, pathways, and research models that have been applied to the treatment of Peptic ulcer disease (PUD) in order to assess the potential contribution of natural substances to the development of herbal treatments for PUD. A literature search was used to find information utilising electronic databases such as Web of Science, Google Scholar, PubMed, Sci Finder, Reaxys, and Cochrane.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cnt/10.2174/0126659786247721231117110442
2023-12-06
2025-11-01

  • From This Site

    /content/journals/cnt/10.2174/0126659786247721231117110442
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. NietoB.Y. Therapeutic protocol of peptic ulcer.Med201211179182
     [Google Scholar]
  2. BennetP.N. BrownM. Clinical Pharmacology.9th edNew DelhiChurchill Livingstone Publication2006625632
     [Google Scholar]
  3. HelmsR.A. HerfindalE.T. QuanD.J. GourleyD.R. Peptic ulcer disease and gastroesophageal reflux disease.Text Book of Therapeutics Drug and Disease Management.8th edPhiladelphiaLippincott Williams and Wilkin200612271256
     [Google Scholar]
  4. TarnawskiA. SzaboI.L. HusainS.S. SoreghanB. Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways.J. Physiol. Paris2001951-633734410.1016/S0928‑4257(01)00046‑8 11595458
     [Google Scholar]
  5. AvramM. Peptic ulcer disease.Surg. Clin. North Am.19765612771284
     [Google Scholar]
  6. BasG. EryilmazR. OkanI. SahinM. Risk factors of morbidity and mortality in patients with perforated peptic ulcer.Acta Chir. Belg.2008108442442710.1080/00015458.2008.11680254 18807594
     [Google Scholar]
  7. VairaD. MenegattiM. MiglioliM. What is the role of Helicobacter pylori in complicated ulcer disease?Gastroenterology19971136S78S8410.1016/S0016‑5085(97)80017‑0 9394765
     [Google Scholar]
  8. DongoA.E. UhunmwaghoO. KesiemeE.B. EluehikeS.U. AlufohaiE.F. A five-year review of perforated peptic ulcer disease in Irrua, Nigeria.Int. Sch. Res. Notices201720171610.1155/2017/8375398 28656171
     [Google Scholar]
  9. WilliamsN. BullstrodeC. ConnellP.O. Stomach and duodenum.Bailey and Love’s Short Practice of Surgery.26th edLondon, UKCRC2013
     [Google Scholar]
  10. MalikT.F. GnanapandithanK. SinghK. Peptic Ulcer Disease.Treasure Island, FLStatPearls2022
     [Google Scholar]
  11. LanasÁ. Carrera-LasfuentesP. ArguedasY. GarcíaS. BujandaL. CalvetX. PonceJ. Perez-AísaÁ. CastroM. MuñozM. SostresC. García-RodríguezL.A. Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants.Clin. Gastroenterol. Hepatol.2015135906912.e210.1016/j.cgh.2014.11.007 25460554
     [Google Scholar]
  12. MascleeG.M.C. ValkhoffV.E. ColomaP.M. de RidderM. RomioS. SchuemieM.J. HeringsR. GiniR. MazzagliaG. PicelliG. ScottiL. PedersenL. KuipersE.J. van der LeiJ. SturkenboomM.C.J.M. Risk of upper gastrointestinal bleeding from different drug combinations.Gastroenterology20141474784792.e910.1053/j.gastro.2014.06.007 24937265
     [Google Scholar]
  13. HuangJ.Q. SridharS. HuntR.H. Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: A meta-analysis.Lancet20023599300142210.1016/S0140‑6736(02)07273‑2 11809181
     [Google Scholar]
  14. ChalyaP.L. MabulaJ.B. KoyM. MchembeM.D. JakaH.M. KabangilaR. ChandikaA.B. GilyomaJ.M. Clinical profile and outcome of surgical treatment of perforated peptic ulcers in Northwestern Tanzania: A tertiary hospital experience.World J. Emerg. Surg.2011613110.1186/1749‑7922‑6‑31 21871104
     [Google Scholar]
  15. AnbalakanK. ChuaD. PandyaG.J. ShelatV.G. Five year experience in management of perforated peptic ulcer and validation of common mortality risk prediction models - Are existing models sufficient? A retrospective cohort study.Int. J. Surg.201514384410.1016/j.ijsu.2014.12.022 25560748
     [Google Scholar]
  16. KaoL.T. TsaiM.C. LinH.C. PaiF. LeeC.Z. Weekly pattern of emergency room admissions for peptic ulcers: A population-based study.World J. Gastroenterol.201521113344335010.3748/wjg.v21.i11.3344 25805943
     [Google Scholar]
  17. BandyopadhyayD. BiswasK. BhattacharyyaM. ReiterR. BanerjeeR. Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: Protection by melatonin.Curr. Mol. Med.20011450151310.2174/1566524013363483 11899094
     [Google Scholar]
  18. WiseL. Peptic ulcer: A reappraisal of its aetiology.Ann. R. Coll. Surg. Engl.1972503145163 4259236
     [Google Scholar]
  19. ScullyC. ShottsR. ABC of oral health: Mouth ulcers and other causes of orofacial soreness and pain.BMJ2000321725416216510.1136/bmj.321.7254.162 10894697
     [Google Scholar]
  20. TillissT.S.I. McDowellJ.D. Differential diagnosis: Is it herpes or aphthous? J. Contemp. Dent. Pract.20021001015
     [Google Scholar]
  21. ScullyC. PorterS. Recurrent aphthous stomatitis: Current concepts of etiology, pathogenesis and management.J. Oral Pathol. Med.1989181212710.1111/j.1600‑0714.1989.tb00727.x 2664131
     [Google Scholar]
  22. AxéllT. HenricssonV. Association between recurrent aphthous ulcers and tobacco habits.Eur. J. Oral Sci.198593323924210.1111/j.1600‑0722.1985.tb01951.x 3860909
     [Google Scholar]
  23. AyoubF. KhullarV. BanerjeeD. StonerP. LambrouT. WesterveldD.R. HanaynehW. KamelA.Y. EstoresD. Once versus twice-daily oral proton pump inhibitor therapy for prevention of peptic ulcer rebleeding: A propensity score-matched analysis.Gastroenterol. Res.201811320020610.14740/gr1011w 29915630
     [Google Scholar]
  24. GnanapandithanK. SharmaA. Mesenteric Vasculitis.Treasure Island, FLStatPearls2021
     [Google Scholar]
  25. BhupeshK.V. AlokM. AmitaV. ShantiM. AlkaV. Preclinical screening of antiulcer activity of asparagus racemosus extract on phenylbutazone induced ulceration in experimental animals. J. Med. Plants.Stud.20175348352
     [Google Scholar]
  26. BhajoniP.S. MeshramG.G. LahkarM. Evaluation of the antiulcer activity of the leaves of Azadirachta indica: An experimental study.Integr. Med. Int.201631-2101610.1159/000442750
     [Google Scholar]
  27. AhlamH.M. EbtehalM.F. DaliaB.F. Antiulcer activity of citharexylum quadrangulare Jacq leaves (ethanolic extract) on experimentally induced gastric ulceration in rats.World J. Pharm. Pharm. Sci.20165145159
     [Google Scholar]
  28. TamboliF. MoreH. Evaluation of antiulcer and antioxidant activity of Barleria gibsoni Dalz. leaves.Pharmacognosy Res.20168422623010.4103/0974‑8490.188879 27695259
     [Google Scholar]
  29. SahooS.K. SahooH.B. PriyadarshiniD. SoundaryaG. KumarC.K. RaniK.U. Antiulcer activity of ethanolic extract of Salvadora indica (W.) leaves on Albino rats.J. Clin. Diagn. Res.2016109FF07FF1010.7860/JCDR/2016/20384.8470 27790462
     [Google Scholar]
  30. MartinsL.C. CorveloT.C. OtiH.T. BarileK.A. Helicobacter pylori empacientes com úlcera gástrica na região Norte do Brasil.Med. Trop.200235307310
     [Google Scholar]
  31. SonnenbergA. EverhartJ.E. The prevalence of self-reported peptic ulcer in the United States.Am. J. Public Health199686220020510.2105/AJPH.86.2.200 8633736
     [Google Scholar]
  32. Available from. http://www.cme.med.umich.edu/pdf/guideline/PUD05.pdf
  33. SomervellT.H. OrrI.M. Some contributions to the causation, pathology, and treatment of duodenal ulcer and its complications.Br. J. Surg.2005249422724510.1002/bjs.1800249406
     [Google Scholar]
  34. DograJ.R. Studies on peptic ulcer in South India.Indian J. Med. Res.194028145161
     [Google Scholar]
  35. HadleyG.G. Studies of peptic ulcer as found in South India.ICMR1959393133
     [Google Scholar]
  36. MalhotraS.L. MajumdarC.T. BardoloiP.C. Peptic ulcer in Assam.Gut19645435535810.1136/gut.5.4.355 14209920
     [Google Scholar]
  37. RaghavachariC. Note on peptic ulcer.Ind. Coun. Med. Res.1959394851
     [Google Scholar]
  38. GreggL.A. Note on peptic ulcer.Indian Council Med. Res. Reports1959396567
     [Google Scholar]
  39. GoodmanL. GilmanA. BruntonL. LazoJ. ParkerK. Goodman & Gilman’s the pharmacological basis of therapeutics.New YorkMcGraw-Hill2006
     [Google Scholar]
  40. GrayS.J. Chronicstress and peptic ulcer. I. Effect of corticotropin (ACTH) andcortisone on gastric secretion.JAMA19511471614291537
     [Google Scholar]
  41. WillemsJ.L. Neuronal dopamine receptors on autonomic gan-glia and sympathetic nerves and dopamine receptors in thegastrointestinal system.Pharmacol. Rev.1985372165216 2996038
     [Google Scholar]
  42. RasheedN. AlghashamA. Central dopaminergic system and its implications in stress-mediated neurological disorders and gastric ulcers: Short review.Adv. Pharmacol. Sci.2012201211110.1155/2012/182671 23008702
     [Google Scholar]
  43. ArafaK. Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-kb mediated inflammation and apoptosis in experimental gastric ulcer.Chem. Biol. Interact.201727326627210.1016/j.cbi.2017.06.022 28648817
     [Google Scholar]
  44. BhalaN. EmbersonJ. MerhiA. AbramsonS. ArberN. BaronJ.A. BombardierC. CannonC. FarkouhM.E. FitzGeraldG.A. GossP. HallsH. HawkE. HawkeyC. HennekensC. HochbergM. HollandL.E. KearneyP.M. LaineL. LanasA. LanceP. LaupacisA. OatesJ. PatronoC. SchnitzerT.J. SolomonS. TugwellP. WilsonK. WittesJ. BaigentC. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: Meta-analyses of individual participant data from randomised trials.Lancet2013382989476977910.1016/S0140‑6736(13)60900‑9 23726390
     [Google Scholar]
  45. BjarnasonI. ScarpignatoC. TakeuchiK. RainsfordK.D. Determinants of the short-term gastric damage caused by NSAIDs in man.Aliment. Pharmacol. Ther.20072619510610.1111/j.1365‑2036.2007.03348.x 17555426
     [Google Scholar]
  46. NarayananM. ReddyK.M. MarsicanoE. Peptic ulcer disease and Helicobacter pylori infection.Mo. Med.20181153219224 30228726
     [Google Scholar]
  47. Helicobacter pylori, T cells and cytokines: The "dangerous liaisons".Available from: https://www.researchgate.net/figure/T-cell-mediated-immunopathology-in-peptic-ulcer-gastric-MALT-B-cell-lymphoma-and_fig1_7872404(accessed 16 Nov, 2022)
  48. DeyI. LejeuneM. ChadeeK. Prostaglandin E 2 receptor distribution and function in the gastrointestinal tract.Br. J. Pharmacol.2006149661162310.1038/sj.bjp.0706923 17016496
     [Google Scholar]
  49. MUSUMBA, C.; PRITCHARD, D.M. Review article: Cellular and molecular mechanisms of NSAID-induced peptic ulcers.AP T.200930517531
     [Google Scholar]
  50. Nonsteroidal Anti-inflammatory Drug and Aspirin-induced Peptic Ulcer Disease.Available from: https://www.researchgate.net/figure/Two-related-isoforms-of-the-COX-and-LOX-enzyme-pathway-and-the-role-of-non-steroidal_fig1_304357264(accessed 16 Nov, 2022)
  51. SenayE.C. LevineR.J. Synergism between cold and restraint for rapid production of stress ulcers in rats.Exp. Biol. Med.196712441221122310.3181/00379727‑124‑31970 6024838
     [Google Scholar]
  52. LevineR.J. A method for rapid production of stress ulcers in rats.Peptic Ulcer. PfeifferC.J. Copenhagen, DenmarkMunksgaard19719297
     [Google Scholar]
  53. VincentG. GlavinG. RutkowskiJ. ParéW. Body orientation, food deprivation and potentiation of restraint induced gastric lesions.Gastroenterol. Clin. Biol.197716-7539543 892326
     [Google Scholar]
  54. DavenportH.W. Salicylate damage to the gastric mucosal barrier.N. Engl. J. Med.1967276231307131210.1056/NEJM196706082762308 6024894
     [Google Scholar]
  55. DjahanguiriB. The production of acute gastric ulceration by indomethacin in the rat.Scand. J. Gastroenterol.196943265267 5346672
     [Google Scholar]
  56. BhargavaK.P. GuptaM.B. TangriK.K. Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone.Eur. J. Pharmacol.197322219119510.1016/0014‑2999(73)90012‑5 4514976
     [Google Scholar]
  57. ChoC.H. OgleC.W. The pharmacological differences and similarities between stress- and ethanol-induced gastric mucosal damage.Life Sci.199251241833184210.1016/0024‑3205(92)90034‑M 1447949
     [Google Scholar]
  58. OatesP.J. HakkinenJ.P. Studies on the mechanism of ethanol-induced gastric damage in rats.Gastroenterology1988941102110.1016/0016‑5085(88)90604‑X 3335281
     [Google Scholar]
  59. TakagiK. A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing Japanese.J. Clin. Pharmacol.1970193418421
     [Google Scholar]
  60. OkabeS. Chronicity of acetic acid in the rats’ stomach.J. Dig. Dis.19721461962910.1007/BF02231748
     [Google Scholar]
  61. OkabeS. AmagaseK. An overview of acetic acid ulcer models--the history and state of the art of peptic ulcer research.Biol. Pharm. Bull.20052881321134110.1248/bpb.28.1321 16079471
     [Google Scholar]
  62. HayL.J. Experimental production of gastric and duodenal ulcers in laboratory animals by intramuscular injection of histamine in beeswax.Surg. Gynecol. Obstet.19427470182
     [Google Scholar]
  63. KagoshimaM. SuguroN. Gastric movements and reserpine-induced ulcer in rats.Nippon Yakurigaku Zasshi198280323123810.1254/fpj.80.231 7152393
     [Google Scholar]
  64. HashizumeT. HirokawaK. AibaraS. OgawaH. KasaharaA. Pharmacological and histological studies of gastric mucosal lesion induced by serotonin in rats.Arch. Int. Pharmacodyn. Ther.1978236196108 747467
     [Google Scholar]
  65. LePardK.J. StephensR.L. Jr Serotonin inhibits gastric acid secretion through a 5-hydroxytryptamine1-like receptor in the rat.J. Pharmacol. Exp. Ther.1994270311391144 7932163
     [Google Scholar]
  66. ShayH. A simple method for the uniform production of gastric ulceration in the rat.Gastroenterology194554361
     [Google Scholar]
  67. OkaS. Role of reactive oxygen species in diethyldilthiocarbamate induced gastric ulcer in the rat.Experentia199046281283
     [Google Scholar]
  68. ShahD.I. SantaniD.D. GoswamiS.S. A novel use of methylene blue as a pharmacological tool.J. Pharmacol. Toxicol. Methods200654327327710.1016/j.vascn.2005.12.003 16488629
     [Google Scholar]
  69. WadaK. KamisakiY. KitanoM. KishimotoY. NakamotoK. ItohT. A new gastric ulcer model induced by ischemia-reperfusion in the rat: Role of leukocytes on ulceration in rat stomach.Life Sci.19965919PL295PL30110.1016/0024‑3205(96)00500‑0 8913334
     [Google Scholar]
  70. SzaboS. Animal model of human disease. Duodenal ulcer disease: Cysteamine-induced acute and chronic duodenal ulcer in the rat.Am. J. Clin. Pathol.1978731273276
     [Google Scholar]
  71. TakeuchiK. FurukawaO. TanakaH. OkabeS. A new model of duodenal ulcers induced in rats by indomethacin plus histamine.Gastroenterology198690363664510.1016/0016‑5085(86)91118‑2 3943695
     [Google Scholar]
  72. NaitoY. YoshikawaT. YonetaT. YagiN. MatsuyamaK. AraiM. TanigawaT. KondoM. A new gastric ulcer model in rats produced by ferrous iron and ascorbic acid injection.Digestion199556647247810.1159/000201278 8536816
     [Google Scholar]
  73. KonturekP. BrzozowskiT. KaniaJ. KonturekS.J. KwiecienS. PajdoR. HahnE.G. Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat.Eur. J. Pharmacol.2003472321322010.1016/S0014‑2999(03)01932‑0 12871756
     [Google Scholar]
  74. AdinorteyM.B. In vivo models used for evaluation of potential anti-gastroduodenal ulcer agents.Ulcers2013201312
     [Google Scholar]
  75. NyarkoA.K. A Manual of Harmonised Procedures for Assessing the Safety, Efficacy and Quality of Plant Medicines in Ghana.Accra, GhanaYemens Press2005
     [Google Scholar]
  76. ShayneP. Gastritis and peptic ulcer disease: Treatment & medication.Available from http://emedicine.medscape.com/article/776460-treatment(Accessed 18 Nov, 2022)
  77. KitagawaH. FujiwaraM. OsumiY. Effects of water-immersion stress on gastric secretion and mucosal blood flow in rats.Gastroenterology197977229830210.1016/0016‑5085(79)90281‑6 447044
     [Google Scholar]
  78. GuthP.H. Gastric blood flow in restraint stress.Am. J. Dig. Dis.197217980781310.1007/BF02231152 5056862
     [Google Scholar]
  79. RainsfordK.D. The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice.Agents Actions1987213-431631910.1007/BF01966502 3687587
     [Google Scholar]
  80. SinghS. Evaluation of gastric anti-ulcer activity of fixed oil of Ocimum basilicum Linn. and its possible mechanism of action.Indian J. Exp. Biol.1999373253257 10641155
     [Google Scholar]
  81. KumarV. AbbasA.K. FaustoN. Pathologic basis of disease.Robbins and Cotran.7th edNew Delhi, IndiaSaunders2003787802
     [Google Scholar]
  82. MalfertheinerP. MégraudF. O’MorainC. HunginA.P.S. JonesR. AxonA. GrahamD.Y. TytgatG. Current concepts in the management of Helicobacter pylori infection-The Maastricht 2-2000 Consensus Report.Aliment. Pharmacol. Ther.200216216718010.1046/j.1365‑2036.2002.01169.x 11860399
     [Google Scholar]
  83. QasimA. O’MorainC.A. Treatment of Helicobacter pylori infection and factors influencing eradication.Aliment. Pharmacol. Ther.200216Suppl. 1243010.1046/j.1365‑2036.2002.0160s1024.x 11849124
     [Google Scholar]
  84. SeymourM. AndersenD. Surgery for Peptic Ulcer Disease and postgastrectomy syndromes.Textbook of Gastroenterology.4th edPhiladelphiaLippincott Williams and Wilkins200314411454
     [Google Scholar]
  85. LaheijR.J. RossumL.G.M.V. JansenJ.B. StraatmanH. VerbeekA.L. Evaluation of treatment regimens to cure Helicobacter pylori infection-a meta-analysis.Aliment. Pharmacol. Ther.199913785786410.1046/j.1365‑2036.1999.00542.x 10383518
     [Google Scholar]
  86. UmaruI.J. Review: Peptic ulcer disease and its implications.Res. Gastric Manag. Hepatol.2022111419
     [Google Scholar]
  87. OrtaçD. CemekM. KaracaT. BüyükokuroğluM.E. ÖzdemirZ.Ö. KocamanA.T. GöneşS. In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions.Pharm. Biol.201856116517510.1080/13880209.2018.1442481 29513129
     [Google Scholar]
  88. PatankarR. DevaleT. PophaleR. GawandeV. RaghavN. Antiulcer activity of Acacia catechu willd in rats.Int. J. Res. Ayurveda Pharm.20112515851587
     [Google Scholar]
  89. SowndhararajanK. KangS.C. Protective effect of ethyl acetate fraction of Acacia ferruginea DC. against ethanol-induced gastric ulcer in rats.J. Ethnopharmacol.2013148117518110.1016/j.jep.2013.04.007 23608239
     [Google Scholar]
  90. BansalV.K. GoelR.K. Gastroprotective effect of Acacia nilotica young seedless pod extract: Role of polyphenolic constituents.Asian Pac. J. Trop. Med.20125752352810.1016/S1995‑7645(12)60092‑3 22647813
     [Google Scholar]
  91. MarhuendaE. Alarcón de la LastraC. MartínM.J. Antisecretory and gastroprotective effects of aescine in rats.Gen. Pharmacol.19942561213121910.1016/0306‑3623(94)90140‑6 7875547
     [Google Scholar]
  92. Kouitcheu MabekuL.B. Nanfack NanaB. Eyoum BilleB. Tchuenteu TchuenguemR. NguepiE. Anti-Helicobacter pylori and antiulcerogenic activity of aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats.Pharm. Biol.201755192993610.1080/13880209.2017.1285326 28164737
     [Google Scholar]
  93. MitraP.K. Comparative evaluation of anti gastric ulcer activity of root, stem and leaves of Amaranthus spinosus Linn. in rats.Int. J. Herb. Med.201312229
     [Google Scholar]
  94. DevarajV.C. KrishnaB.G. Gastric antisecretory and cytoprotective effects of leaf extracts of Amaranthus tricolor Linn. in rats.J. Chin. Integr. Med.2011991031103810.3736/jcim20110915 21906529
     [Google Scholar]
  95. Hiruma-LimaC.A. GraciosoJ.S. TomaW. AlmeidaA.B. PaulaA.C. BrasilD.S.B. MullerA.H. Souza BritoA.R.M. Souza BritoA.R.M. Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice.Phytomedicine2001829410010.1078/0944‑7113‑00017 11315762
     [Google Scholar]
  96. PowandaM.C. WhitehouseM.W. RainsfordK.D. Celery seed and related extracts with antiarthritic, antiulcer, and antimicrobial activities.Prog. Drug Res.20157013315310.1007/978‑3‑0348‑0927‑6_4
     [Google Scholar]
  97. LeeE.B. KimO.J. KangS.S. JeongC. Araloside A, an antiulcer constituent from the root bark of Aralia elata.Biol. Pharm. Bull.200528352352610.1248/bpb.28.523 15744082
     [Google Scholar]
  98. CarlottoJ. da SilvaL.M. DartoraN. Maria-FerreiraD. SabryD.A. FilhoA.P.S. de Paula WernerM.F. SassakiG.L. GorinP.A.J. IacominiM. CiprianiT.R. de SouzaL.M. Identification of a dicaffeoylquinic acid isomer from Arctium lappa with a potent anti-ulcer activity.Talanta2015135505710.1016/j.talanta.2014.11.068 25640125
     [Google Scholar]
  99. GadhiC.A. BenharrefA. JanaM. LozniewskiA. Anti-Helicobacter pylori activity of Aristolochia paucinervis Pomel extracts.J. Ethnopharmacol.2001752-320320510.1016/S0378‑8741(01)00184‑2 11297852
     [Google Scholar]
  100. ParkS.W. OhT.Y. KimY.S. SimH. ParkS.J. JangE.J. ParkJ.S. BaikH.W. HahmK.B. Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats.J. Gastroenterol. Hepatol.200823697698410.1111/j.1440‑1746.2008.05333.x 18444990
     [Google Scholar]
  101. AntonisamyP. DuraipandiyanV. AravinthanA. Al-DhabiN.A. IgnacimuthuS. ChoiK.C. KimJ.H. Protective effects of friedelin isolated from Azima tetracantha Lam. against ethanol-induced gastric ulcer in rats and possible underlying mechanisms.Eur. J. Pharmacol.201575016717510.1016/j.ejphar.2015.01.015 25617794
     [Google Scholar]
  102. MassignaniJ.J. LemosM. MaistroE.L. SchaphauserH.P. JorgeR.F. SousaJ.P.B. BastosJ.K. de AndradeS.F. Antiulcerogenic activity of the essential oil of Baccharis dracunculifolia on different experimental models in rats.Phytother. Res.200923101355136010.1002/ptr.2624 19274697
     [Google Scholar]
  103. KumarV. BhatZ.A. KumarD. KhanN.A. ChashooI.A. AraI. Gastroprotective effect of leaf extracts of Basella alba var. alba against experimental gastric ulcers in rats.Rev. Bras. Farmacogn.201222365766210.1590/S0102‑695X2012005000032
     [Google Scholar]
  104. Eyoum BilleB. NguepiE. In vitro and in vivo anti-helicobacter activities of eryngium foetidum (apiaceae), bidens pilosa (asteraceae), and galinsoga ciliata (asteraceae) against helicobacter pylori.BioMed Res. Int.201620162171032
     [Google Scholar]
  105. MoonJ.K. KimJ.R. AhnY.J. ShibamotoT. Analysis and anti-helicobacter activity of sulforaphane and related compounds present in broccoli (Brassica oleracea L.) sprouts.J. Agric. Food Chem.201058116672667710.1021/jf1003573 20459098
     [Google Scholar]
  106. KimA-Y. KiM-R. ParkS-H. AhnY-T. LeeE-M. LeeE-J. ParkS-I. HuhC-S. JeongK-S. Anti-Helicobacter pylori activity of phytochemicals from Brassica rapa L.Biomed. Res.201627411231129
     [Google Scholar]
  107. Kouitcheu MabekuL.B. Eyoum BilleB. TchouangueuT.F. NguepiE. LeundjiH. Treatment of Helicobacter pylori infected mice with Bryophyllum pinnatum, a medicinal plant with antioxidant and antimicrobial properties, reduces bacterial load.Pharm. Biol.201755160361010.1080/13880209.2016.1266668 27937097
     [Google Scholar]
  108. PatelK PatelB PatelA ShahS Pharmacological evaluation of anti-ulcer activity of caesalpinia crista in rats.IJPSN2018104
     [Google Scholar]
  109. LemosL.M.S. MartinsT.B. TanajuraG.H. GazoniV.F. BonaldoJ. StradaC.L. SilvaM.G. Dall’OglioE.L. de Sousa JúniorP.T. MartinsD.T.O. Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb.J. Ethnopharmacol.2012141143243910.1016/j.jep.2012.03.006 22425905
     [Google Scholar]
  110. SiniK.R. SinhaB.N. RajasekaranA. Protective effects of Capparis zeylanica Linn. Leaf extract on gastric lesions in experimental animals.Avicenna J. Med. Biotechnol.2011313135 23407576
     [Google Scholar]
  111. LiN.S. LuoX.J. DaiZ. LiuB. ZhangY.S. YangZ.C. PengJ. Beneficial effects of capsiate on ethanol-induced mucosal injury in rats are related to stimulation of calcitonin gene-related Peptide release.Planta Med.2012781243010.1055/s‑0031‑1280217 21928164
     [Google Scholar]
  112. KumarK. MruthunjayaK. KumarS. MythreyiR. Anti ulcer activity of ethanol extract of the stem bark of Careya arborea Roxb.Int. Curr. Pharm. J.201323788210.3329/icpj.v2i3.13633
     [Google Scholar]
  113. NarteyE.T. OfosuheneM. AgbaleC.M. Anti-ulcerogenic activity of the root bark extract of the African laburnum “Cassia sieberiana” and its effect on the anti-oxidant defence system in rats.BMC Complement. Altern. Med.201212124710.1186/1472‑6882‑12‑247 23228052
     [Google Scholar]
  114. OdeO. AsuzuO. Investigation of cassia singueana leaf extract for antiulcer effects using ethanol-induced gastric ulcer model in rats.IJPAES2011117
     [Google Scholar]
  115. MartinsJ.L.R. RodriguesO.R.L. da SilvaD.M. GaldinoP.M. de PaulaJ.R. RomãoW. da CostaH.B. VazB.G. GhediniP.C. CostaE.A. Mechanisms involved in the gastroprotective activity of Celtis iguanaea (Jacq.) Sargent on gastric lesions in mice.J. Ethnopharmacol.201415531616162410.1016/j.jep.2014.08.006 25153020
     [Google Scholar]
  116. VianaA.F.S.C. FernandesH.B. SilvaF.V. OliveiraI.S. FreitasF.F.B.P. MachadoF.D.F. CostaC.L.S. ArcanjoD.D.R. ChavesM.H. OliveiraF.A. OliveiraR.C.M. Gastroprotective activity of cenostigma macrophyllum Tul. var. acuminata teles freire leaves on experimental ulcer models.J. Ethnopharmacol.2013150131632310.1016/j.jep.2013.08.047 24035848
     [Google Scholar]
  117. KhanaviM. AhmadiR. RajabiA. Jabbari ArfaeeS. HassanzadehG. KhademiR. HadjiakhoondiA. BeyerC. SharifzadehM. Pharmacological and histological effects of Centaurea bruguierana ssp. belangerana on indomethacin-induced peptic ulcer in rats.J. Nat. Med.201266234334910.1007/s11418‑011‑0598‑7 21993908
     [Google Scholar]
  118. BakhtaouiF-Z. LakmichiH. ChaitA. GadhiC.A. In vivo gastro-protective effects of five moroccan medicinal plants against gastric ulcernt.J. Med. Res. Rev.2014212621276
     [Google Scholar]
  119. YeH. LiuY. LiN. YuJ. ChengH. LiJ. ZhangX-Z. Anti- Helicobacter pylori activities of Chenopodium ambrosioides L. in vitro and in vivo.World J. Gastroenterol.201521144178418310.3748/wjg.v21.i14.4178 25892867
     [Google Scholar]
  120. SilvaA.A.R. BezerraM.M. ChavesH.V. PereiraK.M.A. AguiarJ.A. PintoV.P.T. AbbetC. Simões-PiresC.A. FrancoE.S. HenriquesA.T. HostettmannK. MaiaM.B.S. Protective effect of Chresta martii extract against indomethacin-induced gastric lesions in mice.J. Nat. Med.201367114315110.1007/s11418‑012‑0663‑x 22450730
     [Google Scholar]
  121. EnechiO.O.C. IgbonekwuC.N. UgwuO.P.C. Effects of ethanol extract of Cissus quadrangularis on induced gastric ulcer in rats.Afr. J. Biotechnol.201312436197620210.5897/AJB2013.12898
     [Google Scholar]
  122. ReddyV.P. SudheshnaG. AfsarS. SaranS. KumarS.N. RamC.R. ReddyK.R. Evaluation of anti-ulcer activity of Citrullus colocynthis fruit against pylorus ligation induced ulcers in male wistar rats.Int. J. Pharm. Pharm. Sci.20124446451
     [Google Scholar]
  123. SharmaS. PaliwalS. DwivediJ. JainS. DaveV. Gastroprotective activity of reconstituted red fruit pulp concentrate of Citrullus lanatus in rats.Anc. Sci. Life201434210310810.4103/0257‑7941.153472 25861146
     [Google Scholar]
  124. ManoharanP. JohnS. Anti-ulcer effect of Coccinia grandis (Linn.) on pylorus ligated (albino) rats.Int. J. Pharm.20102
     [Google Scholar]
  125. PoovendranP. KalaigandhiV. PoongunranE. Antimicrobial activity of the leaves of cocculus hirsutus against gastric ulcer producing helicobacter pylori.J. Pharm. Res.2011442944295
     [Google Scholar]
  126. NunesP.H. CavalcantiP.M. GalvãoS.M. MartinsM.C. Antiulcerogenic activity of combretum leprosum.Pharmazie20096415862 19216233
     [Google Scholar]
  127. AdzuB. BalogunS.O. PavanE. AscêncioS.D. SoaresI.M. AguiarR.W.S. RibeiroR.V. BeserraÂ.M.S.S. de OliveiraR.G. da SilvaL.I. DamazoA.S. MartinsD.T.O. Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms.J. Ethnopharmacol.201517537838910.1016/j.jep.2015.09.027 26408044
     [Google Scholar]
  128. Al BatranR. Al-BayatyF. Ameen AbdullaM. Jamil Al-ObaidiM.M. HajrezaeiM. HassandarvishP. FouadM. GolbabapourS. TalaeeS. Gastroprotective effects ofC orchorus olitorius leaf extract against ethanol‐induced gastric mucosal hemorrhagic lesions in rats.J. Gastroenterol. Hepatol.20132881321132910.1111/jgh.12229 23611708
     [Google Scholar]
  129. InasZ. HalaA.K. GehanH.H. Gastroprotective effect of Cordia myxa L. fruit extract against indomethacin-induced gastric ulceration in rats.Life Sci. J.20118433445
     [Google Scholar]
  130. RoldãoE.F. WitaicenisA. SeitoL.N. Hiruma-LimaC.A. Di StasiL.C. Evaluation of the antiulcerogenic and analgesic activities of Cordia verbenacea DC. (Boraginaceae).J. Ethnopharmacol.20081191949810.1016/j.jep.2008.06.001 18588967
     [Google Scholar]
  131. JahanN. NikhatS. AhmadG. Efficacy of Tukhm Kishneez (Coriandrum sativum Linn.) in stress induced gastric ulcer.Unani Res.201111722
     [Google Scholar]
  132. Coelho-de-SouzaA.N. LahlouS. BarretoJ.E.F. YumM.E.M. OliveiraA.C. OliveiraH.D. CeledônioN.R. FeitosaR.G.F. DuarteG.P. SantosC.F. de AlbuquerqueA.A.C. Leal-CardosoJ.H. Essential oil of croton zehntneri and its major constituent anethole display gastroprotective effect by increasing the surface mucous layer.Fundam. Clin. Pharmacol.201327328829810.1111/j.1472‑8206.2011.01021.x 22211386
     [Google Scholar]
  133. Palacios-EspinosaJ.F. Arroyo-GarcíaO. García-ValenciaG. LinaresE. ByeR. RomeroI. Evidence of the anti-helicobacter pylori, gastroprotective and anti-inflammatory activities of Cuphea aequipetala infusion.J. Ethnopharmacol.2014151299099810.1016/j.jep.2013.12.012 24342782
     [Google Scholar]
  134. CzekajR. MajkaJ. MagierowskaK. SliwowskiZ. MagierowskiM. PajdoR. Ptak-BelowskaA. SurmiakM. KwiecienS. BrzozowskiT. Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions.J. Gastroenterol.201853561863010.1007/s00535‑017‑1385‑3 28856444
     [Google Scholar]
  135. RahimN.A. HassandarvishP. GolbabapourS. IsmailS. TayyabS. AbdullaM.A. Gastroprotective effect of ethanolic extract of curcuma xanthorrhiza leaf against ethanol-induced gastric mucosal lesions in sprague-dawley rats.Biomed Res. Int.20142014416409
     [Google Scholar]
  136. SagradasJ. CostaG. FigueirinhaA. Castel-BrancoM.M. Silvério CabritaA.M. FigueiredoI.V. BatistaM.T. Gastroprotective effect of cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats.J. Ethnopharmacol.201517313413810.1016/j.jep.2015.07.001 26160747
     [Google Scholar]
  137. PatilM. JalalpureS. PrakashN. KokateC. Antiulcer properties of alcoholic extract of cynodon dactylon in rats.Acta Hortic.200311511810.17660/ActaHortic.2005.680.16
     [Google Scholar]
  138. JamalA. JavedK. AslamM. JafriM.A. Gastroprotective effect of cardamom, elettaria cardamomum Maton. fruits in rats.J. Ethnopharmacol.2006103214915310.1016/j.jep.2005.07.016 16298093
     [Google Scholar]
  139. FranklinA. RaoU. VijayakumarR. SrikumarR. In-vitro anti- helicobacter pylori activity of emblica officinalis.Int. J. Microbiol. Res.20123216220
     [Google Scholar]
  140. SiminialayiI. AgbajeE. Gastroprotective effects of the ethanolic extract of Enantia chlorantha in rats.West Afr. J. Pharmacol. Drug Res.2004203538
     [Google Scholar]
  141. SachinS.S. ArchanaR.J. Antiulcer activity of methanol extract of Erythrina indica Lam. leaves in experimental animals.Pharmacognosy Res.20091396
     [Google Scholar]
  142. AdeniyiC.B.A. LawalT.O. MahadyG.B. In vitro susceptibility of helicobacter pylori to extracts of eucalyptus camaldulensis and eucalyptus torelliana.Pharm. Biol.20094719910210.1080/13880200802448708 20396588
     [Google Scholar]
  143. ThirunavukkarasuP. RamkumarL. RamanathanT. Anti-ulcer activity of excoecaria agallocha bark on nsaid-induced gastric ulcer in albino rats.Glob. J. Pharmacol.20093123126
     [Google Scholar]
  144. ReyesM. Schmeda-HirschmannG. RazmilicI. TheodulozC. YáñezT. RodríguezJ.A. Gastroprotective activity of sesquiterpene derivatives fromFabiana imbricata.Phytother. Res.200519121038104210.1002/ptr.1784 16372369
     [Google Scholar]
  145. KhazaeiM. SalehiH. Protective effect of falcaria vulgaris extract on ethanol induced gastric ulcer in rat.Iran. J. Pharmacol. Ther.2006543
     [Google Scholar]
  146. MuthulakshmiA. MargretR.J. MohanV. Antiulcer effect of feronia elephantum correa leaf and bark extract in indomethacin induced albino rats.J. Appl. Pharm. Sci.20133S71
     [Google Scholar]
  147. AlqasoumiS. Al-DosariM. Al-HowirinyT. Al-YahyaM. Gastric antiulcer activity of a pungent spice Ferula assafoetida in rats.Farmacia201159750759
     [Google Scholar]
  148. NieroR. MolinM.M.D. SilvaS. DamianN.S. MaiaL.O. MonacheF.D. FilhoV.C. de AndradeS.F. Gastroprotective effects of extracts and guttiferone a isolated from garcinia achachairu rusby (Clusiaceae) against experimentally induced gastric lesions in mice.Naunyn Schmiedebergs Arch. Pharmacol.2012385111103110910.1007/s00210‑012‑0788‑1 22926730
     [Google Scholar]
  149. MahendranP. SabithaK. DeviS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action.Indian J. Exp. Biol.20024015862
     [Google Scholar]
  150. OlaleyeS. FarombiE. Attenuation of indomethacin- and HCl/ethanol-induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed.Phytother. Res.20062011420
     [Google Scholar]
  151. ZhangX.Q. GuH.M. LiX.Z. XuZ.N. ChenY.S. LiY. Anti-Helicobacter pylori compounds from the ethanol extracts of Geranium wilfordii.J. Ethnopharmacol.2013147120420710.1016/j.jep.2013.02.032 23500884
     [Google Scholar]
  152. ChenS.H. LiangY-C. ChaoJ.C. TsaiL-H. ChangC-C. WangC-C. PanS. Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats.World J. Gastroenterol.200511243746375010.3748/wjg.v11.i24.3746 15968732
     [Google Scholar]
  153. Jalilzadeh-AminG. NajarnezhadV. AnassoriE. MostafaviM. KeshipourH. Antiulcer properties of Glycyrrhiza glabra L. extract on experimental models of gastric ulcer in mice.Iran. J. Pharm. Res.201514411631170 26664383
     [Google Scholar]
  154. MahmoodA. MariodA.A. Al-BayatyF. Abdel-WahabS.I. Anti-ulcerogenic activity of Gynura procumbens leaf extract against experimentally-induced gastric lesions in rats.J. Med. Plants Res.20104685691
     [Google Scholar]
  155. IbaraJ-R. Elion ItouR.D.G. OuambaJ.M. DiatewaM. GbeassorM. AbenaA.A. Preliminary evaluation of antiulcerogenic activity of Ceiba pentandra Gaertn. and Helicrysum mechowianum Klatt in rats.J. Med. Sci.20077348548810.3923/jms.2007.485.488
     [Google Scholar]
  156. BalogunS.O. DamazoA.S. de Oliveira MartinsD.T. Helicteres sacarolha A. St.- Hil. et al.: Gastroprotective and possible mechanism of actions in experimental animals.J. Ethnopharmacol.201516617618410.1016/j.jep.2015.03.021 25792014
     [Google Scholar]
  157. TuranM.I. BilenH. DemiryilmazI. OzgerisF.B. BaykalH. TurkogluM. SuleymanH. Effects of hypericum perforatum and hippophae rhamnoides extracts on indomethacin-induced gastric oxidative stress in rats.Biomed. Res.201324
     [Google Scholar]
  158. CaldasG.F.R. do Amaral CostaI.M. da SilvaJ.B.R. da NóbregaR.F. RodriguesF.F.G. da CostaJ.G.M. WanderleyA.G. Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae).J. Ethnopharmacol.2011137188689210.1016/j.jep.2011.07.005 21774910
     [Google Scholar]
  159. UmaraniN. IlangoK. ValentinaP. SunithaG. Antiulcer activity of various extracts of leaves of Indigofera tinctoria.Int. J. Chem. Sci.20086281284
     [Google Scholar]
  160. PandaV. SonkambleM. Anti-ulcer activity of ipomoea batatas tubers (sweet potato).Funct. Food Health Dis.201223486110.31989/ffhd.v2i3.99
     [Google Scholar]
  161. GoliV. MacharlaS.P. BhaskerK.V. GowrishankarN. Antiulcer activity of leaf extract of Lawsonia inermis in albino rats.Res. J. Pharm. Technol.2011414361438
     [Google Scholar]
  162. GuptaJ.K. UpmanyuN. PatnaikA. MazumderP.M. Evaluation of antiulcer activity of leucas lavandulifolia on mucosal lesion in rat.Asian J. Pharm. Clin. Res.20103110120
     [Google Scholar]
  163. GarroM.F. Salinas IbáñezA.G. VegaA.E. Arismendi SosaA.C. PelzerL. SaadJ.R. MariaA.O. Gastroprotective effects and antimicrobial activity of Lithraea molleoides and isolated compounds against Helicobacter pylori.J. Ethnopharmacol.201517646947410.1016/j.jep.2015.11.009 26571088
     [Google Scholar]
  164. PimpleB.P. KadamP.V. PatilM.J. Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: Role of gastric mucosal glycoproteins and antioxidants.Asian Pac. J. Trop. Med.20125861061510.1016/S1995‑7645(12)60126‑6 22840448
     [Google Scholar]
  165. SidahmedH.M.A. AzizanA.H.S. MohanS. AbdullaM.A. AbdelwahabS.I. TahaM.M.E. HadiA.H.A. KetulyK.A. HashimN.M. LokeM.F. VadiveluJ. Gastroprotective effect of desmosdumotin C isolated from Mitrella kentii against ethanol-induced gastric mucosal hemorrhage in rats: Possible involvement of glutathione, heat-shock protein-70, sulfhydryl compounds, nitric oxide, and anti-Helicobacter pylori activity.BMC Complement. Altern. Med.201313118310.1186/1472‑6882‑13‑183 23866830
     [Google Scholar]
  166. AlamS. AsadM. AsdaqS.M.B. PrasadV.S. Antiulcer activity of methanolic extract of Momordica charantia L. in rats.J. Ethnopharmacol.2009123346446910.1016/j.jep.2009.03.024 19501279
     [Google Scholar]
  167. DhasanP.B. JegadeesanM. KavimaniS. Antiulcer activity of aqueous extract of fruits of momordica cymbalaria hook f. in wistar rats.Pharmacognosy Res.201021586110.4103/0974‑8490.60575 21808541
     [Google Scholar]
  168. VijayakumarM. OjhaS.K. RawatA.K.S. EswaranM.B. RaoC.H.V. Antiulcer activity of hydroalchol extract of Momordica dioica roxb. fruit.Indian J. Pharm. Sci.201173557257710.4103/0250‑474X.99018 22923872
     [Google Scholar]
  169. IbrahimI.A.A. AbdullaM.A. HajrezaieM. BaderA. ShahzadN. Al-GhamdiS.S. GushashA.S. HasanpourghadiM. The gastroprotective effects of hydroalcoholic extract of monolluma quadrangula against ethanol-induced gastric mucosal injuries in sprague dawley rats.Drug Des. Devel. Ther.2015109310510.2147/DDDT.S91247 26766904
     [Google Scholar]
  170. GomathyG. VenkatesanD. PalaniS. Gastroprotective potentials of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats.Nat. Prod. Res.201529222107211110.1080/14786419.2014.986726 25471339
     [Google Scholar]
  171. ZakariaZ.A. BalanT. SuppaiahV. AhmadS. JamaludinF. Mechanism(s) of action involved in the gastroprotective activity of Muntingia calabura.J. Ethnopharmacol.201415131184119310.1016/j.jep.2013.12.045 24380736
     [Google Scholar]
  172. PatidarD.K. Anti-ulcer activity of aqueous extract of Murraya koenigii in albino rats.Int. J. Pharma Bio Sci.20112524529
     [Google Scholar]
  173. SumbulS. AsifM. SaudI. AkhtarM. AkhtarM. Evaluation of myrtus communis linn. berries (common myrtle) in experimental ulcer models in rats.Hum. Exp. Toxicol.2010291193594410.1177/0960327110364154 20197454
     [Google Scholar]
  174. ArslanS.O. GelirE. ArmutcuF. CoskunO. GurelA. SayanH. CelikI.L. The protective effect of thymoquinone on ethanol-induced acute gastric damage in the rat.Nutr. Res.200525767368010.1016/j.nutres.2005.06.004
     [Google Scholar]
  175. KumadohD. ArcherM.A. YeboahG.N. KyeneM.O. Boakye-YiadomM. Adi-DakoO. Osei-AsareC. AdaseE. AppiahA.A. MintahS.O. A review on anti-peptic ulcer activities of medicinal plants used in the formulation of enterica, dyspepsia and NPK 500 capsules.Heliyon2021712e0846510.1016/j.heliyon.2021.e08465 34917789
     [Google Scholar]
  176. AmadiE NjokuO AnyanwuJ.
  177. Abd El-GhffarE.A. Al-SayedE. ShehataS.M. EldahshanO.A. EfferthT. The protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior.Food Funct.2018984457446810.1039/C8FO00538A 30073231
     [Google Scholar]
  178. BurciL.M. PereiraI.T. da SilvaL.M. RodriguesR.V. FacundoV.A. MilitãoJ.S.L.T. SantosA.R.S. MarquesM.C.A. BaggioC.H. WernerM.F.P. Antiulcer and gastric antisecretory effects of dichloromethane fraction and piplartine obtained from fruits of Piper tuberculatum Jacq. in rats.J. Ethnopharmacol.2013148116517410.1016/j.jep.2013.04.006 23588092
     [Google Scholar]
  179. da SilvaJuniorI.F. BalogunS.O. de OliveiraR.G. DamazoA.S. MartinsD.T.O. Piper umbellatum L.: A medicinal plant with gastric-ulcer protective and ulcer healing effects in experimental rodent models.J. Ethnopharmacol.201619212313110.1016/j.jep.2016.07.011 27396348
     [Google Scholar]
  180. MadhulathaC. SharaishP. KalyaniG. SushmaG. SubramanianN.S. DeviB.A. Anti-ulcer activity of Pisonia aculeata on Pylorus ligation induced gastric ulcer in rats.Int. J. Pharm. Life Sci.20134314
     [Google Scholar]
  181. SabiuS. GarubaT. SunmonuT. AjaniE. SulymanA. NurainI. BalogunA. Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin a nd Ficus exasperata.Toxicol. Rep.2015226126710.1016/j.toxrep.2015.01.002 28962358
     [Google Scholar]
  182. SanmugapriyaE. VenkataramanS. Antiulcerogenic potential of strychnos potatorum Linn seeds on Aspirin plus pyloric ligation-induced ulcers in experimental rats.Phytomedicine200714536036510.1016/j.phymed.2006.12.025 17317130
     [Google Scholar]
  183. SantinJ.R. LemosM. Klein-JúniorL.C. MachadoI.D. CostaP. de OliveiraA.P. TiliaC. de SouzaJ.P. de SousaJ.P.B. BastosJ.K. de AndradeS.F. Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models.Naunyn Schmiedebergs Arch. Pharmacol.2011383214915810.1007/s00210‑010‑0582‑x 21140134
     [Google Scholar]
  184. BhargavaS. BhargavaP. JainU. Evaluation of ulcer-protective and antimicrobial activity of Syzygium cumini (linn.) Skeels leaves.Pharmacologyonline20093266274
     [Google Scholar]
  185. AsnaashariS. DastmalchiS. JavadzadehY. Gastroprotective effects of herbal medicines (roots).Int. J. Food Prop.201821190292010.1080/10942912.2018.1473876
     [Google Scholar]
  186. MayankK. MradulG. ChandanaV.R. VrishD.A. SachdevY. Anti-ulcerogenic potential of ficus bengalensis leaf, biochemical parameter & histopathological study.J. Appl. Pharm. Sci.201101026568
     [Google Scholar]
  187. SharmaA.K. ChaudharyR.K. SinghS. VedA. ShuklaK.S. SinghA. SinghM.P. KulshreshthaM. HPTLC studies, in silico docking studies, and pharmacological evaluation of elaeocarpus ganitrus as a gastroprotective agent.Cent. Nerv. Syst. Agents Med. Chem.2023231133110.2174/1871524923666230412080313 37394979
     [Google Scholar]
  188. KulshreshthaM. Kumar ChaudharyR. RoyS. Shanker ShuklaK. SinghA. Pratap SinghM. Pharmacological investigation on unraveling mechanism of action of qusqualis indica leaves for predicted treatment of peptic ulcer disease.Curr. Funct. Foods202312e20032321472810.2174/2666862901666230320103455
     [Google Scholar]
/content/journals/cnt/10.2174/0126659786247721231117110442
Loading
A Comprehensive Review on Peptic Ulcer
Current Nutraceuticals 5, e061223224234 (2024); https://doi.org/10.2174/0126659786247721231117110442
/content/journals/cnt/10.2174/0126659786247721231117110442
/content/journals/cnt/10.2174/0126659786247721231117110442
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): medicinal plants; models; pathways; Peptic ulcer; toxicity; treatment

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test