Development, Characterization and Evaluation of Nanoemulgel Used for the Treatment of Skin Disorders

The outer layer of skin and underlying soft layer of tissues have been infected by several infections locally. Infection on local tissue can be overcome by the administration of various topical formulations such as nanoemulgel, niosomal gel, liposomal gel, etc. For obtaining the significant effect of drug delivery, nanoemulgel exhibits a high intensity of activity locally. Emulsion with uniform and extremely small droplet size in the range of 20-200 nm is referred to as nanoemulsion. The emulsion may be oil-in-water or water-in-oil type. This system can improve the permeation of drug substances through the skin. Nanoemulsion is incorporated into a gel base to form Nanoemulgel and can improve the permeation of drug substances through the skin. Nanoemulgel acts as a promising carrier of an intense amount of permitted drugs to produce their effect topically. Efficient adhesion property and immense solubilising of the drug in oil or water phase lead to a larger concentration gradient towards the skin that further increases the penetration of drug substances through the skin. This study provides useful insights into the utilisation of nanoemulgel to provide a better and effective drug delivery tool for the topical system.