The Effects of Vitamin C on Adriamycin-Induced Hypercholesterolemia in Rat

This study investigated the influence of Vitamin C (Vit C) on Adriamycin-induced hypercholesterolemia and body weight in rats. Sixty-four male Albino Wistar rats were divided into eight groups : Control (CO), Adriamycin (ADR), three groups received different doses of Vit C and three groups received Adriamycin plus different doses of Vitamin C (ADR +Vit C). ADR treated rats showed an insignificant increase in serum cholesterol levels compared with the control group (animals). ADR+Vit C groups showed a significant increase of serum cholesterol level compared to the control group. Meanwhile, body weight in ADR treated rats decreased compared with the control group but this reduction was not significant). Body weight in ADR+Vit C groups demonstrated a significant decrease compared to the control animals. Conclusion: Findings of the current study imply that treatment with different doses of Vitamin C have possibly deleterious effects on Adriamycin-induced hypercholesterolemia as a dose dependent manner and body weight in rat.